The aim of this study was to explore pulp healing and reparative dentinogenesis following pulp-capping by using recombinant human insulin-like growth factor I (rhIGF-I). Exposures were made through the mesial horn in first upper molars two-month-old Wistar rats. covered with one dose sterile 4% methylcellulose gel containing either 400 ng rhIGF-I or saline contralateral controls. exposure site closed Teflon membrane, cavity filled IRM cement. Additional capped Dycal as After 3, 7, 28 days,...

Recent studies have shown that the pulp of human teeth contains a population cells with stem cell properties and it has been suggested these originate from pericytes. Molecules Notch signaling pathway regulate fate specification, while Rgs5 represents an excellent marker for Pathological conditions such as dental trauma carious lesion stimulate to elaborate reparative dentin. Previous genes involved in are activated response injury rodent humans. To demonstrate importance pericytes source...

Notch signaling is an evolutionarily conserved pathway that controls the developmental choices made by individual cells. Cells communicate via receptors and their ligands, which direct decisions on fate of stem cells according to states neighbors. In this study we explored after pulp capping adult first upper rat molars. The wound was capped with calcium hydroxide. situ hybridization revealed increased expression genes day 1, showed a tendency decrease 3. Notch1 in subodontoblast zone close...

A novel fast-setting calcium silicate cement with fluoride (CSC) has been developed for potential application in tooth crowns.This study compared the cytotoxicity of CSC compositions and a variety dental materials.We tested (Protooth), MTA, Biodentine, Ketac Molar, Fuji II LC, Vitrebond, DeTrey Zinc, Dycal, IRM, DMEM (negative control) 1% NaOCl (positive control).After setting cements 24 h, specimens were immersed h to obtain material elutes.The elutes serially diluted serumfree three...

Aim: Calcium silicate cements are widely used in endodontics. Novel fast-setting calcium cement with fluoride (Protooth) has been developed for potential applications teeth crowns including cavity lining and cementation. Objective: To evaluate the surface apatite-forming ability of Protooth compositions as a function content immersion time phosphate-buffered saline (PBS). Material methods: Three were tested: (3.5% 10% radiocontrast), ultrafast 20% high (15% 25% radiocontrast). Powders...

Novel fast-setting calcium silicate cement with fluoride (CSC) has been developed for potential applications in tooth crown. The aim of this study was to test the diametral tensile strength (DTS) different CSC compositions humid condition on day1, 28, and 180. We tested 'bond CSC' 3.5% no radiocontrast, 'CSC' 10% 'ultrafast 20% 'high 15% 25% Biodentine, MTA. filled cements after mixing cylindrical molds. Specimens were stored >95% humidity. DTS measured at each time point. had statistically...

This article reports a mixed methods study that uses machine learning and thematic analysis to investigate student evaluation of multiple-choice questions (MCQ). The focus is on medical dental students' experience self-regulated motivation. We evaluate two systems developed at Aarhus University: "MED MCQ" used by students "MCQ anatomy" students. through surveys in SurveyXact with responses from 126 70 use topic modelling over free text responses. machine-learning model identifies groups who,...

Abstract This study assessed the bond strength of resin‐based restorative materials to fast‐setting calcium silicate cement (Aarhus Uinversity, Denmark) when treated with each two one‐bottle universal adhesive systems. The surface ( N = 256) was a self‐priming and self‐etch phosphate monomer‐containing without etching surface. Specimens then received either resin composite or compomer n 32). measured after 1 day 1500 thermocycles 16). failure type visually inspected....

The purpose of this study was to report on the clinical, radiographic, and histological dental findings resulting treatment load in a five-generation family with amelogenesis imperfecta (AI).Thirteen affected 15 unaffected individuals were examined clinically radiographically. In addition, four exfoliated deciduous teeth by scanning electron microscopy microradiography.The mode inheritance AI autosomal-dominant. At eruption, most tooth enamel yellow, lacking translucency, prone gradual loss...

We established a murine periodontitis model by local injection of lipopolysaccharide Porphyromonas gingivalis (Pg‐ LPS ) into the gingival sulcus mandibular left incisor four times with 48‐h interval. The histological examination periodontal tissues demonstrated that significant loss bone and ligaments was observed in lesion side abundant inflammatory cell infiltration. Two days after last injection, Cy5‐labelled si RNA /chitosan particles were injected intraperitoneally (ip). chitosan/si...

Objective: Novel fast-setting calcium silicate cement with fluoride (Protooth) has been developed for potential applications in tooth crowns. The aim of this study was to evaluate the success rate direct pulp capping primary molars using two-layer mineral trioxide aggregate (MTA) and overlying glass ionomer versus one-layer novel 4 10 minutes setting time. Materials methods: Ninety bilaterally symmetrical same jaw 45 patients aged 5 7 years were included. Exposed pulps following caries...

A novel fast-setting calcium silicate cement containing fluoride (novel-CSC) has been developed for applications in tooth crowns. The aim of this study was to assess the ability novel-CSC close experimental gaps at dentin-cement interface. tested against Vitrebond and GC Fuji II LC. Experimental 50 or 300 μm width were created between materials dentin. Specimens with 300-μm-wide gap immersed phosphate-buffered saline closed area measured during 96 h. All specimens analyzed by scanning...

Background: Therapies for muscular dystrophies remain a major challenge in spite of advanced strategies using either cell or gene therapy. We here propose combined approach and As delivery vehicles with specific homing potential we have chosen mesoangioblasts which are stem cells mesodermal potential. This study specifically tests the maintenance myogenic properties by EGFP-transduced their ability to function as retroviral packaging transient culture. Methods: Mesoangioblasts transduced...

The aim of this study was to evaluate the dentine bond strength a novel fast‐setting calcium silicate cement (Protooth) versus hydroxide‐based (Dycal), (ProRoot MTA), and glass ionomer (Ketac‐Molar). Mid‐root slices 1 mm thickness were obtained from human maxillary incisors. After enlarging lumen canal 1.3 mm, cavities randomly filled with test materials. Samples immersed in physiological‐like solution. push‐out tested on days 1, 28, 180 ( n = 12). Failure types bonding determined using...

The aim of this study was to compare the pull-out bond strength prefabricated titanium posts cemented with novel fast-setting calcium silicate, zinc phosphate, or glass ionomer cements.Sixty extracted human maxillary incisors were selected and received root canal treatment. Post space prepared for ParaPost XP size 5 (diameter=1.25 mm). using silicate cement, phosphate cement (n=20). Specimens stored in phosphate-buffered saline 4 weeks. Subsequently, subjected axial tensile force until...