A5086837864- Crime Patterns and Interventions
- Criminal Justice and Corrections Analysis
- Substance Abuse Treatment and Outcomes
- Crime, Illicit Activities, and Governance
- Social and Educational Sciences
- Child and Adolescent Psychosocial and Emotional Development
- Metabolism, Diabetes, and Cancer
- Bullying, Victimization, and Aggression
- Homelessness and Social Issues
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Sports, Gender, and Society
- Information and Cyber Security
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Cytomegalovirus and herpesvirus research
- Migration, Health and Trauma
- Emotions and Moral Behavior
- Behavioral Health and Interventions
- bioluminescence and chemiluminescence research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Adenosine and Purinergic Signaling
- Racial and Ethnic Identity Research
- Physical Education and Pedagogy
Malmö University
2015-2024
Linköping University
2022
Vrinnevisjukhuset i Norrköping
2020-2022
Salk Institute for Biological Studies
2012-2019
Linnaeus University
2019
University of Iowa
2008-2013
Howard Hughes Medical Institute
2012
Swedish Orphan Biovitrum (Sweden)
2011
Institute of Molecular Biology and Biophysics
2007
Stockholm University
2000-2004
Significance Liver kinase B1 (LKB1) is a serine/threonine often inactivated in human cancer. We demonstrate here that loss of LKB1 expression cancer cells promotes progrowth metabolic profile enables increased cell growth and proliferation. Loss tumor metabolism through mammalian target rapamycin complex 1- reactive oxygen species-dependent increases hypoxia-inducible factor-1α (HIF-1α). LKB1-null are dependent on HIF-1α to maintain cellular ATP viability under poor nutrient conditions,...
Abstract The stay-at-home restrictions to control the spread of COVID-19 led unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data on counts 27 cities across 23 countries Americas, Europe, Middle East and Asia. conducted interrupted time series analyses assess impact different types each city. Our findings show that policies were associated with a considerable drop crime, substantial variation crime. Meta-regression results...
This study investigates gender differences in adolescent drug use terms of parental monitoring and peer deviance. Females are found to be more highly monitored than males, whereas males exposed deviant peers females. There is a significant interaction between deviance for the sample as whole. The effect this greater among females, indicating that exposure important females families where poor.
In this paper we will test one of the key assumptions Situational Action Theory: that individuals’ (law-relevant) morality is more fundamental to their crime involvement than ability exercise self-control. We specifically hypothesize that, for individuals with a strong morality, capability self-control plays less role in it does weak whose may substantially influence engagement crime. To hypothesis use data from Peterborough Youth Study (PYS), cross-sectional survey 1957 adolescents aged...
Abstract Mutations in the LKB1 (also known as STK11) tumor suppressor are third most frequent genetic alteration non–small cell lung cancer (NSCLC). encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kinases (“AMPKRs”). The function of many AMPKRs remains obscure, which critical to tumor-suppressive unknown. Here, we combine CRISPR analysis AMPKR NSCLC lines mouse models, revealing surprising role for SIK subfamily. Conditional loss Sik1 revealed...
Abstract Background Previous research on the relationship between social media use and well-being in adolescents has yielded inconsistent results. We addressed this issue by examining association various digital activities, including a new differentiated measure of use, (internalizing symptoms) adolescent boys girls. Method The sample was drawn from four cross-sectional surveys Öckerö project (2016–2019) eight municipalities southern Sweden, consisting 3957 year 7 compulsory education, aged...
Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several organelle-specific pathways are available for provision of as nutrient availability fluctuates, so understanding how maintain homeostasis under such stresses is critically important. To this end, we applied
This study examines whether morality and self-control have an interactional effect on offending. Drawing from the situational action theory, authors hypothesize that has a more important offending for individuals with low levels of than high morality. To test this hypothesis, self-report data were used three independent samples young adolescents in Antwerp, Belgium ( N = 2,486); Halmstad, Sweden 1,003); South-Holland, Netherlands 1,978). The findings provide strong support hypothesis is...
In this study we examine whether feelings of anticipated shame and guilt when being caught for an offence mediate the relationship between parental monitoring, bonds with parents school, deviant peers, moral values offending. We use data from SPAN project, a that collected detailed information about offending, emotions socialization among 843 adolescents in The Hague, Netherlands. results show both have strong direct effect on also offending is substantially mediated by guilt. This clearly...
This study examines the effects on adolescent offending of lifestyle risk and individual propensity to offend. It is assumed that will have a more important effect for those individuals with high levels propensity, whereas low it risky not, or only marginally, influence their involvement in offending. The data are drawn from two different samples young adolescents Antwerp, Belgium ( N = 2,486), Halmstad, Sweden 1,003). provide strong support hypothesis dependent strength weakness indicating...
This study examines whether deterrence and morality interact in the explanation of adolescent offending. On basis Situational Action Theory, author hypothesizes that is more effective preventing offending among individuals with low levels than high morality. To test this hypothesis, self-report data are used from a sample young adolescents Halmstad, Sweden ( N = 891). The findings provide strong support for hypothesis effect (measured as perceived risk getting caught, is, “certainty”) on...
In this study we examine to what extent within-individual changes in parental monitoring, bonds with parents and school, rule-breaking peers can explain morality. We distinguish between three key dimensions of morality: moral values, anticipated shame, guilt. use data from the SPAN project, a two-wave panel among 616 adolescents (ages 12–19) secondary schools The Hague, Netherlands. Employing fixed-effects model, found that are significantly related These findings emphasize important role...
Journal Article Strategic Offences in the Criminal Career Context Get access Robert Svensson Search for other works by this author on: Oxford Academic Google Scholar The British of Criminology, Volume 42, Issue 2, 1 March 2002, Pages 395–411, https://doi.org/10.1093/bjc/42.2.395 Published: 01 2002
Most cross-national studies of crime and violence explore variation in levels without empirically addressing the causes these variations. Drawing upon theoretical framework situational action theory causation (e.g. Wikström 2006), this study we aim to test whether difference among young people England Sweden can be explained (fully or partly) by country differences people's propensities lifestyles their interaction. To achieve use data from English Peterborough Youth Study Swedish Eskilstuna...
There is a well-documented gender difference in offending, with evidence that boys, on average, are more involved crime than girls. Opinions differ, however, whether the causes of apply to girls and boys similarly.Our aim explore propensity Our research questions were (1) there differences between moral values self-control; (2) these attributes similarly correlated offending among boys; (3) any interaction effect morality self-control identical for boys.Data drawn from Malmö Individual...
We identify CRTC2 as a key mediator of LKB1-mutant non–small cell lung cancer.
Abstract This study examines the declining crime trend among Swedish adolescents between 1999 and 2017 using data from eight repeated cross‐sectional waves of a nationally representative school survey ( N = ca. 49,000). We examined to what extent changes in parental monitoring, bonds, attitudes toward crime, routine activities, binge drinking were related noticeable decline youth crime. Multilevel modeling was employed for analysis temporal trends. found strong empirical support our...
Prostate-specific deletion of Pten in mice has been reported to recapitulate histological progression human prostate cancer. To improve on this model, we introduced the conditional ROSA26 luciferase reporter allele monitor cancer via bioluminescence imaging and extensively backcrossed onto albino C57BL/6 genetic background address variability tumor kinetics enhance sensitivity. Bioluminescence signal increased rapidly Pten(p-/-) from 3 11 weeks, but was much slower 52 weeks. Changes were...