A5025436382- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
LFB (France)
2019
The long serum t1/2 of IgGs is ensured by their interaction with the neonatal Fc receptor (FcRn), which salvages IgG from intracellular degradation. glycosylation thought not to influence FcRn binding and longevity in vivo. In this article, we demonstrate that hypersialylation asparagine 297 (N297) enhances persistence. This polarized achieved using a novel mutation, glutamate residue deletion at position 294 (Del) endows an up 9-fold increase lifespan. strongest impact was observed when Del...
Plasmacytoid dendritic cells (pDCs) play a central role for both innate and adaptive antiviral responses, as they direct immune responses through their unique ability to produce substantial concentrations of type I interferon (IFNs) upon viral encounter while also activating multiple cells, including macrophages, DCs, B, natural killer T cells. Recent evidence clearly indicates that pDCs crucial in some cancers several auto-immune diseases. Although treatments are currently available...