A5047202249- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer Risks and Factors
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Membrane Separation Technologies
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Health and Medical Research Impacts
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
- 14-3-3 protein interactions
- Immunotherapy and Immune Responses
- Pelvic and Acetabular Injuries
Gosford Hospital
2021-2025
University of Newcastle Australia
2022-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
The University of Texas Health Science Center at Houston
2025
Ministry of Agriculture and Rural Affairs
2025
Sichuan Agricultural University
2025
The University of Sydney
2019-2025
Chronic lymphocytic leukaemia (CLL) is associated with immunocompromise and high risk of severe COVID-19 disease mortality. Monoclonal B-cell lymphocytosis (MBL) patients also have immune impairment. We evaluated humoural cellular responses in 181 CLL (160) MBL (21) to correlate failed seroconversion [<50 AU/ml SARS-CoV-2 II IgG assay, antibody spike protein; Abbott Diagnostics)] following each two vaccine doses clinical laboratory parameters. Following first second doses, 79.2% then 45%...
Abstract Anaemia is a well‐recognised and widely accepted consequence of iron deficiency (ID); however, the two diagnoses are not synonymous with effects ID occurring long before development anaemia. In adults, can cause physical neuropsychological symptoms, including lethargy, altered mood poor concentration, reducing an individual's quality life. Foetal neonatal has been associated impaired neurocognitive lasting despite replacement in early Obstetric common, affecting up to 70% Australian...
Abstract With increasing availability of genetic tests, it is important to consider differences in testing patterns between population subgroups. We examined self-reported among 45,061 participants the Australian population-based 45 and Up Study, for associations with sociodemographic health characteristics (multivariable logistic regression). 9.2% reported ever having testing; 3.9% disease-related testing, 5.2% non-disease-related 0.7% both testing. Disease-related was strongly associated...
Abstract Background D‐‐ is a rare phenotype lacking the expression of C, c, E, and e antigens several high‐frequency on red cells. Anti‐Rh17 (Hr0) could be developed in individuals with to cause hemolytic transfusion reactions (HTR) disease fetus newborn (HDFN). Nuleotide(s) change RHCE gene RHCE‐D‐CE hybrid alleles are common molecular basis phenotype. Study Design Methods One Chinese patient detected routine RhD RhCE serologic testing another identified anti‐Rh17 were recruited. Further...
The metastatic process requires changes in tumor cell adhesion properties, motility and remodeling of the extracellular matrix. erbB2 proto-oncogene is overexpressed approximately 30% breast cancers a major prognostic parameter when present invasive disease. A ligand for receptor has not yet been identified but it can be activated by heterodimerization with heregulin (HRG)-stimulated erbB3 erbB4 receptors. HRGs are family polypeptide growth factors that have shown to play role embryogenesis,...
Colorectal cancer (CRC) screening improves survival and requires appropriate recommendation by general practitioners (GPs). Screening practises may be influenced barriers related to ethnicity training.A mail survey assessed GPs' the towards CRC screening. The association of demography, including GP ethnicity, medical training practise characteristics, were evaluated.Of 212 GPs (median age 54 years, 73% men, 27% Caucasian, 38% foreign graduates), 87% agreed that fecal occult blood test (FOBT)...
Summary Lymphoma in pregnancy (LIP) presents unique clinical, social and ethical challenges; however, the evidence regarding this clinical scenario is limited. We conducted a multicentre retrospective observational study reporting on features, management, outcomes of LIP patients diagnosed between January 2009 December 2020 at 16 sites Australia New Zealand for first time. included diagnoses occurring either during or within 12 months following delivery. A total 73 were included, 41...
Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment this disease. A hallmark IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, targeted deep DNA sequencing IGHV-IGHD-IGHJ regions has revealed intraclonal heterogeneity. We used approach achieves considerable depth minimizes artefacts amplification bias to identify subclones patients with prolonged temporal follow-up. Our findings...
Lymphoma in pregnancy is a rare and challenging diagnosis that complicates ∼1:6000 pregnancies; posing series of unique therapeutic, social, ethical challenges to the patient, her family, medical professionals involved. These difficulties are compounded by paucity real-world data on management LIP, lack relevant support systems for women this setting. We conducted retrospective multicenter qualitative study, interviewing aged ≥18 years age diagnosed with Hodgkin (HL) or non-Hodgkin lymphoma...
Germline mutations of runt-related transcription factor-1 (RUNX1) cause familial platelet disorder with predisposition to myeloid malignancy (FPDMM), most commonly associated thrombocytopenia and propensity develop neoplasms. A key clinical question is which patients a family history should undergo genetic testing for
<h3>Background</h3> There is an unmet need for predictive biomarkers immune check point inhibitors (ICI) in ccRCC. We previously showed that tumor PD-L1 expression and serum KIM-1 levels were independently associated with treatment effect adjuvant Nivolumab plus Ipilimumab (NIVO+IPI) vs placebo localized ccRCC Part A of Checkmate 914 (CM-914). Here we further investigated the role association response to NIVO+IPI B CM-914. In addition, explored a novel human-interpretable image feature-(IF)...