A5029816976- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Higher Education and Teaching Methods
- International Student and Expatriate Challenges
- Poxvirus research and outbreaks
- Multilingual Education and Policy
- Virus-based gene therapy research
- Circular RNAs in diseases
- Educational Technology and Pedagogy
- Mosquito-borne diseases and control
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Complement system in diseases
- Parental Involvement in Education
- Innovative Educational Techniques
- Viral gastroenteritis research and epidemiology
- Gender Studies in Language
- Bartonella species infections research
- Innovative Teaching Methods
- Educational Technology and Assessment
- Virology and Viral Diseases
- Education and Work Dynamics
- Viral Infections and Vectors
- Digital Media and Visual Art
Rutgers, The State University of New Jersey
2017-2024
Rutgers New Jersey Medical School
2019-2023
Hubei University
2021
Jinan University
2009-2019
Reitaku University
2016
Heilongjiang Bayi Agricultural University
2014
Jingdezhen Ceramic Institute
2007
Dongwha Pharm (South Korea)
2006
As the global elderly population grows, it is socioeconomically and medically critical to provide diverse effective means of mitigating impact aging on human health. Previous studies showed that adeno-associated virus (AAV) vector induced overexpression certain proteins, which can suppress or reverse effects in animal models. In our study, we sought determine whether high-capacity cytomegalovirus (CMV) be an safe gene delivery method for two such protective factors: telomerase transcriptase...
Abstract Varicella caused by the primary infection of varicella-zoster virus (VZV) exerts a considerable disease burden globally. Current varicella vaccines consisting live-attenuated vOka strain VZV are generally safe and effective. However, retains full neurovirulence can establish latency reactivate to cause herpes zoster in vaccine recipients, raising safety concerns. Here, we rationally design candidate, v7D. This replicates like wild-type MRC-5 fibroblasts human PBMCs, carrier for...
Human cytomegalovirus (HCMV) encodes multiple surface glycoprotein complexes to infect a variety of cell types. The HCMV Pentamer, composed gH, gL, UL128, UL130, and UL131A, enhances entry into epithelial, endothelial, myeloid cells by interacting with the receptor neuropilin 2 (NRP2). Despite critical nature this interaction, molecular determinants that govern NRP2 recognition remain unclear. Here, we describe cryo-EM structure bound Pentamer. high-affinity interaction between these...
Coronaviruses are important pathogens of humans and animals, vaccine developments against them imperative. Due to the ability induce broad prolonged protective immunity convenient administration routes, live attenuated vaccines (LAVs) promising arms for controlling deadly coronavirus infections. However, potential recombination events between field strains raise a safety concern LAVs. The porcine epidemic diarrhea virus (PEDV) remodeled TRS (RMT) mutant generated in this study replicated...
We present a robust approach for cellular detection, imaging, localization, and quantification of human viral encoded circular RNAs (circRNA) using amplified fluorescence in situ hybridization (ampFISH). In this procedure, pair hairpin probes bind next to each other at contiguous stretches sequence then undergo conformational reorganization which initiates target-dependent chain reaction (HCR) resulting deposition an fluorescent signal the site. By harnessing capabilities both ampFISH...
The pathogens including viruses, parasites and other microbes, are known to emerge evolve since thousands of the years ago. Viruses potent infectious agents causing numerous life-threatening diseases in human beings co-evolved with evolution.
Varicella-zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox and shingles. ORF7 an important virulence determinant of VZV in both human skin nerve tissues, however, its specific function involved molecular mechanism pathogenesis remain largely elusive. Previous yeast two-hybrid studies on intraviral protein-protein interaction network herpesviruses have revealed may interact with ORF53, which virtually unstudied but essential viral protein. The aim this study to...
ABSTRACT Viral vector vaccine represents one of the important research directions novel vaccines. vectors can efficiently deliver foreign genes and drive robust transgene expression in vivo . Generally, viral vaccines achieve high immunogenicity rapid response to a new pandemic. However, few types have been thoroughly evaluated for development, application is often limited by packaging capacity, immunogenicity, or pre-existing immunity. Cytomegalovirus (CMV) has regarded as promising because...
Abstract As the global elderly population grows, it is socioeconomically and medically critical to have diverse effective means of mitigating impact aging on human health. Previous studies showed that adenovirus-associated virus (AAV) vector induced overexpression certain proteins can suppress or reverse effects in animal models. Here, we sought determine whether high-capacity cytomegalovirus be an safe gene delivery method for two such-protective factors: telomerase transcriptase (TERT)...