A5015765572- Gastric Cancer Management and Outcomes
- Cytomegalovirus and herpesvirus research
- Gallbladder and Bile Duct Disorders
- Microscopic Colitis
- Nutritional Studies and Diet
- Total Knee Arthroplasty Outcomes
- Colorectal Cancer Screening and Detection
- Venous Thromboembolism Diagnosis and Management
- Viral-associated cancers and disorders
- Orthopedic Infections and Treatments
- Global Cancer Incidence and Screening
- Clostridium difficile and Clostridium perfringens research
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Heterotopic Ossification and Related Conditions
- Burn Injury Management and Outcomes
- Multiple and Secondary Primary Cancers
- Radiation Effects and Dosimetry
- Herpesvirus Infections and Treatments
- Gestational Trophoblastic Disease Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Body Composition Measurement Techniques
- Cancer Risks and Factors
- Gastrointestinal Bleeding Diagnosis and Treatment
University of Tennessee at Chattanooga
2021-2025
University of Tennessee Health Science Center
2021-2024
Vanderbilt University Medical Center
2016-2021
Medical University of South Carolina
2016-2017
Cytomegalovirus (CMV) gastritis is a rare opportunistic infection that often affects immunosuppressed patients. It DNA virus belonging to the Herpes family most commonly spread through contaminated bodily fluids such as blood, urine, saliva, tears, breast milk, semen, and vaginal fluids. Here, we present case of newly diagnosed HIV-positive patient with acquired immunodeficiency syndrome (AIDS) found have gastroesophageal (GE) junction ulceration endoscopic characteristics suggestive...
Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury major orthopedic surgery can result in pain and loss of joint function. The pathophysiology tissue calcification, including dystrophic calcification heterotopic ossification (HO), is poorly understood; consequently, current treatments are suboptimal. Here, we show that plasmin protease activity prevents injured skeletal muscle independent its canonical fibrinolytic After injury,...
Dieulafoy lesions (DLs) are infrequent causes of gastrointestinal bleeding (GIB) but can cause hemorrhage with a high risk re-bleeds. They most noted in the stomach, this case series three colonic DLs highlights even more rare lower GIB. Three patients presented blood loss and were found to have DLs. All them had esophagogastroduodenoscopies (EGDs) that unremarkable, they subsequently underwent colonoscopy, which then showed oozing First, 63-year-old woman week maroon-colored stools no use...
Purpose Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) fibrinogen, have been used predict complications TKA, the extent duration of changes in albumin levels TKA are unknown. It is hypothesized that like CRP albumin, fibrinogen/albumin ratio (FAR) represent useful measures response (APR) TKA. The purpose this study was describe longitudinal course FAR healthy patients relative established...
Peri-articular injury may result in functional deficits and pain. In particular, post-traumatic elbow stiffness is a debilitating condition, precluding patients from performing activities of daily living. As such, clinicians basic scientists alike, aim to develop novel therapeutic interventions prevent treat stiffness; thereby reducing patient morbidity. Yet, there paucity pre-clinical models peri-articular stiffness, especially the upper extremity, necessary test efficacy therapeutics. We...
INTRODUCTION Burn and blast injuries present with serious risk for complications including fibrosis calcification of the soft tissues. Plasmin, active form plasminogen, is key serine protease responsible degradation fibrin (fibrinolysis). Our lab has previously shown that plasmin essential prevention muscle following injury. We hypothesized 1) plasminogen consumed in response to severe burn, 2) this transient deficiency impairs proper regeneration. METHODS To test our first hypothesis...
PURPOSE: Severe burn injury is associated with delayed or failed repair of skin and soft tissue. Following injury, impaired tissue healing occurs both at the site in concurrently injured with, but anatomically remote from, injury. Thus, predominate hypothesis that severe provokes derangements circulating acute phase reactants necessary for repair, contributing to pathologic changes healing. It has been determined failure remove fibrin, major constituent coagulation matrix, impairs all...
Introduction: Appalachia is a region that predominantly rural and encompasses 420 counties in the eastern United States. This marked by significant health disparities, poverty, low life expectancy. Studies have shown has higher overall incidence of colon rectal cancer. Recently, parts were identified as hotspots early-onset colorectal cancer (EOCRC) mortality decreased survival men. Nevertheless, regional rates characteristics EOCRC for are not been well described. Methods: retrospective...
Introduction: Kratom is an herbal supplement derived from Mitragyn speciosas, a plant closely related to coffee found in Southeast Asia. In indigenous regions, kratom used for psychoactive effects as well medicinal purposes. However, its are primarily responsible misuse worldwide. Recent data detailing the supplement’s potential dependence has led banning several southeastern countries. Studies performed due kratom’s growing popularity have demonstrated significant toxicity. Data shows that...
Introduction: Neuroendocrine tumors (NETs) are a subset of malignancies that arise from the neuroendocrine system. These often originate in gastrointestinal tract. Depending on functional status and their origin, these can induce symptoms related to cells which they arose. The most notable is carcinoid syndrome, seen embyonic midgut due secretory properties cells. Symptoms associated with syndrome include severe diarrhea, flushing, right-sided valvular heart disease. Although development...
Introduction: Since the 1990s, there has been an alarming rise in incidence and mortality of early onset colorectal cancer (EOCRC) US. While exact mechanism this is still unknown, have several proposed factors including obesity, diet, physical inactivity, environmental exposures. The food environment (FE) physical, economic, sociocultural context which populations obtain consume food. This first study to critically examine relationship environments, dietary patterns, costs with respect EOCRC...
Introduction: Helicobacter pylori is a bacteria that can infect the stomach lining. Most H. infections be asymptomatic but other times lead to various gastrointestinal conditions, including peptic ulcers and gastritis. Sometimes, long-term infection increases risk of developing cancer, particularly gastric adenocarcinoma. Case Description/Methods: A 43-year-old man with no significant past medical history presented progressive shortness breath, night sweats 50 pound weight loss over 6...
Introduction: Cytomegalovirus (CMV) commonly undergoes reactivation in the setting of immunosuppression leading to a wide range clinical manifestations. The most common CMV gastrointestinal manifestation is colitis. gastritis has also been recorded literature, although much more infrequent. This case discusses newly diagnosed HIV/AIDS patient found have malignant appearing GE Junction ulceration due absence esophagitis or underlying malignancy. Case Description/Methods: A 60-year-old woman...