A5012455578- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Bone fractures and treatments
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Gastroesophageal reflux and treatments
- Glycosylation and Glycoproteins Research
- Eosinophilic Esophagitis
- Hip and Femur Fractures
- Immunotherapy and Immune Responses
- Abdominal Trauma and Injuries
- Genetics and Neurodevelopmental Disorders
- Trauma and Emergency Care Studies
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Gastrointestinal disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Diverticular Disease and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Congenital heart defects research
Vanderbilt University Medical Center
2013-2018
Vanderbilt University
2010-2018
Vanderbilt Health
2016
Allen Institute for Brain Science
2015
National Institutes of Health
2007
National Institute of Mental Health
2007
Virginia Commonwealth University
2002
AstraZeneca (Brazil)
2002
The mammalian target of rapamycin (mTOR) complex 2 (mTORC2) is a multimeric signaling unit that phosphorylates protein kinase B/Akt following hormonal and growth factor stimulation. Defective Akt phosphorylation at the mTORC2-catalyzed Ser473 site has been linked to schizophrenia. While human imaging animal studies implicate fundamental role for in prefrontal dopaminergic networks, molecular mechanisms linking specific schizophrenia-related neurotransmission abnormalities have not yet...
Noncardiac chest pain (NCCP) presents as a frequent diagnostic challenge, with patients tending to use disproportionate level of health care resources. Gastroesophageal reflux disease (GERD) is the most cause NCCP. Goals To test efficacy potent acid-suppressing agent in evaluation NCCP and compare it three commonly used tests. Study Eighteen men 24 women, aged 22 77 years, who presented recurrent complaints noncardiac etiology, determined by rest/stress perfusion imaging technetium Tc99m...
Insulin signaling in the central nervous system (CNS) regulates energy balance and peripheral glucose homeostasis. Rictor is a key regulatory/structural subunit of mTORC2 complex required for hydrophobic motif site phosphorylation Akt at serine 473. To examine contribution neuronal Rictor/mTORC2 to CNS regulation homeostasis, we utilized Cre-LoxP technology generate mice lacking all neurons, or either POMC AgRP expressing neurons. deletion neurons led increased fat mass adiposity,...
Little is known about genetic regulation of the development white matter. This knowledge critical in understanding pathophysiology neurodevelopmental syndromes associated with altered cognition as well elucidating genetics normal human cognition. The hemideletion approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes regulate cytoskeletal dynamics neurons, especially LIMK1 and CYLN2, therefore offers opportunity to investigate role these formation matter...
Disrupted neuronal protein kinase B (Akt) signaling has been associated with dopamine (DA)-related neuropsychiatric disorders, including schizophrenia, a devastating mental illness. We hypothesize that proper DA neurotransmission is therefore dependent upon intact Akt function. activated by phosphorylation of two key residues: Thr308 and Ser473. Blunted at Ser473 (pAkt-473) observed in lymphocytes postmortem brains schizophrenia patients, psychosis-prone normal individuals. Mammalian target...
Objective We have previously demonstrated that insulin signaling, through the downstream signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine-tunes (DA) at synapse. This suggests mechanism by impaired neuronal receptor hallmark diet-induced obesity, may contribute to DA transmission. tested whether short-term (two-week) obesogenic high-fat (HF) diet could reduce striatal Akt marker central insulin, and blunt dopaminergic network responsiveness...
In recent decades, a large body of research has focused on the role nitric oxide (NO) in development cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). Literature searches were therefore conducted regarding NO vasospasm, specifically focusing donors, reactive nitrogen species, and peroxynitrite manifestation vasospasm. Based off assessment available evidence, two competing theories are reviewed One school thought describes deficiency due to scavenging by hemoglobin cisternal...
Thomsen-Friedenreich (TF) antigen belongs to the mucin-type tumor-associated carbohydrate antigen. Notably, TF is overexpressed in colorectal cancer (CRC) but rarely expressed normal colonic tissue. Increased expression associated with tumor invasion and metastasis. In this study, we sought validate a novel nanobeacon for imaging TF-associated CRC preclinical animal model. We developed characterized use fluorescence colonoscopy. vivo was performed on an orthotopic rat model of CRC. Both...
The present study investigated the immunoenhancing property of our newly designed nanovaccine, that is, its ability to induce antigen-specific immunity. This also evaluated synergistic effect a novel compound PBS-44, an α-galactosylceramide analog, in boosting immune response induced by nanovaccine. nanovaccine was prepared encapsulating ovalbumin (ova) and adjuvant within poly(lactic-co-glycolic acid) nanoparticles. Quantitative analysis data showed encapsulated vaccine physically...
The Thomsen-Friedenreich (TF) antigen is a tumor-associated consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report development multimodal imaging probe, tripolymer fluorescent nanospheres, whose was fabricated with peanut agglutinin (PNA) moieties as TF molecular recognition molecules. Here, demonstrate that probe able to detect in human tissues and differentiate from normal tissue. What most noteworthy regarding...