A5011292373- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Ubiquitin and proteasome pathways
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Genetics and Neurodevelopmental Disorders
- Biomedical Ethics and Regulation
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- CRISPR and Genetic Engineering
- Axon Guidance and Neuronal Signaling
- Mental Health Research Topics
- Nerve injury and regeneration
- Neural dynamics and brain function
- Histone Deacetylase Inhibitors Research
- Hypothalamic control of reproductive hormones
Yokohama City University
2011-2025
Shigakkan University
2022-2024
National Center for Geriatrics and Gerontology
2022-2024
Keio University
2007-2011
Bridgestone (Japan)
2009
Japan Society for the Promotion of Science
2007
Fbxo45 is an F-box protein that restricted to the nervous system. Unlike other proteins, was found not form SCF complex as a result of amino acid substitution in consensus sequence for Cul1 binding. Proteomics analysis revealed specifically associates with PAM (protein associated Myc), RING finger-type ubiquitin ligase. Mice deficient were generated and die soon after birth respiratory distress. Fbxo45(-)(/)(-) embryos show abnormal innervation diaphragm, impaired synapse formation at...
Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration motor function recovery after cortex cryoinjury mice training-dependent...
Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. Here, we show that social isolation disrupts molecular, cellular, developmental processes, leading to behavioral dysfunction. Neonatal prevented long-term potentiation experience-dependent synaptic trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)...
Significance Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, underlying cellular molecular mechanisms involved are largely unknown. In a rat model neonatal isolation, we examined dominance juveniles. We further investigated relationship between actin dynamics glutamate synaptic AMPA receptor delivery spines medial prefrontal cortex (mPFC) isolated animals. Here, report that isolation alters mPFC by...
Experience-dependent plasticity is limited in the adult brain, and its molecular cellular mechanisms are poorly understood. Removal of myelin-inhibiting signaling protein, Nogo receptor (NgR1), restores neural plasticity. Here we found that, NgR1-deficient mice, whisker experience-driven synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPAR) insertion barrel cortex, which normally complete by 2 weeks after birth, lasts into adulthood. In vivo live imaging two-photon...
Cognitive function can be affected by the estrous cycle. However, effect of cycle on synaptic functions is poorly understood. Here we show that in female rats, inhibitory-avoidance (IA) task (hippocampus-dependent contextual fear-learning task) drives GluA2-lacking Ca2+-permeable AMPA receptors (CP-AMPARs) into hippocampal CA3-CA1 synapses during all periods except proestrous period, when estrogen levels are high. In addition, IA failed to drive CP-AMPARs ovariectomized rats only was...
Patient-specific induced pluripotent stem cells (iPSCs) facilitate understanding of the etiology diseases, discovery new drugs and development novel therapeutic interventions. A frequently used starting source for generating iPSCs has been dermal fibroblasts (DFs) isolated from skin biopsies. However, there are also numerous repositories containing lymphoblastoid B-cell lines (LCLs) generated a variety patients. To date, this rich bioresource LCLs underused iPSCs, its use would greatly...
Old animals display significant alterations in sleep–wake patterns such as increases sleep fragmentation and propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons the dorsomedial hypothalamus (DMH) are activated during deprivation (SD) young mice but not old mice. Chemogenetic inhibition of Prdm13+ DMH promotes increase attempts SD, suggesting its involvement control. Furthermore, DMH-specific Prdm13 -knockout (DMH- -KO) recapitulated age-associated...
Many patients with Alzheimer's disease experience behavioral and psychological symptoms of dementia (BPSD), which significantly affect their quality life. It is known that 5-Hydroxytryptamine (5-HT) plays a crucial role in the development BPSD. However, relationship between tooth loss symptoms, particularly aggression, has remained unexplored. Although nutritional status to influence progression dementia, specific effect on peripheral notably not well understood. In our study, we conducted...
Neural stem cells (NSCs) proliferate and generate new neurons in the adult brain. A carbohydrate-binding protein (lectin), Galectin-1, is expressed NSCs subependymal zone (SEZ) of mouse The infusion knockout Galectin-1 SEZ results an increase decrease, respectively, subsequently born progenitor cells. molecular mechanism this effect, however, has been unknown. Previous studies outside brain suggest that binds to a carbohydrate structure beta1 Integrin modulates cell adhesion. Here, we...
Abstract Age-related tooth loss impedes mastication. Epidemiological and physiological studies have reported that poor oral hygiene occlusion are associated with cognitive decline. In the present study, we analyzed mechanism by which decreased occlusal support following bilateral extraction of maxillary first molars affects functions in young aged mice examined expression brain-function-related genes hippocampus hypothalamus. We observed working memory, enhanced restlessness, increased...
The relationship between caloric and nutrient intake overall health has been extensively studied. However, little research focused on the impact of hardness staple foods health. In this study, we investigated effects a soft diet brain function behavior in mice from an early age. Mice fed for six months exhibited increased body weight total cholesterol levels, along with impaired cognitive motor function, heightened nocturnal activity, aggression. Interestingly, when these were switched back...
Tooth loss and decreased masticatory function reportedly affect cognitive function; tooth allegedly induces astrogliosis aging of astrocytes in the hippocampus hypothalamus, which is a response specific to central nervous system owing homeostasis different brain regions. Capsaicin, component red peppers, has positive effects on disorders mice. Decreased expression transient receptor potential vanilloid 1, capsaicin, associated with development dementia. In this study, we investigated effect...
Sleep deprivation (SD) causes several adverse functional outcomes, and understanding the associated processes can improve quality of life. Although effects SD on neuronal activity in brain regions have been identified, a comprehensive evaluation whole is still lacking. Hence, we performed using two different methods, gentle handling dedicated chamber, targeted recombination active populations 2 (TRAP2) mice crossed with Rosa-ZsGreen reporter visualized cellular brain. Using semi-automated...
Abstract Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing factor, resulted reduced dynamics at spines an attenuation of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor delivery juvenile rat medial prefrontal cortex...
It has come to our attention that multiple gel images in Figure 1A were inappropriately duplicated from a previous