A5102655040- Hemoglobinopathies and Related Disorders
- Esophageal Cancer Research and Treatment
- Optical Imaging and Spectroscopy Techniques
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Photoacoustic and Ultrasonic Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Gastric Cancer Management and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Non-Invasive Vital Sign Monitoring
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Oral Health Pathology and Treatment
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Cardiac and Coronary Surgery Techniques
- Helicobacter pylori-related gastroenterology studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cardiac Valve Diseases and Treatments
- Digital Radiography and Breast Imaging
- Acute Ischemic Stroke Management
- Mechanical Circulatory Support Devices
- Iron Metabolism and Disorders
University of California, Irvine
2010-2025
National Institutes of Health
2020-2024
University Medical Center HCMC
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2020-2023
Rice University
2012-2019
Baylor College of Medicine
2016
Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, form the backbone sound quality control procedures. We describe development testing a series optically turbid used in multi-center American College Radiology Imaging Network (ACRIN) trial Diffuse Optical Spectroscopic (DOSI). The ACRIN is designed to measure response breast tumors neoadjuvant chemotherapy. Phantom measurements determine absolute...
Microendoscopes allow clinicians to view subcellular features in vivo and real-time, but their field-of-view is inherently limited by the small size of probe's distal end. Video mosaicing has emerged as an effective technique increase acquired image size. Current implementations are performed post-procedure, which removes benefits live imaging. In this manuscript we present algorithm for real-time video using a low-cost high-resolution microendoscope. We execution times show results obtained...
Objectives/Hypothesis High‐resolution microendoscopy (HRME) provides real‐time visualization of the mucosal surface in upper aerodigestive tract. This technology allows noninvasive discrimination benign and neoplastic epithelium has potential applications for intraoperative margin detection. Study Design Single institution, prospective, feasibility trial (phase I) vivo optical imaging. Methods The study was conducted on patients with squamous cell carcinoma images obtained during surgery...
Cervical cancer is the third leading cause of cancer-related death among women in low-to-middle income countries. Pap testing and pathological services are difficult to implement under these settings. Alternative techniques for diagnosis cervical precancer settings needed reduce burden disease. The objective this study was evaluate diagnostic accuracy a low-cost, high-resolution microendoscope imaging system identifying precancerous lesions cervix vivo. A retrospective 59 patients undergoing...
Abstract The 5-year survival rate for patients with oral cancer remains low, in part because diagnosis often occurs at a late stage. Early and accurate identification of high-grade dysplasia can help improve patient outcomes. Multimodal optical imaging is an adjunctive diagnostic technique which autofluorescence used to identify high-risk regions within the cavity, followed by high-resolution microendoscopy confirm or rule out presence neoplasia. images were obtained from 206 sites 100...
Nearly 90% of cervical cancer cases and deaths occur in low- middle-income countries that lack comprehensive national HPV immunization screening programs. In these settings, it is difficult to implement programs due a infrastructure shortage trained personnel. Screening based on visual inspection with acetic acid (VIA) have been successfully implemented some low-resource settings. However, VIA has poor specificity up patients receiving treatment positive exam are over-treated. A number...
Oral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect biopsy OPLs and assess them for dysplasia, a marker increased risk. However, it is challenging decide which need select site. We developed multimodal optical imaging system (MMIS) that fully integrates the acquisition, display, analysis macroscopic white-light (WL), autofluorescence (AF), high-resolution microendoscopy (HRME) images noninvasively evaluate OPLs....
Transoral robotic-assisted oncologic surgery of the head and neck offers promising functional results. Nonetheless, efficacy remains critically dependent on obtaining negative margins. We aimed to integrate a miniaturized high-resolution fiber-optic microendoscope (HRME), which provides real-time histological assessment, with da Vinci robotic system (Intuitive Surgical, Sunnyvale, CA).Three patients undergoing transoral (TORS) were prospectively enrolled in this study. Optical imaging...
Thomsen-Friedenreich (TF) antigen belongs to the mucin-type tumor-associated carbohydrate antigen. Notably, TF is overexpressed in colorectal cancer (CRC) but rarely expressed normal colonic tissue. Increased expression associated with tumor invasion and metastasis. In this study, we sought validate a novel nanobeacon for imaging TF-associated CRC preclinical animal model. We developed characterized use fluorescence colonoscopy. vivo was performed on an orthotopic rat model of CRC. Both...
The goal of this study is to identify non-invasive optical hemodynamic biomarkers that can index laboratory hematology measurements in sickle cell disease (SCD). We acquired frequency-domain NIRS (FD-NIRS) and diffuse correlation spectroscopy (DCS) data from the forearms foreheads 17 participants a randomized, double-blind, placebo-controlled trial evaluating effects isoquercetin (IQ) on thromboinflammation SCD. observed multiple, significant correlations between including cerebral tissue...
Frequency-domain near infrared spectroscopy (fd-NIRS) is used to noninvasively characterize in vivo tissue structure and molecular composition by exploiting the deep penetration of red near-infrared light. However, size, complexity, expense, lack scalability current fd-NIRS hardware has slowed its translation clinical applications. Here we present a broad-bandwidth 1.2 x mm application-specific integrated circuit that represents critical step toward ultrasmall, easily scalable, wearable...
Ongoing multi-center clinical trials are crucial for Biophotonics to gain acceptance in medical imaging. In these trials, quality control (QC) and assurance (QA) key success provide "data insurance". Quality deal with standardization, validation, compliance of procedures, materials instrumentation. Specifically, QC/QA involves systematic assessment testing materials, instrumentation performance, standard operating data logging, analysis, reporting. QC QA important FDA accreditation by the...
Significance: Diffuse optical spectroscopic imaging (DOSI) is a versatile technology sensitive to changes in tissue composition and hemodynamics has been used for wide variety of clinical applications. Specific applications have prompted the development versions DOSI fit specific needs. This work describes characterization multi-modal (MM-DOSI) system that can acquire metabolic, compositional, pulsatile information at multiple penetration depths single hardware platform. Additionally, 3D...
Background: To determine the incidence of peripheral complications associated with cardiopulmonary bypass (CPB) and to detail cases severe necessitating surgical intervention during CPB at HCMC University Medicine Pharmacy Hospital. Material Methods: A cross-sectional, retrospective study on patients who underwent minimally invasive mitral valve surgery establishment between January 2017 2022. Results: Of 199 surgery, 24 (12%) experienced complications. The rates were as follows: femoral...
Wearable optical sensors can be used for non-invasive hemodynamic monitoring. Speckle-plethysmography (SPG) measures blood flow. We report on the use of SPG tracking changes in state an adult healthy population.
We optically characterize hemodynamic changes influenced by mitapivat, an oral pyruvate kinase activator, in 15 patients with sickle cell disease. Cerebral oxygen saturation increased above baseline within the first month of treatment and remained elevated.