A5102783511- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopedic Infections and Treatments
- HIV/AIDS Research and Interventions
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hip and Femur Fractures
- Healthcare cost, quality, practices
- Spine and Intervertebral Disc Pathology
- Transplantation: Methods and Outcomes
- Streptococcal Infections and Treatments
- Bone fractures and treatments
- Hepatitis C virus research
- Click Chemistry and Applications
- Orthopedic Surgery and Rehabilitation
- Traumatic Brain Injury Research
- Pressure Ulcer Prevention and Management
- Renal Transplantation Outcomes and Treatments
- Vascular Malformations and Hemangiomas
- Neurogenetic and Muscular Disorders Research
- Lower Extremity Biomechanics and Pathologies
- Vascular anomalies and interventions
Purdue University West Lafayette
2019-2025
Texas Scottish Rite Hospital for Children
2022-2024
The University of Texas Southwestern Medical Center
2023-2024
Children's Hospital of Philadelphia
2024
C. S. Mott Children's Hospital
2024
Drake University
2024
Boston Children's Hospital
2024
Boston University
2024
Scottish Rite Freemasonry
2023
Children's Healthcare of Atlanta
2023
Hearts and lungs from donors with hepatitis C viremia are typically not transplanted. The advent of direct-acting antiviral agents to treat virus (HCV) infection has raised the possibility substantially increasing donor organ pool by enabling transplantation hearts HCV-infected into recipients who do have HCV infection.
Patients with psychiatric illness have been shown to experience higher rates of traumatic injury. Injury patterns, treatment decisions, and outcomes not well characterized in patients after injury, particular those who undergo acute surgical intervention. The purpose this analysis was determine mortality, complications, intervention injury.This is a retrospective study trauma ≥18 years old admitted LAC + USC Medical Center between January 2008 March 2015. diagnoses were identified using...
BACKGROUND A disproportionately high percentage of trauma patients use controlled substances, and they often co-ingest multiple drugs. Previous studies have evaluated the effect individual drugs on clinical outcomes after trauma. However, impact all included in a comprehensive screening panel has not yet been compared single cohort patients. METHODS All who underwent urine drug screens admission to LAC + USC Medical Center (January 2008–June 2015) were identified retrospectively. Univariable...
The rate of venous thromboembolism in children with musculoskeletal infections (MSKIs) is markedly elevated compared hospitalized general. Predictive biomarkers to identify high-risk patients are needed prevent the significant morbidity and rare mortality associated thrombotic complications. We hypothesize that overactivation acute phase response development pathologic thrombi we aim determine whether elevations C-reactive protein (CRP) increased rates thrombosis pediatric MSKI.A...
Abstract We report the synthesis and biological evaluation of phenylcarboxylic acid phenylboronic containing HIV‐1 protease inhibitors their functional effect on enzyme inhibition antiviral activity in MT‐2 cell lines. Inhibitors bearing bis ‐THF ligand as P2 acids carboxamide P2′ ligands, showed very potent inhibitory activity. However, carboxylic poor relative to carboxamide‐derived which good IC 50 value. Boronic derived inhibitor with activity, but it lower than darunavir same assay. a...
Background: Socioeconomic disparities in musculoskeletal care are increasingly recognized, however, no studies to date have investigated the role of insurance carrier on outcomes after posterior spinal fusion (PSF) with segmental instrumentation for adolescent idiopathic scoliosis (AIS). Methods: A US dataset was queried using PearlDiver Mariner software all patients aged 10 18 undergoing PSF a primary diagnosis AIS between 2010 and 2020. Age, sex, geographic region, number levels fused,...
Posterior spinal instrumentation and fusion has become the gold standard for definitive management of children adolescents with deformity. Despite continued innovations designed to improve safety profile this complex surgical undertaking, cord injury resulting loss neurologic function remain a rare but devastating risk. The increasing power combined more aggressive correction strategies puts at particular risk due traction. While surgeon luxury neuromonitoring techniques alert team in...
The design, synthesis, biological evaluation, and X-ray structural studies are reported for a series of highly potent HIV-1 protease inhibitors. inhibitors incorporated stereochemically defined amide-based bicyclic tricyclic ether derivatives as the P2 ligands with (R)-hydroxyethylaminesulfonamide transition-state isosteres. A number showed excellent inhibitory antiviral activity; however, ligand combination is critical potency. Inhibitor 4h difluorophenylmethyl P1 ligand, crown-THF-derived...
The design, synthesis, X-ray structural, and biological evaluation of a series highly potent HIV-1 protease inhibitors are reported herein. These incorporate novel cyclohexane-fused tricyclic bis-tetrahydrofuran as P2 ligands in combination with variety P1 P2' ligands. inhibitor difluoromethylphenyl ligand cyclopropylaminobenzothiazole exhibited the most antiviral activity. Also, it maintained activity against panel multidrug-resistant variants. corresponding an enantiomeric was...
Most pediatric tibial shaft fractures (75%)1 can be treated nonoperatively; however, unstable and open require surgical intervention. Titanium elastic nails have become a popular technique for fixation of fractures. They act as internal splints that impart relative stability to the fracture, promoting callus formation at fracture site2.After patient is placed in supine position, proximal physis marked using fluoroscopy. An anteromedial anterolateral incision are made distal physis. Entry...
There is limited information on the presentation and management of upper extremity septic arthritis (UESA) in children. Our purpose was to report characteristics short-term treatment outcomes pediatric UESA from a multicenter database.
Lateral condyle fractures are intra-articular injuries of the distal humerus and second most common elbow fracture in pediatric patients. When these involve significant displacement, anatomic reduction lateral fragment is commonly achieved using open techniques. Although a technique for closed has been proposed literature, an instructional, step-by-step description such yet to be published. We have built upon previously published by focusing on pathomechanism injury, with goal making...
Abstract Introduction Adolescent idiopathic scoliosis (AIS) is a common diagnosis managed by pediatric orthopedic surgeons with nonoperative radiographic monitoring representing cornerstone of treatment. Differences in practices and techniques for obtaining studies contribute to variation, cost care, hamper data aggregation. We surveyed several large organizations dedicated children’s orthopedics or care obtain consensus evaluation AIS. Methods A REDCap-based survey was developed across four...
<h3>Objective</h3> To describe persistent symptoms, concussion knowledge, and education patterns in Division-one student-athletes. <h3>Design</h3> Cross-sectional. <h3>Setting</h3> Qualtrics online survey. <h3>Participants</h3> Of the 475 Division-I student-athletes, 118 accessed survey (rate=24.8%) 1 declined consent (1/118=0.8%), 113 completed at least one part of (rate=95.8%). <h3>Interventions</h3> Respondents were invited to complete 5-minute titled '<i>Concussion Knowledge.'</i> The...
Introduction: Nonoperative care represents a cornerstone of adolescent idiopathic scoliosis (AIS) management, although no consensus exists for minimal data set. We aimed to determine in critical points obtain during clinical AIS visits. Methods: A REDCap-based survey was distributed Pediatric Orthopedic Society America (POSNA), Spine Study Group (PSSG), and International on Scoliosis Rehabilitation Treatment (SOSORT). Respondents ranked the importance history, physical examination, bracing...
A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed, synthesized and evaluated.