A5000468440- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Influenza Virus Research Studies
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Respiratory and Cough-Related Research
- Congenital Heart Disease Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
Hospital of Hebei Province
2020-2025
Hebei Medical University
2020
Second Hospital of Hebei Medical University
2020
Flow Analysis (United States)
2017
China Medical University
2010-2011
Sheng Jing Hospital
2010
The increasing prevalence of severe Mycoplasma pneumoniae pneumonia (SMPP) poses a significant threat to the health children. This study aimed characterise and assess outcomes in children with SMPP.
Influenza virus is a contagious respiratory pathogen that can cause severe acute infections with long-term adverse outcomes. For paediatric patients at high risk of influenza, the readmission and associated factors remain unclear. Children discharged diagnosis or critical influenza from October 2021 to March 2022 were included. The disease severity was categorized according "2020 edition Chinese expert consensus on treatment in children". Demographic data, clinical characteristics,...
Abstract Background Acute respiratory infections (ARI) are a threat to human health and survival, resulting in many paediatric hospitalisations. However, the epidemiological clinical severity characteristics of parainfluenza virus (PIV), one most prevalent viruses, not well understood children. Methods To identify features PIV infection, 2019, hospitalised children with ARI were screened using multiplex polymerase chain reaction (PCR) for 10 other common pathogens. Subtyping randomly...
Abstract Background In this retrospective study, we aimed to evaluate the factors associated with severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted Children’s Hospital Hebei between June 2018 and January 2019. Methods Sputum samples positive for RSV via multiplex PCR subtyped using real-time PCR. Data collected included risk disease severity, demographics, microbiology, outcomes. Results Of 82 bronchiolitis, 79 treated discharged...
The treatment role of flexible bronchoscopy (FOB) for pediatric refractory Mycoplasma pneumoniae pneumonia (RMPP) has been well documented. Besides, the application indication FOB is also studied in patients with general MPP (GMPP), especially those large pulmonary lesions. This study was designed to examine diagnostic value bronchoscopic features RMPP.The and bronchoalveolar lavage (BAL) were adopted who showed clinical radiograph indications. On basis final diagnosis on discharge, divided...
Objective This study was performed to analyze 22 cases of Mycoplasma pneumoniae pneumonia (MPP) associated with bronchial casts (BCs) in children. Methods We retrospectively reviewed all MPP children treated at our institution from November 2015 December 2016. Demographic information, laboratory parameters, radiologic and fiberoptic bronchoscopy findings, treatment outcomes, follow-up results were analyzed. Results Among 161 patients MPP, had BCs 139 no BCs. All occurred a segmental or...
Abstract Background Community-acquired pneumonia (CAP) is usually diagnosed in children, and the type of respiratory specimen critical. Differences pathogens detection between induced sputum (IS) bronchoalveolar lavage fluid (BALF) have not been evaluated. Methods In 2018, paired BALF samples from CAP hospitalised children with indications for (BAL) were subjected to multiplex PCR 11 common pathogens. Results A total 142 tested. The overall positivity rate was 85.9% (122/142) 80.3% (114/142)...
Mycoplasma pneumoniae (MP) is the most common atypical pathogen that causes respiratory infections in children. Such are typically treated by macrolide antibiotics, but duration of treatment variable. In this study, we used nested PCR to amplify 16S rDNA (16S rRNA gene) MP at different stages pneumonia (MPP) 100 children who were admitted for lower tract and diagnosed with MPP. Our results indicate median MP-DNA positivity was 5 weeks, 78 % cases tested positive 3-6 weeks. Patients severe...
The contribution of the lung microbiota to pneumonia in children varying severity remains poorly understood. This study utilized metagenomic next-generation sequencing (mNGS) technology elucidate characteristics and their association with disease severity. retrospective analyzed bronchoalveolar lavage fluid (BALF) mNGS data 92 diagnosed between January 2021 July 2022. A comparative analysis was conducted severe (SP) (n = 44) non-severe (NSP) 48) groups. Compared conventional microbiological...
Objective To analyze the clinical manifestations of mycoplasma neumonia pneumonia blocked with glutinosity secretions from bronchioles. Methods Retrospective analysis was performed on data 51 children.The patients were divided into a group and an unblocked according performance flexible bronchoscopy.The manifestations, laboratory examination, radiological features bronchofibroscopic fin-dings children compared. Results The had 20 (7 boys 13 girls); 31 (16 15 girls). Compared...
Objective To explore the clinical application of FP-PCR method to detect MP-DNA.Methods Five hundred and sixty-three children suspected MP infection were enrolled in experimental group. was adopted MP-DNA. MP-DNA re-detected later 60 children. At same time,MP-Ab (MP antibody) detected by means particle agglutination. MP-Ab one or two weeks later. Also 20 healthy selected as control Results The positive rate 34. 99% 35.52% respectively,which showed no significant difference (x2 =0. 31, P > 0....
目的研究石家庄地区儿童严重急性呼吸综合征冠状病毒2（severe acute respiratory syndrome coronavirus 2，SARS-CoV-2）感染的流行病学特征。 方法根据河北省卫生健康委员会官网发布的信息，收集2021年1月2日至30日24时石家庄地区报道的确诊SARS-CoV-2感染的133例0~18岁儿童的流行病学资料，对患儿的一般情况、发病地区、有无聚集、核酸筛查阳性情况等进行统计分析。 结果133例SARS-CoV-2儿童感染病例中，男65例，女68例，男：女为0.96：1。最小发病年龄为3个月7 d，平均发病年龄为（9±5）岁。90例患儿为家庭成员中首发感染病例，占67.7%。发病地区主要在石家庄藁城区，共108例（81.2%）；其中源于首例确诊病例所在的小果庄村38例（28.6%）。疫情发生后第2周SARS-CoV-2核酸检测阳性88例（66.2%）；在核酸筛查阳性前仅5例有不适症状。疫情发生后进行SARS-CoV-2核酸筛查，首次筛查阳性仅19例（14.3%）；≥...