A5034833346- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Vitamin D Research Studies
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Obesity, Physical Activity, Diet
- Digestive system and related health
- Bone Metabolism and Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bone health and osteoporosis research
- Adrenal Hormones and Disorders
- Sexual Differentiation and Disorders
- Childhood Cancer Survivors' Quality of Life
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Genetic Syndromes and Imprinting
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Appendicitis Diagnosis and Management
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- TGF-β signaling in diseases
Medical University of Warsaw
2015-2024
Instytut Matki i Dziecka
2016-2017
Background Obesity is related to changes in adipokine secretion, activity of adipose tissue macrophages, helper T cells, and regulatory cells. It has been confirmed that vitamin D potent anti-inflammatory properties. contributes reduction pro-inflammatory mediators an increase cytokines. There also evidence could decrease C-reactive protein (CRP) affect selected haematological indices. Aim the Study We aimed evaluate effect on interleukin (IL)-10, IL-17, CRP, blood leukocyte profile,...
In the majority of countries autoimmune thyroiditis is main cause acquired hypothyroidism in children. Typically natural course disease initially insidious and diagnosis incidental. Simultaneously, there are some children who develop severe without a proper diagnosis. The aim study was to analyze clinical biochemical profile with primary due thyroiditis. Materials methods: We analyzed records 354 patients diagnosed between 2009 2019 Only TSH above 100 µIU/mL associated decreased free...
Neonatal hyperthyroidism mainly occurring in the children born to mothers with Graves' disease (GD). The influence of maternal GD on newborn's thyroid function includes not only hyperthyroidism, but also various forms hypothyroidism. Maternally transferred thyrotropin receptor antibodies (TRAb), antithyroid drug (ATD) administration during pregnancy and previous definitive treatment (radioactive iodine therapy or thyroidectomy) mother impact fetal/neonatal thyroid. Some newborns may present...
The relationships between bone turnover, the growth hormone/insulin-like factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. GH/IGF-1 can mutually modulate each other's metabolism influence activation of cell proliferation, maturation, mineralization as well resorption. aim this study was to evaluate reciprocal associations formation markers [alkaline phosphatase (ALP), alkaline (BALP)], 25-hydroxyvitamin [25(OH)D] in children with hormone deficiency at...
The aim of this study was to investigate the effects growth hormone (GH) therapy on thyroid function in a group euthyroid children with isolated idiopathic deficiency (GHD).
To assess the changes in leukocyte profile and C-reactive protein (CRP) concentration adolescents with excess fat mass after 6-12 months of dietary intervention.The retrospective study included 99 overweight obese adolescents, aged from 10.0 to 17.5 years, 82 whom were re-hospitalized 6 12 counseling. The control group consisted 42 normal weight peers. Anthropometric measurements laboratory tests performed, homeostasis model assessment - insulin resistance (HOMA-IR)...
Hypothyroidism in children leads to growth retardation. However, there is some evidence that recombinant human hormone (rhGH) therapy could suppress thyroid function. The most common observation rhGH-treated patients a decrease thyroxine levels, which reported as transient, but the studies field are inconsistent. We aimed evaluate function initially euthyroid with idiopathic isolated GH deficiency during long-term rhGH and determine who at higher risk of alterations therapy. study group...
Growth hormone (GH) affects carbohydrate metabolism through direct negative effect on insulin sensitivity and indirectly, via insulin-like growth factor-1 (IGF-1), which exerts positive insulin-mimetic action. The aim of this retrospective study was to evaluate the influence long-term GH treatment glucose homeostasis in 118 children with isolated idiopathic deficiency (GHD). Based analysis we wanted determine usefulness glycated haemoglobin (HbA1c) parameters derived from oral tolerance test...
Vitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence vitamin on chemerin levels.We aimed to investigate if there is a link between serum 25-hydroksyvitamin [25(OH)D], metabolic profile in overweight obese children before after supplementation.The prospective study included 65 aged 9.08-17.5 years 26 peers as control. None patients group...
Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal serum concentrations free thyroxine, suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children.Controversy remains, whether a thyroid dysfunction related to obesity has an influence on cardiovascular risk factors.The aim study was assess correlation between and thyroxine chosen atherogenic lipid indicators, carotid intima media thickness children...
This study investigated associations between the growth hormone/insulin-like factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before during 12 months of GH treatment. 23 short age-matched without hormone deficiency (GHD) or any genetic chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein (LDL-C), high-density (HDL-C),...
Assessment of the peripheral blood picture and aminotransferase activity in children with newly diagnosed Graves' disease (GD) at baseline 4-6 weeks after initiation antithyroid drug (ATD) therapy.Data 59 were assessed retrospectively. Baseline analysis included concentrations thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), thyroxine (fT4), TSH receptor antibodies (TSH-R Ab), complete cell count (CBC), aspartate (AST) alanine (ALT) activity. Reassessment CBC was performed ATD...
The authors present a case of 6-year-old boy operated on in the 4th week life because adrenal abscess. diagnosis an abscess neonatal period is challenging due to its rare occurrence and non-specific signs. Adrenal abscesses can develop via two mechanisms: as result hematogenic infection spread bacteria "normal" glands or, which much more common, complication hematoma. Early accurate crucial for appropriate therapeutic management. Imaging, including ultrasound, be problematic. final...
was to investigate the coincidence of growth hormone deficiency (GHD) and celiac disease (CD) or inflammatory bowel (IBD) in patients referred for short stature, evaluate baseline anthropometric parameters effectiveness recombinant human (rhGH) therapy first year those (GHD+CD/IBD subgroup) comparison with GHD without CD IBD (GHD-CD/IBD subgroup).