A5113795718- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hematopoietic Stem Cell Transplantation
- Hip disorders and treatments
- Bone fractures and treatments
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Shoulder Injury and Treatment
- Bone and Joint Diseases
- Pulmonary Hypertension Research and Treatments
- Orthopedic Surgery and Rehabilitation
- Hemoglobinopathies and Related Disorders
- Spine and Intervertebral Disc Pathology
- Heterotopic Ossification and Related Conditions
- Opioid Use Disorder Treatment
- Mycobacterium research and diagnosis
- Shoulder and Clavicle Injuries
- Nerve Injury and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Tuberculosis Research and Epidemiology
- Acute Kidney Injury Research
- Clinical Reasoning and Diagnostic Skills
- HIV-related health complications and treatments
- Primary Care and Health Outcomes
Vanderbilt University Medical Center
2016-2025
Mayo Clinic
2018-2024
Monroe Carell Jr. Children's Hospital
2023
Tennessee Oncology
2023
Mayo Clinic in Arizona
2020-2022
Hackensack University Medical Center
2006-2021
WinnMed
2018-2020
Case Western Reserve University
2018
Vanderbilt University
2016-2017
Medical University of South Carolina
2017
Bone fractures create five problems that must be resolved: bleeding, risk of infection, hypoxia, disproportionate strain, and inability to bear weight. There have been enormous advancements in our understanding the molecular mechanisms resolve these after fractures, best clinical practices repairing fractures. We put forth a modern, comprehensive model fracture repair synthesizes literature on biology biomechanics address primary This updated is framework for both management future studies...
Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury major orthopedic surgery can result in pain and loss of joint function. The pathophysiology tissue calcification, including dystrophic calcification heterotopic ossification (HO), is poorly understood; consequently, current treatments are suboptimal. Here, we show that plasmin protease activity prevents injured skeletal muscle independent its canonical fibrinolytic After injury,...
Training physicians to be effective practitioners throughout their careers begins in undergraduate medical education with particular focus on self-directed inquiry, professional and interprofessional development, competency-based assessment. A select number of schools are restructuring curricula by placing the student at center content delivery enhance learning experience. While this may benefit adult learner, administrators often make assumptions about how students will perceive respond...
Pediatric allogeneic stem cell transplant (AlloSCT) patients are at substantial risk of developing kidney injury (KI), and KI contributes to transplant-related morbidity mortality. We compared the estimated creatinine clearance (eCrCl) 1, 3, 6, 9, 12 months post-AlloSCT in 170 following reduced toxicity conditioning (RTC) versus myeloablative (MAC) baseline. eCrCl was calculated using Schwartz equation. Patients with ≥50% drop from baseline were considered have KI. received tacrolimus...
BackgroundSocioeconomic disadvantage has been associated with negative outcomes following total hip arthroplasty (THA) and knee (TKA). The area deprivation index (ADI) distressed communities (DCI) are composite rankings that score socioeconomic status (SES) using patients' home addresses. purpose of this study was to examine the association ADI DCI THA TKA while controlling for potential confounding covariates.MethodsA series 4,146 consecutive patients undergoing primary between January 2018...
Despite effective control of HIV infection with antiretroviral drugs, individuals have high incidences secondary diseases. These sequelae, such as cardiovascular disease (CVD), are poorly understood and represent a major health burden. To date, predictive biomarkers HIV-associated been elusive, making preventative clinical management essentially impossible. Here, we applied newly developed easy to deploy, multitarget, high-throughput glycomic analysis banked HIV+ human plasma samples...
Acquired aplastic anemia (AA) and myelodysplastic syndromes (MDS) are bone marrow (BM) failure with overlapping clinical features, at least a subset appears to share common pathophysiologic mechanisms. Recent studies of MDS have shown down-regulation genes involved in B-cell development decreased precursors (hematogones). We explored the possibility that AA, similar MDS, might also be associated defects lymphoid cells, especially B-cells, by using flow cytometry assess presence hematogones...
Purpose: The purpose of the study was to describe early complications and delayed shoulder complaints non-displaced or minimally displaced pediatric proximal humerus fractures treated non-operatively. Methods: Retrospective review all at a single institution from 2001 2016. Inclusion criteria were: AP axillary radiographs upon presentation final follow up, one up appointment, either fracture, open physis. Exclusion pathologic fractures, re-fractures, bone metabolic disorders. Patient...
Background: Data regarding opioid prescribing patterns following pediatric orthopaedic procedures is limited. The aim of this work was to evaluate the effects tiered guidelines for discharge prescriptions common procedures. Methods: Quality improvement project conducted at a single academic institution. Guidelines were implemented January 2018 and established 4 tiers increasing invasiveness 28 Patients who underwent these in 2017 comprised preguideline cohort (N=258), while patients treated...
Summary Background Children undergoing posterior spinal fusion experience high blood loss often necessitating transfusion. An appropriately activated coagulation system provides hemostasis during surgery, but pathologic dysregulation can cause progressive bleeding and increased transfusions. Despite receiving antifibrinolytics for clot stabilization, many patients still require Aims We sought to examine the association of dilutional coagulopathy with transfusion in pediatric scoliosis...
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity in children. The traditional treatment for curves greater than 50 degrees posterior fusion with pedicle instrumentation prevention of curve progression later life. However, there growing interest non-fusion techniques such as anterior vertebral body tethering. Despite presentation thoracolumbar and lumbar AIS, descriptions tethering AIS have been largely limited to thoracic vertebrae. goal this paper describe technique...
HCT leaves patients in a relative state of immune deficiency both during their initial transplant admission and for several years following discharge. NTM are generally harmless colonizers the outside environment, but immunocompromised patients, they can cause significant disease due to paucity T-cell defense. While routine prophylaxis against is recommended with low CD4 counts certain clinical settings (eg, AIDS), this not yet established despite higher risk.Here we build upon our prior...
Proximal humerus lesser tuberosity avulsions are uncommon injuries; however, when present, they can be debilitating for patients. As such, pose a unique clinical challenge. These fractures were traditionally treated through an open approach to the proximal humerus; arthroscopic techniques continue evolve and increasingly used these types of injuries. We describe our minimally invasive technique repair using standard equipment. This method is safe, efficient, applies basic shoulder techniques.
Background: Seymour fractures of the toe are physeal with often occult concomitant nail bed injuries and thus open fractures. They uncommon that without proper treatment can result in osteomyelitis. The literature has sparse information regarding clinical outcomes for these injuries. Methods: A single-center retrospective review included juxta-epiphyseal or Salter-Harris I/II fracture documented injury laceration. Clinical radiographic data were recorded consecutive primary outcome was...
Lateral condyle fractures are the second most common pediatric elbow fracture and at risk for malunion, nonunion or avascular necrosis. The Song Jakob classification guides management of complications. However, many lateral have accompanying bony soft tissue injuries, including dislocations, which not represented in current systems. Little is known about incidence outcomes these more complex injuries. purpose this study was to describe largest case series injuries characterize outcomes....