A5059644461- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Music Therapy and Health
- Neuroscience and Music Perception
- Cytomegalovirus and herpesvirus research
- Single-cell and spatial transcriptomics
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- CRISPR and Genetic Engineering
- Biomedical Ethics and Regulation
- Mesenchymal stem cell research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Atherosclerosis and Cardiovascular Diseases
- Hematopoietic Stem Cell Transplantation
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Action Observation and Synchronization
- Transgenic Plants and Applications
- Memory and Neural Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
University of Oxford
2017-2025
John Radcliffe Hospital
2020-2021
UK Dementia Research Institute
2019
University College London
2019
National Hospital for Neurology and Neurosurgery
2019
Oxford University Hospitals NHS Trust
2019
Oxford Research Group
2018
University of Oslo
2016
University of Nottingham
2015-2016
Abstract Spatial transcriptomics measures in situ gene expression at millions of locations within a tissue 1 , hitherto with some trade-off between transcriptome depth, spatial resolution and sample size 2 . Although integration image-based segmentation has enabled impactful work this context, it is limited by imaging quality heterogeneity. By contrast, recent array-based technologies offer the ability to measure entire subcellular across large samples 3–6 Presently, there exist no...
Adoptive transfer of antigen-specific regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. However, their low frequency peripheral blood poses challenges for both manufacturing clinical application. Chimeric antigen receptors (CARs) have been used redirect the specificity Tregs, employing retroviral vectors. gene costly, time consuming, raises safety issues. Here, we explored non-viral CRISPR-Cas12a editing using...
Memory for music has attracted much recent interest in Alzheimer's disease but the underlying brain mechanisms have not been defined patients directly. Here we addressed this issue an cohort using activation fMRI of two core musical memory systems. We studied 34 with younger onset led either by episodic decline (typical disease) or visuospatial impairment (posterior cortical atrophy) relation to 19 age-matched healthy individuals. designed a novel paradigm based on passive listening melodies...
Cell therapies have significant therapeutic potential in diverse fields including regenerative medicine, transplantation tolerance, and autoimmunity. Within these fields, regulatory T cells (Treg) been deployed to ameliorate aberrant immune responses with great success. However, translation of the cryopreservation strategies employed for other cell therapy products, such as effector therapies, Treg has challenging. The lack an optimized strategy products presents a substantial obstacle their...
Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these remain poorly characterized. Here we used music to probe rule decoding reward valuation patients with frontotemporal dementia (FTD) syndromes Alzheimer's disease (AD) relative healthy age-matched individuals. We created short melodies that were either harmonically resolved ('finished') or unresolved ('unfinished'); the task was classify each melody as finished...
I. Abstract Adoptive transfer of regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. Antigen-specific Tregs are more effective modulating undesired immune reactions, but their low frequency peripheral blood poses challenges for manufacturing clinical application. Chimeric antigen receptors (CARs) have been used redirect the specificity Tregs, employing retroviral vectors. However, gene costly, time consuming, raises...
Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial Treg therapy in living donor renal transplantation, the ONE Study (ClinicalTrials.gov: NCT02129881), we observed focal lymphocytic infiltrates protocol transplant biopsies that are not regularly seen patients receiving standard immunosuppression.
Vaginal delivery is recommended after intrauterine fetal death. However, little known about the risk of shoulder dystocia in these deliveries. We studied whether death increases at delivery.In this population-based register study using Medical Birth Registry Norway, we included all singleton pregnancies with vaginal offspring cephalic presentation Norway during period 1967-2012 (n = 2 266 118). Risk was estimated as absolute (%) and odds ratio 95% confidence interval. Adjustment made for...
Abstract The potential to harness regulatory T cells (Tregs) for the treatment of autoimmune diseases and transplant rejection has been restricted by several barriers: donor variability, manufacturing complications, time-consuming expansion processes. These issues further complicate use autologous Tregs during acute disease phases or when are low in number dysfunctional. Here we explore ‘off-the-shelf’ allogeneic Tregs, from healthy donors universal sources, provide a more practical...
Music is a universal stimulus that generates powerful emotion and reward. Responses to music depend on internalised ‘rules’ generate strong psychological expectancies have been little studied in disease. We assessed expectations generated while listening associated affective responses cohorts of patients with Alzheimer9s disease (AD) frontotemporal lobar degeneration (behavioural variant dementia (bvFTD), semantic (SD) progressive nonfluent aphasia (PNFA) relation healthy older individuals....
Music is a universal stimulus that generates powerful emotion and reward in listeners. Responses to music depend on internalised musical 'rules' generate strong psychological expectancies even musically untrained individuals. accesses brain mechanisms of emotion, rule encoding analogous those required for social relations targeted by dementia diseases. However, these aspects processing have been little studied neurodegenerative disease. Here we assessed cognitive expectations generated while...
A previously well fifteen-month-old female infant presented to a district general hospital in the United Kingdom with three-month history of virilisation developing facial acne, coarse pubic hair, labia majora hypertrophy, menstruation, and clitoral enlargement. functional adrenal tumour was suspected, supported by raised androgen metabolites on urinary steroid profile. An abdominal ultrasound scan identified unilateral left mass. subsequent CT her chest, abdomen, pelvis for surgical...
Vitamin D Receptor, STAT3, and TET2 Cooperate to Establish Tolerogenesis Català-Moll F, Ferrete-Bonastre A, Godoy-Tena G, et al. Cell Rep. 2022;38:110244. Establishing tolerance, a state of antigen-specific unresponsiveness in the absence immunosuppression, remains central focus transplantation research. Multiple approaches have been trialed, with mixed chimerism adoptive cellular transfer immune regulatory therapeutics among most promising. Several phase I trials are currently evaluating...
Background: Single cell RNA sequencing (scRNAseq) of tissue infiltrating leukocytes within human kidney transplants presents several technical challenges. For example, dissociation protocols may cause death or transcriptomic skewing, whilst creating single suspensions from freshly acquired biopsies is often impractical. Aims: 1) compare and optimise leukocyte yield three 2) evaluate the feasibility scRNAseq on cryopreserved transplant biopsies. Methods: Three digestion (cold, warm manual,...
Oxygenated Versus Standard Cold Perfusion Preservation in Kidney Transplantation (COMPARE): A Randomized, Double-blind, Paired, Phase 3 Trial Jochmans I, Brat A, Davies L, et al. Lancet. 2020;396:1653–1662. Maximizing the pool of available organs is a priority for transplantation community. Ex vivo organ perfusion has been focus significant research to minimize allograft damage between retrieval and implantation, fundamental principle being mechanical maintenance perfusate flow through...
Resumption of Cardiac Activity After Withdrawal Life-sustaining Measures Dhanani S, Hornby A, van Beinum, et al. N Engl J Med. 2021;384:345–352. Donations following circulatory death (DCD) contribute an ever increasing proportion organs available for transplantation, achieving comparable outcomes to those donated after brain stem death.1 The majority DCD donations occur in a “controlled” manner planned withdrawal life support intensive care setting. There is, however, geographic variability...