A5022984651- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Streptococcal Infections and Treatments
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Hematological disorders and diagnostics
- Venous Thromboembolism Diagnosis and Management
- Heterotopic Ossification and Related Conditions
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Sarcoma Diagnosis and Treatment
- Hip and Femur Fractures
- Blood properties and coagulation
- Infectious Diseases and Tuberculosis
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Burn Injury Management and Outcomes
- Bone health and treatments
- Musculoskeletal Disorders and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Blood transfusion and management
- Bone health and osteoporosis research
Vanderbilt University Medical Center
2016-2025
Monroe Carell Jr. Children's Hospital
2014-2025
Vanderbilt University
2015-2024
Bipar
2014-2023
Tennessee Oncology
2023
Pediatrics and Genetics
2016-2022
Indiana University School of Medicine
2021
Children's Hospital & Medical Center
2020
Pain and Rehabilitation Medicine
2018-2019
Creative Commons
2017
Flexible intramedullary nailing (IMN) has become a popular technique for the management of unstable or open forearm fractures. Recent publications have suggested an increased incidence delayed union and poor outcomes in older children adolescents. The objective this study was to review fractures treated with IMN, comparing rate complications between 2 age groups. Our hypothesis that IMN is effective similar both groups.An Institutional Review Board-approved retrospective conducted pediatric...
Bone formation during fracture repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix. In addition to central role in hemostasis, fibrin is thought enhance bone by supporting inflammatory and mesenchymal progenitor egress into the zone injury. However, given that failure efficient clearance can impede normal wound repair, precise contribution whether supportive detrimental, unknown. Here, we employed mice with genetically pharmacologically imposed...
Bone fractures create five problems that must be resolved: bleeding, risk of infection, hypoxia, disproportionate strain, and inability to bear weight. There have been enormous advancements in our understanding the molecular mechanisms resolve these after fractures, best clinical practices repairing fractures. We put forth a modern, comprehensive model fracture repair synthesizes literature on biology biomechanics address primary This updated is framework for both management future studies...
With the recent interest of protease-activated receptors (PAR) 1 and PAR4 as possible targets for treatment thrombotic disorders, we compared efficacy receptor (PAR)1 in generation procoagulant phenotypes on platelet membranes. PAR4-activating peptide (AP)-stimulated platelets promoted thrombin plasma up to 5 minutes earlier than PAR1-AP-stimulated platelets. PAR4-AP-mediated factor V (FV) association with surface was 1.6-fold greater PAR1-AP. Moreover, stimulation resulted a 3-fold release...
ABSTRACT Osteosarcoma is the most common primary malignant tumor of bone and accounts for around 50% all skeletal malignancies. In addition to novel chemotherapies, there a need adjuvant therapies designed inhibit osteosarcoma proliferation tumor-induced osteolysis attenuate expansion metastasis. As such, studies on efficacy bisphosphonates human are planned after feasibility determined that bisphosphonate zoledronic acid (ZOL) can be safely combined with conventional chemotherapy. However,...
Abstract Osteosarcoma is the most common primary bone malignancy and accounts for more than half of skeletal malignancies in children young adults. Although vascular endothelial growth factor (VEGF) expression osteosarcoma has been associated with poor outcome, its role pathogenesis remains controversial. Here, VEGF VEGFR1 both human murine cells increasing malignant potential. Autocrine VEGF/VEGFR1 signaling resulted constitutive activation highly aggressive cells. In addition, survival...
Background: Accurately determining the presence and severity of pediatric musculoskeletal infection (MSKI) is crucial for effective triage treatment. Although white blood-cell (WBC) count often used as a marker MSKI, we hypothesized that use WBC limited by age-related variability in children. We proposed absolute neutrophil-to-lymphocyte ratio (NLR), which has less variability, more reliable indicator both diagnosing assessing MSKI. The present study aims to compare utility against NLR, well...
Background: The yield of synovial fluid cultures in patients meeting clinical criteria for septic hip arthritis remains low. In the presence positive blood cultures, these are diagnosed and treated as “presumed arthritis.” We hypothesized that some may instead have an extra-articular infection, such pericapsular pyomyositis. Methods: An IRB-approved prospective study children with suspected at a tertiary care children’s hospital over 2-year time period was conducted. Children were evaluated...
Maxillary hypoplasia occurs due to insufficient maxillary intramembranous ossification, leading poor dental occlusion, respiratory obstruction and cosmetic deformities. Conditional deletion of Jagged1 (Jag1) in cranial neural crest (CNC) cells using Wnt1-cre; Jagged1(f/f) (Jag1CKO) led characterized by intrinsic differences bone morphology density μCT evaluation. Jag1CKO maxillas revealed altered collagen deposition, delayed reduced expression early late determinants osteoblast development...
Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury major orthopedic surgery can result in pain and loss of joint function. The pathophysiology tissue calcification, including dystrophic calcification heterotopic ossification (HO), is poorly understood; consequently, current treatments are suboptimal. Here, we show that plasmin protease activity prevents injured skeletal muscle independent its canonical fibrinolytic After injury,...
Osteoporosis is a skeletal disorder characterized by low bone mass and increased fragility associated with aging, menopause, smoking, obesity, or diabetes. Persistent inflammation has been identified as an instigating factor in progressive loss. In addition to the role of fibrin coagulation, inordinate deposition within tissue matrix results local inflammation. Given that accumulation hallmark osteoporosis-related comorbidities, we undertook this study test hypothesis persistent causes...
Slipped capital femoral epiphysis (SCFE) is strongly associated with childhood obesity, yet the prevalence of obesity orders magnitude greater than SCFE. Therefore, it hypothesized that not, by itself, a sufficient condition for SCFE, but rather one component multifactorial process requiring preexisting physeal pathology. Leptin elevation seen to varying degrees in patients and as leptin has been shown cause pathology similar changes we propose may be factor distinguishing between SCFE...
Key Points TXA is an active-site inhibitor of uPA. attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity.
Fibrinolysisis is essential for vascular blood flow maintenance and triggered by endothelial platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (ARF) trauma, the fibrinolytic response reduced may lead to widespread thrombosis multi-organ failure. The mechanisms underpinning fibrinolysis resistance include t-PA expression and/or release, plasmin effect due elevated inhibitor levels, increased consumption clearance....
The purpose of this study was to compare hemiepiphysiodesis implants for late-onset tibia vara and evaluate patient characteristics that may predict surgical failure.This is a retrospective review patients treated with temporary from 1998 2012. Mechanical axis deviation (MAD), mechanical angle, lateral distal femoral medial proximal tibial angle were measured on standing bone length radiographs. Surgical failure defined as residual deformity requiring osteotomy, revision surgery, or MAD...