A5067404874- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Music and Audio Processing
- Tracheal and airway disorders
- Gut microbiota and health
- Music Technology and Sound Studies
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 detection and testing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bladed Disk Vibration Dynamics
- Advanced machining processes and optimization
- Musicology and Musical Analysis
- Clostridium difficile and Clostridium perfringens research
- Vascular Anomalies and Treatments
- interferon and immune responses
- Respiratory Support and Mechanisms
- Speech Recognition and Synthesis
- Neuroscience and Music Perception
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Structural Health Monitoring Techniques
- Respiratory and Cough-Related Research
- Pharmacological Receptor Mechanisms and Effects
- Tumors and Oncological Cases
Vanderbilt University Medical Center
2020-2025
Dartmouth College
2008-2019
Birmingham VA Medical Center
1954
Abstract The Omicron variant of SARS‐CoV‐2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the may be less severe than those Delta variant. We sought to compare clinical outcomes these two strains, confirmed whole genome sequencing, over a short period time, from respiratory samples collected positive patients at large medical center. found significantly morbidity, including admission hospital and requirement for oxygen supplementation, mortality
The upper respiratory tract (URT) is the portal of entry severe acute syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with URT microbiome. However, understanding associations between microbiome severity disease 2019 (COVID-19) still limited.
Little is known about the relationships between symptomatic early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load and upper airway mucosal gene expression immune response. To examine association of SARS-CoV-2 with expression, we profiled host transcriptome from nasopharyngeal swab samples 68 adults symptomatic, mild-to-moderate disease 19 (COVID-19). We measured using reverse transcription-quantitative PCR (RT-qPCR). then examined detected in all recovered >80% genome...
ABSTRACT Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious mucosal scar. Diverse diseases in divergent organ systems are associated with fibrosis, suggesting common biologic mechanisms. One well characterized pathway chronic inflammation pathogen. In present study, we explored role microbiome iSGS pathogenesis. human samples,...
To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus responsible for disease 2019 (COVID-19) pandemic, on upper tract (URT) microbiota over time. fill this knowledge gap, we used 16S ribosomal RNA gene sequencing to characterize URT in 48 adults, including (1) 24 participants with mild-to-moderate COVID-19 who had serial mid-turbinate swabs collected up 21 days after enrolment and (2) asymptomatic, uninfected controls at only....
Abstract Background Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious mucosal scar. Disease rarity and wide geographic patient distribution has previously limited substantive mechanistic investigation into iSGS pathogenesis. Result By harnessing pathogenic mucosa from an international cohort single-cell RNA sequencing, we unbiasedly...
Immune checkpoint inhibitors (ICIs) are used for the treatment of numerous cancers, but risks associated with ICI-therapy during COVID-19 pandemic poorly understood. We report a case acute lung injury in cancer patient initially treated ICI-pneumonitis and later found to have concurrent SARS-CoV-2 infection. Post-mortem analyses revealed diffuse alveolar damage both organizing phases, predominantly CD68+ inflammatory infiltrate. Serum was positive anti-SARS-CoV-2 IgG, suggesting that viral...
Abstract Background The nose is the portal for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) infection, suggesting as a target topical antiviral therapies. purpose of this study was to assess both in vivo and vitro efficacy detergent‐based virucidal agent, Johnson Johnson's Baby Shampoo (J&J), SARS‐CoV‐2–infected subjects. Methods Subjects were randomized into three treatment groups: (1) twice daily nasal irrigation with J&J hypertonic saline, (2) saline alone, (3) no...
Little is known about the relationships between symptomatic early-time SARS-CoV-2 viral load and upper airway mucosal gene expression immune response. To examine association of early with expression, we profiled host transcriptome from nasopharyngeal swab samples 68 adults symptomatic, mild-to-moderate COVID-19. We measured using qRT-PCR. then examined detected in all recovered >80% genome 85% COVID-19 adults. The respiratory virome was dominated by SARS-CoV-2, limited co-detection common...
This article presents a new system for real-time machine listening within human-machine free improvisation. Heretic uses Anthony Braxton's Language Music as grammatical model contextualizing audio feature data hears, recognizes, and organizes unseen musical material from human improviser into fluid, coherent, expressive language. Systems similar to often prioritize agnostic approaches by avoiding prior knowledge in the system's training stage. However, prominent improvisers such Cecil...
This article presents a new system for real-time machine listening within human-machine free improvisation. Heretic uses Anthony Braxton's Language Music as grammatical model contextualizing audio feature data hears, recognizes, and organizes unseen musical material from human improviser into fluid, coherent, expressive language. Systems similar to often prioritize agnostic approaches by avoiding prior knowledge in the system's training stage. However, prominent improvisers such Cecil...
Abstract The nose is the portal for SARS-CoV-2 infection, suggesting as a target topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson’s Baby Shampoo (J&J) was tested virucidal agent in infected subjects. Twice daily irrigation of J&J hypertonic saline, saline alone, or no intervention were compared (n = 24/group). Despite demonstrated safety robust efficacy vitro assays, irrigations had impact on viral titers symptom scores treated subjects relative to...