A5041448738- Microbial Metabolism and Applications
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Phytochemistry and Bioactivity Studies
- Gut microbiota and health
- Biochemical and Structural Characterization
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Phytochemistry Medicinal Plant Applications
Boston Children's Hospital
2022
Lemuel Shattuck Hospital
2022
Harvard University
2022
Universidade de São Paulo
2017-2021
Clinics Hospital of Ribeirão Preto
2021
Universidade de Ribeirão Preto
2017-2020
Chromobacterium violaceum is an abundant component of the soil and water microbiota in tropical subtropical regions around world. For many years, it was mainly known as a producer violacein reporter for discovery quorum sensing molecules. However, C. has recently emerged important model environmental opportunistic pathogen. Its high virulence human infections mouse infection involves possession several predicted traits, including two type III secretion systems (T3SSs). In this article,...
Quorum sensing fundamentally alters the interaction of Vibrio cholerae with aquatic environments, environmental hosts, and human intestine. At high cell density, quorum-sensing regulator HapR represses not only expression cholera toxin co-regulated pilus, virulence factors essential in infection, but also synthesis polysaccharide (VPS) exopolysaccharide-based matrix required for abiotic biotic surface attachment. Here, we describe a feature V. quorum that shifts host-pathogen toward...
Outer membrane vesicles (OMVs) are lipid nanoparticles released by Gram-negative bacteria, which play multiple roles in bacterial physiology and adaptation to diverse environments. In this work, we demonstrate that OMVs the environmental pathogen Chromobacterium violaceum deliver antimicrobial compound violacein competitor mediating its toxicity vivo at a long distance. purified ultracentrifugation from wild-type strain, but not violacein-abrogated mutant ΔvioABCDE, contained inhibited...
Chromobacterium violaceum is an environmental Gram-negative bacterium that causes infections in humans. Treatment of C. difficult and little known about the mechanisms antibiotic resistance this bacterium. In work, we identified mutations MarR family transcription factor EmrR protein GyrA as key determinants quinolone violaceum, defined a repressor MFS-type efflux pump EmrCAB. Null deletion emrR caused increased to nalidixic acid, but not other quinolones or antibiotics different classes....