A5011269996- Platelet Disorders and Treatments
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Blood disorders and treatments
- Cell Adhesion Molecules Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Myocardial Infarction Research
- Muscle and Compartmental Disorders
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Intramuscular injections and effects
- Inflammatory Biomarkers in Disease Prognosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ubiquitin and proteasome pathways
- Chronic Myeloid Leukemia Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Adenosine and Purinergic Signaling
- Central Venous Catheters and Hemodialysis
The University of Sydney
2014-2024
Oxford University Hospitals NHS Trust
2023-2024
St Vincent's Hospital Sydney
2018-2023
UNSW Sydney
2023
St Vincent's Health
2023
Royal North Shore Hospital
2014-2022
Lismore Base Hospital
2019-2022
Northern Sydney Local Health District
2019-2022
Faculty of 1000 (United States)
2019
ACT Government
2013-2016
Consistent with the biochemistry of coronaviruses as well established over decades, SARS-CoV-2 makes its initial attachment to host cells through binding spike protein (SP) sialylated glycans (containing monosaccharide sialic acid) on cell surface. The virus can then slide and enter via ACE2. SP attaches particularly tightly trillions red blood (RBCs), platelets endothelial in human body, each very densely coated acid surface molecules but having no ACE2 or minimal These interlaced...
Fibrinolysisis is essential for vascular blood flow maintenance and triggered by endothelial platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (ARF) trauma, the fibrinolytic response reduced may lead to widespread thrombosis multi-organ failure. The mechanisms underpinning fibrinolysis resistance include t-PA expression and/or release, plasmin effect due elevated inhibitor levels, increased consumption clearance....
Introduction Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder that occurs following the administration of heparin and caused by antibodies to platelet factor 4 heparin. Diagnosis HIT essential guide treatment strategies using non-heparin anticoagulants avoid unwanted potential fatal thromboembolic complications. This consensus statement, formulated members Thrombosis Haemostasis Society Australia New Zealand, provides an update on pathogenesis guidance diagnosis management...
Abstract Introduction Mean platelet volume ( MPV ) assists the differential diagnosis of inherited thrombocytopenia IT but lacks standardisation and varies between automated analysers. Classification based on mean diameter MPD has been proposed by an international collaborative study not validated. Methods To assess applicability to classify forms , digital images blood films from patients with established genetic causes for were generated, measured ZEISS Axio‐scanner Image J software) a...
MYH9-related disorders (MYH9-RDs) caused by mutation of the MYH9 gene which encodes non-muscle myosin heavy-chain-IIA (NMMHC-IIA), an important motor protein in hemopoietic cells, are most commonly encountered cause inherited macrothrombocytopenia. Despite distinguishing features including autosomal dominant mode inheritance, giant platelets on peripheral blood film accompanied leucocytes with cytoplasmic inclusion bodies (döhle-like bodies), these remain generally under-recognized and often...
Essentials•Platelet function defects may cause atypical bleeding symptoms in immune thrombocytopenia (ITP).•An isolated platelet defect of collagen‐induced aggregation was explored a patient with ITP.•ITP mediated by antibodies to glycoprotein (GP) VI curtail receptor function.•Inclusion GPVI diagnostic antibody detection assays improve their utility.ACKNOWLEDGEMENTSThe authors acknowledge excellent laboratory assistance from Ms. Christine Lee and Anila Jahangiri.Idiopathic (ITP) is an...
Consistent with the biochemistry of coronaviruses as well established over decades, SARS-CoV-2 makes its initial attachment to host cells through binding spike protein (SP) sialylated glycans (containing monosaccharide sialic acid) on cell surface. The virus can then slide and enter via ACE2. SP attaches particularly tightly trillions red blood (RBCs), platelets endothelial in human body, each very densely coated acid surface molecules but having no ACE2 or minimal These interlaced...
Abstract Idiopathic systemic capillary leak syndrome ( SCLS ) is extremely rare but carries a high morbidity and mortality. The diagnosis made clinically by classic triad of hypotension, hypoalbuminaemia haemoconcentration. There have been recent advances in understanding the pathophysiological basis for effective prophylaxis. We report case to increase awareness condition highlight benefits prophylactic intravenous immunoglobulin this condition.
Growth factor-independent 1B (GFI1B) on the long arm of chromosome 9 encodes GFI1B transcription factor, a member GFI zinc (Zn)-finger transcriptional repressor family which plays pivo...
Nilotinib is a second generation tyrosine kinase inhibitor, used in the treatment of chronic myelogenous leukaemia (CML).We assessed 72-year-old woman who was treated with nilotinib for CML.During year following commencement nilotinib, patient developed eight squamous cell carcinomas (SCCs) on her legs.Development SCC previously unreported adverse reaction to nilotinib.
Variants of the Diaphanous-Related Formin 1 (DIAPH-1) gene have recently been reported causing inherited macrothrombocytopenia. The essential/"diagnostic" characteristics associated with disorder are emerging; however, robust and complete criteria not established. Here, we report first cases DIAPH1-related in Australia caused by autosomal dominant gain-of-function DIAPH1 R1213X variant formed truncation protein within diaphanous auto-regulatory domain (DAD) loss regulatory motifs responsible...
The use of mean platelet diameter (MPD) to classify inherited thrombocytopenia (IT) has been demonstrated in several studies. Alternatively, the volume (MPV) may be used, but macrothrombocytopenia this not available. We hypothesized that forward scatter (FSC) measurements using flow cytometry used for size-based classification IT. study aimed assess ability FSC measure size and whether it could as an alternative MPD or MPV.Blood samples were obtained from individuals undergoing investigation...
Germline mutations of runt-related transcription factor-1 (RUNX1) cause familial platelet disorder with predisposition to myeloid malignancy (FPDMM), most commonly associated thrombocytopenia and propensity develop neoplasms. A key clinical question is which patients a family history should undergo genetic testing for
Abstract Background Surgery on cardiopulmonary bypass (CPB) elicits a pleiomorphic systemic host response which, when severe, requires prolonged intensive care support. Given the substantial cross‐talk between inflammation, coagulation, and fibrinolysis, aim of this hypothesis‐generating observational study was to document kinetics fibrinolysis recovery post‐CPB using ClotPro® point‐of‐care viscoelastometry. Tissue plasminogen activator‐induced clot lysis time (TPA LT, s) correlated with...