A5002997471- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Advanced Memory and Neural Computing
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Vagus Nerve Stimulation Research
- Histiocytic Disorders and Treatments
- Neural dynamics and brain function
- Dermatologic Treatments and Research
- Ocular Diseases and Behçet’s Syndrome
- Neurological disorders and treatments
- Ocular Oncology and Treatments
- Anesthesia and Sedative Agents
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Pregnancy and Medication Impact
- Parvovirus B19 Infection Studies
- Gaze Tracking and Assistive Technology
- Immunodeficiency and Autoimmune Disorders
Essen University Hospital
2000-2019
University of Duisburg-Essen
2004-2017
Carl-Thiem-Klinikum Cottbus
2005-2010
Universitätsklinik für Chirurgie Wien
2007
Augenklinik Heidelberg
2005
Medizinische Akademie Erfurt
1990
purpose. Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of neurons implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety efficacy a wireless intraocular implant (EPIRET3) six volunteers RP. methods. The is remotely controlled, fully device consisting receiver stimulator module. placed on surface. Data energy are transmitted via an inductive link from outside eye implant. Surgery included...
Abstract. Purpose: To determine the threshold charges needed for eliciting visual perceptions through acute electrical stimulation of human retina in patients suffering from retinitis pigmentosa, using an epiretinal microelectrode array. Methods: In a multicentre study, 20 (average age 55 years) with acuities ranging 4/200 to no light perception were included. The procedure was performed during pars plana vitrectomy, maximum 45 min, by microcontact film IrO x electrodes connected cable...
This paper reports on methods and technical equipment to investigate the epiretinal stimulation of retina in blind human subjects acute trials. Current is applied through a thin, flexible microcontact film (microelectrode array) with electrode diameters ranging from 50 360 microm. The mounted custom-designed surgical tool that hand-held by surgeon during stimulation. eventual goal work development chronically implantable retinal prosthesis restore useful level vision patients who are outer...
PURPOSE: To record the spectral transmittance curves of various ultraviolet (UV) and blue-light-filtering intraocular lenses (IOLs), evaluate their UV blue-light-radiation– absorption capacities, compare them with those natural crystalline lens. SETTING: Department Ophthalmology, Duisburg-Essen University, Essen, Germany. METHODS: Eight IOLs from 6 manufacturers were evaluated. The wavelengths 200 nm to 800 was measured using a high-performance spectrophotometer diffuse accessory through 1.5...
To evaluate the technique, safety, and efficacy of retropupillary implantation iris-claw intraocular lenses in a long-term follow-up study.This retrospective study included 31 eyes patients who underwent an Artisan aphakic lens between January 2006 February 2011 at University Hospital Essen, Germany Zentrum für Augenheilkunde PD Dr Laube, Düsseldorf, Germany. Preoperative data collected demographics, etiology aphakia, previous surgeries, preoperative eye pathology, pressure, clinical signs...
Abstract Background Retinal implants have been developed to treat blindness causing retinal degenerations such as Retinitis pigmentosa (RP). The stimulators are covering only a small portion of the retina usually in its center. To restore not central vision but also useful visual field need cover larger area retina. However, large much more difficult implant into an eye. Some basic questions concerning this challenge should be answered series experiments. Methods Large were fabricated...
Objective To investigate the incidence and risk factors for retinal detachment (RD) after cataract surgery or refractive lens exchange (RLE) in patients aged below 61 years. Methods Retrospective medical chart review of 7,886 (13,925 eyes) who underwent RLE. Patients years were selected. Age, gender, axial length, follow-up times, occurrence RD recorded. Additional characteristics documented cases were: history RD, preexisting findings, laser capsulotomy, status macula at date details RD....
The restoration of vision in blind patients suffering from degenerative retinal diseases like retinitis pigmentosa may be obtained by local electrical stimulation with implants. In this study, a very large electrode array for (VLARS) was introduced and tested regarding its safety implantation biocompatibility. Further, the array's capabilities were an acute setting.The polyimide-based implants have diameter 12 mm, cover approximately 110 mm2 surface carrying 250 iridium oxide coated gold...
To assess the long-term effect of acetazolamide treatment on patients with cystoid macular edema (CME) in course intermediate or posterior chronic uveitis and to define those who may particularly benefit from drug.Fifty-two eyes (45 patients) uveitic CME were treated at an initial dosage 500 mg/d. The was assessed by fluorescein angiography, ophthalmoscopy, visual acuity, Amsler testing. Therapy withdrawn when did not improve 3 weeks. In cases improvement, gradually tapered.The mean...
To describe options for vitreoretinal surgery in the management of massive suprachoroidal hemorrhage (SCH).Visual acuity (VA), ocular findings, timing surgical intervention, procedures, and outcomes four patients diagnosed with SCH admitted to University Eye Clinic Essen were reviewed retrospectively.Four eyes (mean age, 82 years; range, 74-89 years) studied. In three cases occurrence was related cataract occurred intra- or postoperatively. One patient developed spontaneous unclear origin....
To compare keratocyte loss in the corneal stroma after laser-assisted subepithelial keratectomy (LASEK) and photorefractive (PRK) rabbits.Department of Ophthalmology, University Essen, Institute Anatomy, Bochum, Germany.Laser-assisted PRK were performed rabbits studied 1, 3, 10, 20 days surgery. Excimer photoablation was done unilaterally with a 6.0 mm ablation zone an 80 microm depth, equivalent to -6.0 diopters. Keratocyte death analyzed using DNA fragmentation-detecting terminal...
To investigate newly designed, elliptical ELSA (excimer laser subepithelial ablation) instruments for the treatment of astigmatism.University Eye Clinic Regensburg, Germany, and Rayne Institute, Department Ophthalmology, St. Thomas' Hospital, London, United Kingdom.The new instrument set consists an microtrephine (11.0 mm x 8.0 mm) with a 70 microm calibrated blade alcohol cone (11.5 8.5 mm). With this set, (the laser-assisted keratectomy [LASEK] described by Camellin) was performed in 34...
Cases of endogenous bacterial endophthalmitis were analysed regarding predisposing factors, timing diagnosis, sources infection, causative organisms, and visual outcome. The value an immediate vitrectomy compared to exclusively injected intravitreal antibiotics was evaluated reviewing the literature.Records 22 consecutive cases last 9 years with reviewed. identified source infection treated systemic antibiotics. All affected eyes intraocular injection antibiotics, whenever possible combined...
For the purpose of visual rehabilitation subjects with photoreceptor degeneration, an implantable microelectronic device for epiretinal stimulation was developed. Our study aimed to show whether implantation and explantation could be conducted safely investigate tissue compatibility.The implanted in 5 Göttinger minipigs. Four weeks later, implant surgical- ly removed. Histopathological examination that followed at detecting inflammatory or proliferative changes. Stains used were hematoxylin...