A5023460159- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- BRCA gene mutations in cancer
- Dental Research and COVID-19
- Ethics and Legal Issues in Pediatric Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Genomics and Rare Diseases
- TGF-β signaling in diseases
- Cleft Lip and Palate Research
- Respiratory and Cough-Related Research
- Orthopedic Infections and Treatments
- Genetic factors in colorectal cancer
- Patient Dignity and Privacy
- SARS-CoV-2 detection and testing
- Ethics in Clinical Research
- Computational Drug Discovery Methods
- Pharmacological Receptor Mechanisms and Effects
- Respiratory Support and Mechanisms
- Sinusitis and nasal conditions
- Venous Thromboembolism Diagnosis and Management
- Craniofacial Disorders and Treatments
- RNA Interference and Gene Delivery
- Tumors and Oncological Cases
Vanderbilt University
2019-2023
Vanderbilt University Medical Center
2017-2023
Freie Universität Berlin
2008
The upper respiratory tract (URT) is the portal of entry severe acute syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with URT microbiome. However, understanding associations between microbiome severity disease 2019 (COVID-19) still limited.
Background & AimsChronic inflammation is a predisposing condition for colorectal cancer. Many studies to date have focused on proinflammatory signaling pathways in the colon. Understanding mechanisms that suppress inflammation, particularly epithelial cells, critical developing therapeutic interventions. Here, we explored roles of transforming growth factor β (TGFβ) family through SMAD4 colonic cells.MethodsThe Smad4 gene was deleted specifically adult murine intestinal epithelium. Colitis...
Response to the coronavirus disease 2019 (COVID-19) pandemic has primarily focused on pharmacologic and medical interventions, including antivirals,1 convalescent sera,2 vaccinations,3 with each potentially critical in fight against COVID-19, particularly among high-risk hospitalized populations. Non-hospitalized patients mild moderate comprise an estimated 81% of those affected COVID-19,4 there are currently no widely available interventions proven ability hasten symptom resolution or...
Little is known about the relationships between symptomatic early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load and upper airway mucosal gene expression immune response. To examine association of SARS-CoV-2 with expression, we profiled host transcriptome from nasopharyngeal swab samples 68 adults symptomatic, mild-to-moderate disease 19 (COVID-19). We measured using reverse transcription-quantitative PCR (RT-qPCR). then examined detected in all recovered >80% genome...
Abstract Background Little is known about the impact of reclassification on patients’ perception medical uncertainty or trust in genetics‐based clinical care. Methods Semistructured telephone interviews were conducted with 20 patients who had received a reclassified genetic test result related to hereditary cancer. All participants undergone counseling and testing for cancer susceptibility at Vanderbilt‐Ingram Cancer Center Hereditary Clinic within last six years. Results Most did not...
To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus responsible for disease 2019 (COVID-19) pandemic, on upper tract (URT) microbiota over time. fill this knowledge gap, we used 16S ribosomal RNA gene sequencing to characterize URT in 48 adults, including (1) 24 participants with mild-to-moderate COVID-19 who had serial mid-turbinate swabs collected up 21 days after enrolment and (2) asymptomatic, uninfected controls at only....
Abstract Patients at risk for hereditary cancer syndromes sometimes decline clinically appropriate genetic testing. The purpose of the current study was to understand what preferences, concerns, and desires informed their refusal as well level interest in being tested. We interviewed patients who had been seen a clinic Vanderbilt University Medical Center declined In all, 21 in‐depth, semi‐structured qualitative interviews were conducted. Although provided many reasons declining testing,...
Abstract Background The nose is the portal for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) infection, suggesting as a target topical antiviral therapies. purpose of this study was to assess both in vivo and vitro efficacy detergent‐based virucidal agent, Johnson Johnson's Baby Shampoo (J&J), SARS‐CoV‐2–infected subjects. Methods Subjects were randomized into three treatment groups: (1) twice daily nasal irrigation with J&J hypertonic saline, (2) saline alone, (3) no...
Purpose Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) fibrinogen, have been used predict complications TKA, the extent duration of changes in albumin levels TKA are unknown. It is hypothesized that like CRP albumin, fibrinogen/albumin ratio (FAR) represent useful measures response (APR) TKA. The purpose this study was describe longitudinal course FAR healthy patients relative established...
Annual albuminuria screening detects the early stages of nephropathy in individuals with diabetes. Because detection allows for interventions that lower risk developing chronic kidney disease, guidelines recommend annual testing all type 2 diabetes mellitus and those 1 at least 5 years. However, Eskind Diabetes Clinic Vanderbilt University Medical Center, occurred less frequently than desired.A quality improvement team first analysed clinic's processes, identifying lack a systematic approach...
Elbow fractures are the most common pediatric requiring operative treatment. To date, few studies have examined what annual factors drive elbow fracture incidence and no which severity or resource utilization. The goal of this study was to not only document patterns but also impact these on utilization in emergency department, medical service transportation, operating room (OR).Retrospective cohort 4414 from a single tertiary hospital (2007 2017). Exclusion criteria included outside...
Little is known about the relationships between symptomatic early-time SARS-CoV-2 viral load and upper airway mucosal gene expression immune response. To examine association of early with expression, we profiled host transcriptome from nasopharyngeal swab samples 68 adults symptomatic, mild-to-moderate COVID-19. We measured using qRT-PCR. then examined detected in all recovered >80% genome 85% COVID-19 adults. The respiratory virome was dominated by SARS-CoV-2, limited co-detection common...
Velopharyngeal insufficiency (VPI) results from defects interfering with closure of the velopharyngeal port. It can lead to many issues ranging nasal regurgitation severe speech abnormalities. Treatment is tailored patient-specific etiology and severity, often involving surgical correction. A rare, therefore seldom, described cause VPI isolated unilateral agenesis soft palate. We describe case a 2-year-old patient Stickler syndrome possessing unique anatomic presentation this pathology,...
Abstract Inflammation regulates many aspects of gut homeostasis but is also a key component colon cancer progression. While TGFβ signaling known to regulate inflammatory responses within immune cells, we have uncovered novel regulatory pathway in which and BMP suppress stimuli the colonic epithelium. Using mice with conditional deletion Smad4 intestinal epithelium, found that CCL20 expression was increased loss. Similarly, murine immortalized colonocytes human cell lines, blocking and/or...
Introduction Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm differentiating into primitive mesenchymal cells with partial skeletal muscle differentiation. It rare, especially in the sinonasal cavity. We review available literature on RMS and present case report involving spindle cell RMS, one of rarest subtypes. Case Report A 73-year-old man months right-sided epiphora nasal obstruction had abnormal calcification right cavity computed tomography. Nasal endoscopy revealed smooth,...
Abstract The nose is the portal for SARS-CoV-2 infection, suggesting as a target topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson’s Baby Shampoo (J&J) was tested virucidal agent in infected subjects. Twice daily irrigation of J&J hypertonic saline, saline alone, or no intervention were compared (n = 24/group). Despite demonstrated safety robust efficacy vitro assays, irrigations had impact on viral titers symptom scores treated subjects relative to...