A5101793615- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Hip and Femur Fractures
- Bone and Joint Diseases
- Bone health and treatments
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Axon Guidance and Neuronal Signaling
- Muscle Physiology and Disorders
- Cancer Risks and Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin C and Antioxidants Research
- Cancer Treatment and Pharmacology
- Medical and Biological Sciences
- Mesenchymal stem cell research
- Orthopedic Surgery and Rehabilitation
- Spinal Hematomas and Complications
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Alkaline Phosphatase Research Studies
- Heterotopic Ossification and Related Conditions
- Scoliosis diagnosis and treatment
- Genetic Syndromes and Imprinting
- Connective tissue disorders research
- Biomarkers in Disease Mechanisms
Saitama Medical University
2012-2024
Tokyo Metropolitan Tama-Hokubu Medical Center
2023
Social Insurance Saitama Chuo Hospital
2010-2022
Kyoto University
2010-2017
University of Occupational and Environmental Health Japan
2007-2009
Objective We have previously reported that stimulation of mouse bone marrow–derived macrophages with tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) induces differentiation osteoclast‐like cells. undertook this study to clarify the characterization function human TNF IL‐6–induced osteoclasts using peripheral blood collected from patients rheumatoid arthritis (RA) healthy donors. Methods Peripheral monocytes were cultured a combination IL‐6, alone, IL‐6 or RANKL, their resorption ability...
Daily and weekly administration of teriparatide (PTH1–34) reduces the risk osteoporotic bone fractures. However, their effects on markers formation resorption differ. These results indicate that dosing frequency may affect metabolism structure, with different strength. In present study, to evaluate dose-related a low status, we investigated three-times-weekly (1.1, 5.6, or 28.2 µg/kg) for 12 months parameters, including markers, mineral density (BMD), micro-computed tomography, strength,...
Bone is a highly vascularized organ, thus angiogenesis vital process during bone remodeling. However, the role of vascular systems in remodeling not well recognized. Here we show that netrin‐4 inhibits osteoclast differentiation vitro and vivo. Co‐cultures marrow macrophages with endothelial cells markedly inhibited differentiation. Adding neutralizing antibody, or RNA interference against netrin‐4, restored Administration prevented loss an osteoporosis mouse model by decreasing number. We...
Abstract Histone lysine methylation is thought to play a role in the pathogenesis of rheumatoid arthritis (RA). We previously reported aberrant expression gene encoding mixed-lineage leukemia 1 (MLL1), which catalyzes histone H3 4 (H3K4), RA synovial fibroblasts (SFs). The aim this study was elucidate involvement MLL1 activated phenotype RASFs. SFs were isolated from tissues obtained patients with or osteoarthritis (OA) during total knee joint replacement. mRNA and protein levels determined...
Evidence related to the effectiveness of combination drug therapy for treatment osteoporosis is currently considered insufficient. Therefore, this study was performed clarify effects monotherapy, and therapy, with a bisphosphonate (minodronic acid hydrate), bone resorption inhibitor, calcitonin (elcatonin), which effective alleviation pain due vertebral fractures in osteoporotic patients.Study participants comprised 51 female subjects post-menopausal osteoporosis, whose main complaint acute...
Abstract It is assumed that there are systemic changes in mineral metabolism during fracture healing may cause a predisposition to sequential fractures osteoporotic patients who suffered from previous fractures. Initial therapies for with important prevent disabilities daily life consequent bone and muscle atrophies, fractures, although local have not been well understood. We evaluated the effects of injury elcatonin injection as an initial therapy on turnover wound healing. Two drill holes...
Mechanical unloading induces bone loss in human weight-loaded bones. The findings of recent studies have revealed that cluster differentiation 38 knockout mice display similar to observed osteoporosis. This study aimed determine whether the expression is implicated skeletal and reloading.Eight-week-old male C57BL/6J were assigned control, tail-suspension, or reloading after tail-suspension groups. In group, tail suspension elevated hind limbs for 1 week. bilateral femurs tibias from groups...
ABSTRACT Endochondral ossification contributes to longitudinal skeletal growth. Osteoblasts, which are bone-forming cells, appear close terminally differentiated hypertrophic chondrocytes during endochondral ossification. We established mice with conditional knockout (cKO) of Smad4, an essential co-activator for transforming growth factor β family signaling. The showed a marked increase in bone volume the metaphysis as result increased formation by osteoblasts, β-catenin, effector canonical...
距骨外側突起骨折は比較的稀な骨折であり，初診時に見落とされることが多い．今回我々は，足関節外果剥離骨折を伴った距骨外側突起骨折を経験したので報告する．症例は67歳女性．平成17年4月，旅行中に階段を踏みはずし左足関節を背屈強制され受傷．同日近医受診．左足関節外果剥離骨折の診断にてシーネ固定され，2日後当院紹介受診．左足関節外果周囲の腫脹，疼痛，外果前面ならびに後面の圧痛を認めた．初診時単純 X 線像では，左足関節外果に剥離骨片を認めた．CT 再構築像にて距骨外側突起骨折も明らかとなった．後日外果部ならびに外側突起部を cancellous screw で整復固定した．術後3週目よりサポーター装着下にて部分荷重歩行を開始し，術後6週で1本杖歩行にて退院した．1年後抜釘し，経過良好である．距骨外側突起骨折は比較的稀な骨折で，しばしば見落とされる．今回我々が経験した症例は，診断に CT が有用であった．
Decline of body weight with aging is a major risk factor for frailty, osteoporosis and fracture, suggesting that treatment may affect composition. However, the effects on composition are not well known. The present study aimed to identify relationship between markers. We measured bone mineral density (BMD), composition, remodeling markers in 551 Japanese postmenopausal women Selective estrogen receptor modulators (SERMs) (SERM group; N = 143) treatment, bisphosphonates (BP 193) without by...
<h3>Background</h3> Previously, we reported that novel osteoclast-like cells (OLCs) were induced, both <i>in vitro</i> and vivo</i>, from mouse bone marrow-derived macrophages (BMMs) by addition of a combination TNFα IL-6<sup>1</sup>. Recently, O'Brien <i>et al</i> showed TNF/IL-6 can drive osteoclastogenesis in BMMs <i>RANK</i>-deficient mice<sup>2</sup>. <h3>Objectives</h3> We aimed to examine the differentiation OLCs, which induced IL-6 human peripheral blood mononuclear (PBMCs) CD14...