A5040862534- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Streptococcal Infections and Treatments
- Infectious Diseases and Tuberculosis
- Orthopaedic implants and arthroplasty
- Hematological disorders and diagnostics
- Musculoskeletal Disorders and Rehabilitation
- Venous Thromboembolism Diagnosis and Management
- Hip disorders and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Scoliosis diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Surgery and Rehabilitation
- Shoulder and Clavicle Injuries
- Trauma and Emergency Care Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bone health and osteoporosis research
- Surgical Simulation and Training
- Acute Myocardial Infarction Research
- Otolaryngology and Infectious Diseases
- Surgical site infection prevention
Mercy Hospital
2025
Boston Children's Hospital
2024
Vanderbilt University Medical Center
2017-2023
Monroe Carell Jr. Children's Hospital
2021
Vanderbilt University
2015-2018
Indiana University School of Medicine
2018
Michigan Medicine
2017
University Health System
2017
Creative Commons
2017
Vanderbilt Health
2016
Reports of low-quality pharmaceuticals have been on the rise in past decade, with greatest prevalence substandard medicines developing countries, where lapses manufacturing quality control or breaches supply chain allow to reach marketplace. Here, we describe inexpensive test cards for fast field screening pharmaceutical dosage forms containing beta lactam antibiotics combinations four first-line antituberculosis (TB) drugs. The devices detect active ingredients (APIs) ampicillin,...
Bone fractures create five problems that must be resolved: bleeding, risk of infection, hypoxia, disproportionate strain, and inability to bear weight. There have been enormous advancements in our understanding the molecular mechanisms resolve these after fractures, best clinical practices repairing fractures. We put forth a modern, comprehensive model fracture repair synthesizes literature on biology biomechanics address primary This updated is framework for both management future studies...
Current studies have examined the efficacy of opioid-sparing analgesics primarily in adult surgical populations, while fewer guide pediatric postoperative pain treatment. Caffeine exerts most its biological effects by binding to adenosine receptors, which are important for modifying and inflammation. Caffeine's ability modulate following posterior spinal fusion (PSF) adolescent idiopathic scoliosis (AIS) has not been previously assessed. The hospital investigational drug study (IDS) pharmacy...
Background: Musculoskeletal infections (MSKIs) are a common cause of pediatric hospitalization. Children affected by MSKI have highly variable hospital courses, which seem to depend on infection severity. Early stratification severity would therefore help maximize resource utilization and improve patient care. Currently, MSKIs classified according primary diagnoses such as osteomyelitis, pyomyositis, etc. These diagnoses, however, do not often occur in isolation may differ widely On the...
Introduction: Musculoskeletal infection (MSI) is a common cause of morbidity and hospital resource utilization in the pediatric population. Many physicians prefer to withhold antibiotics until tissue cultures can be taken an effort improve culture yields. However, there little evidence that this practice improves results or outcomes MSI. Therefore, investigating effects antibiotic timing may lead improved clinical guidelines for treating children with Methods: An IRB-approved retrospective...
➢ Tissue injury activates the acute-phase response mediated by liver, which promotes coagulation, immunity, and tissue regeneration. To survive disseminate, musculoskeletal pathogens express virulence factors that modulate hijack this response. As reactants required these are most abundant in damaged tissue, infections predisposed to occur tissues following traumatic or surgical injury. Staphylococcus aureus expresses coagulase von Willebrand binding protein stimulate coagulation form a...
Objective: There are currently no algorithms for early stratification of pediatric musculoskeletal infection (MSKI) severity that applicable to all types tissue involvement. In this study, the authors sought develop a clinical prediction algorithm accurately stratifies based on and laboratory data at presentation emergency department. Methods: An IRB-approved retrospective review was conducted identify patients aged 0 18 who presented department tertiary care children’s hospital with concern...
The rate of venous thromboembolism in children with musculoskeletal infections (MSKIs) is markedly elevated compared hospitalized general. Predictive biomarkers to identify high-risk patients are needed prevent the significant morbidity and rare mortality associated thrombotic complications. We hypothesize that overactivation acute phase response development pathologic thrombi we aim determine whether elevations C-reactive protein (CRP) increased rates thrombosis pediatric MSKI.A...
Abstract Background Prior studies of pediatric musculoskeletal infection have suggested that methicillin-resistant Staphylococcus aureus (MRSA) infections result in worse outcomes compared with methicillin-susceptible S (MSSA) strains. Based on these results, clinical prediction algorithms been developed to differentiate between MRSA and MSSA early a patient’s course. This study compares hospital for patients presenting the emergency department at large tertiary care children’s hospital....
Purpose Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) fibrinogen, have been used predict complications TKA, the extent duration of changes in albumin levels TKA are unknown. It is hypothesized that like CRP albumin, fibrinogen/albumin ratio (FAR) represent useful measures response (APR) TKA. The purpose this study was describe longitudinal course FAR healthy patients relative established...
In-service training examinations (ITEs) are used to assess residents across specialties. However, it is not clear how they integrated with the Accreditation Council for Graduate Medical Education Milestones and competencies.This study explored distribution of specialty-specific milestones competencies in ITEs plastic surgery orthopaedic surgery.In-service were publicly available (PSITE) orthopaedics (OITE). Questions on PSITE 2014-2016 OITE 2013-2015 mapped 6 competencies.There was an uneven...
Immediately following a fracture, fibrin laden hematoma is formed to prevent bleeding and infection. Subsequently, the organized removal of fibrin, via protease plasmin, essential permit fracture repair through angiogenesis ossification. Yet, when plasmin activity lost, depletion alone insufficient fully restore repair, suggesting existence additional targets important for repair. Previously, activated matrix metalloproteinase 9 (MMP-9) was demonstrated function in by promoting angiogenesis....
To better describe the pathoanatomy of young patients' femoral neck fractures with goal improving surgeons' decisions for treatment including reduction and fixation.This is a retrospective study patient records, plain radiographs, modern computed tomography scans to Pauwels II III (coronal angle >30 degrees) in adults.One American College Surgeons Level 1 trauma center.All patients 18-49 years age surgically repaired Pauwels' (>30 fracture between 2013 2017.Fifty-six adult younger than 50...
Girdlestone's arthroplasty is an uncommon surgical procedure; it performed in patiens with recurrent infection of the hip, polymicrobic sepsis or after multiple revisions. The number hip replacements all over world always increasing, so total prosthesis infections also continues to rise, although relative incidence lower than past. For this reason must be a well-known procedure surgeons. Clinical assessment such patients cannot common ratings (e.g. Harris Hip Score) since instability, low...