A5030112639- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Helminth infection and control
- Parasite Biology and Host Interactions
- Synthesis and Biological Evaluation
- Toxoplasma gondii Research Studies
- Cardiovascular Effects of Exercise
- Lysosomal Storage Disorders Research
- Biochemical and Molecular Research
- Science and Education Research
- Zoonotic diseases and public health
- Coronary Artery Anomalies
- Biotechnology and Related Fields
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
- RNA and protein synthesis mechanisms
- Poxvirus research and outbreaks
- T-cell and Retrovirus Studies
- Global Health and Epidemiology
- Studies on Chitinases and Chitosanases
- Parasitic Diseases Research and Treatment
- Cardiac Arrhythmias and Treatments
- Parasitic Infections and Diagnostics
International Olive Council
2024
Fundação Oswaldo Cruz
2006-2024
Escola Nacional de Saúde Pública
2008
Hospital Universitário Clementino Fraga Filho
1999
Universidade Federal do Rio de Janeiro
1999
Czech Academy of Sciences, Institute of Microbiology
1999
Universidade Federal do Piauí
1999
Fujirebio (Belgium)
1999
Universidade de São Paulo
1996
Immunoblotting with trypomastigote excreted-secreted antigens (TESA blot) of Trypanosoma cruzi was evaluated as a method for diagnosis chronic and acute phases well congenital (in newborn children) Chagas' disease. Serum samples from acute-phase infections were considered to be positive when they reacted ladder-like bands 130- 200-kDa antigens, recognized by immunoglobulin M (IgM) IgG antibodies, while chronic-phase sera broad band antigen 150 160 kDa. Nonchagasic not reactive these...
Artificial ecotopes of 121 peridomiciliary environments in four rural localities the state Ceará, Brazil, were studied and type material was identified as triatomine infestation. Two thousand two hundred Triatoma brasiliensis Neiva, 340 pseudomaculata Corrêa Espínola, Rhodnius nasutus Stall, 5 Panstrongylus lutzi (Neiva Pinto) captured. Out 323 found (X =2.0 ± 1.8 per dwelling) such pigpens, henhouses, corrals, perches, dovecotes, piles roofing tiles, bricks, wood, straw 30.3% infested by...
In order to assay the triatomine infestation and domiciliation in rural area of Jaguaruana district, state Ceará, Brazil, we studied, from November 2000 April 2002, 4 localities comprising 158 domiciles as a whole, with an average inhabitants/house, who are dwelling there for more than 7 years. Most houses have tile-covered roofs walls built plaster-covered bricks (57%), followed by without plaster (33%), mud (7.5%). A total 3082 triatomines were captured different locations, according...
ABSTRACT Chagas’ disease is a common cause of morbidity in Latin American countries. In Brazil, naturally occurring transmission its etiologic agent, Trypanosoma cruzi , has been almost completely abolished through effective control programs aimed at the triatomid insect vector. Thus, transfusion blood from infected donors become major route for contracting due to socioeconomically motivated migration residents areas where endemic larger urban centers. Therefore, employment screening tests...
INTRODUÇÃO: Foi realizado um estudo soroepidemiológico e clínico em 152 indivíduos residentes no município de Barcelos, Estado do Amazonas. Avaliou-se a soroprevalência da infecção chagásica morbidade doença Chagas. MÉTODOS: Os testes sorológicos foram imunofluorescência indireta, ELISA convencional recombinante o Tesa-blot. Foram considerados soropositivos 38 pacientes, duvidosos 31 soronegativos negativos 83. casos pareados com controles mesma idade, sexo submetidos à avaliação...
We developed a protein to rapidly and accurately diagnose Chagas disease, life-threatening illness identified by the WHO as critical worldwide public health risk. Complicating current situation are serological test limitations that contribute most infected persons being unaware of their condition therefore untreated. To improve diagnostic testing, we an immunological mimic etiological agent, Trypanosoma cruzi, combining ten pathogen specific epitopes within beta-barrel structure Thermal...
Com o objetivo de avaliar a situação epidemiológica da infecção chagásica no Estado do Piauí e sua relação com idade, gênero, transfusão sangue aborto espontâneo, foi realizado, agosto dezembro 2002, um inquérito sorológico exame uma amostra aleatória simples 36.399 moradores área rural. A definida pelo teste imunofluorescência indireta para anticorpos antiTrypanosoma cruzi em coletada papel filtro. soroprevalência total 1,9%, variando 0,1% menores 5 anos 6,6% maiores 79 anos;...
Um estudo transversal sobre a doença de Chagas realizado com o exame da população quatro localidades (nº= 541 habitantes) do município Jaguaruana, estado Ceará, mostrou: soroprevalência infecção chagásica em 3,1%, avaliada pelos testes imunofluorescência indireta, hemaglutinação indireta e ELISA, maior entre as pessoas mais 50 anos sem diferença relação ao sexo; parasitemia positiva 11,8% (2/17) soropositivos, determinada pelo xenodiagnóstico indireto 75% (9/12) pela reação cadeia polimerase...
With the aid of live-bait traps, we studied risk that Copernicia prunifera palm trees, present in both periurban and rural localities an endemic Brazilian northeast Chagas disease region, represent to domestic infestation by Rhodnius nasutus. In this area, important vector has been encountered harboring transmitting Trypanosoma cruzi, etiologic agent American trypanosomiasis, mammals, possibly including humans. Results indicate bug colonizes C. trees regions, mainly dry seasons, is infected...
In order to investigate aspects of the infection and morbidity Chagas' disease in municipality João Costa, Piauí State, Brazil, we carried out a serological survey detect anti-Trypanosoma cruzi antibodies 2,080 individuals, by indirect immunofluorescence, hemagglutination ELISA. A total 189 seropositive 141 seronegative patients were evaluated anamnesis, physical exam electrocardiogram (EKG). The parasitaemia 106 chagasic was xenodiagnosis PCR (polymerase chain reaction). seropositivity...
Chagas disease has been almost entirely eradicated from the arid zones in Central and Northeastern Brazil where rare or no autochthonous cases have reported. However, last 10 years increasingly registered Amazon Region. Aiming to investigate possibility of occurrence cycle Roraima, triatomine collections, vectorial susceptibility studies (this one be shown elsewhere), parasitological serological analyses were conducted three agricultural settlement areas (Rorainópolis, Passarão Project Ilha...
During thirty years - 1973-2003 a group of individuals infected by Schistosoma mansoni in Capitão Andrade, Rio Doce Valley, Minas Gerais, Brazil, was evaluated the same authors, being one longest follow-up studies on schistosomiasisis an endemic area. The diagnosis S. based parasitological stool tests. In clinical classification, three groups were considered: type I schistosomiasis-infection, II hepatointestinal form, and III- hepatosplenic form. prevalence infection 60.8% 1973, 36.2% 1984,...
BACKGROUND: The transfusion of contaminated blood has become the major route transmission for Chagas' disease in Brazil. Current screening tests are insensitive and yield conflicting results, while confirmatory assays do not exist. A line immunoassay (INNO‐LIA Chagas Ab [INNO‐LIA]) combining relevant, immunodominant recombinant synthetic antigens on a single nylon membrane strip was evaluated serologic confirmation disease. STUDY DESIGN AND METHODS: Sera from 1062 patients healthy residents...
Foram estudados 186 pares de indivíduos sorologicamente positivos e negativos para infecção chagásica, da mesma idade sexo, do Sertão Paraíba 200 também nos municípios Oeiras Colônia Piauí. Depois confirmados por pelo menos dois outros testes sorológicos: imunofluorescência indireta quantitativa, ELISA, hemaglutinação ou fixação complemento,foi feito o exame clínico, eletrocardiográfico radiológico selecionados estudo exenodiagnóstico, hemocultura PCR em amostras representativas dos casos...
Com o objetivo de avaliar aspectos epidemiológicos, clínicos e parasitológicos da doença Chagas crônica, em pacientes do Hospital Universitário Universidade Federal Mato Grosso Sul, realizamos um estudo seccional envolvendo 120 chagásicos controles não-chagásicos, ambos os sexos, com idades 16 a 82 anos. Os epidemiológicos foram avaliados por questionário, cardiopatia exame clínico, eletrocardiograma convencional, radiologia ecodopplercardiograma presença Trypanosoma cruzi no sangue...
We developed a protein to rapidly and accurately diagnose Chagas disease, life-threatening illness identified by the WHO as critical worldwide public health risk. Limitations in present day serological tests are complicating current situation contributing most infected persons being unaware of their condition therefore untreated. To improve diagnostic testing, we an immunological mimic etiological agent,
The study aimed at the evaluation of clinical and epidemiological characteristics aneurysm found in left ventricle chronic Chagas' disease patients. Three hundred, eighty eight people (298 chagasic patients 90 randomly selected healthy individuals) were submitted to echocardiography. ventricular function was assessed M mode by calculating fraction ejection, bidimensional analyzing he global systolic function. Segmental contractility evaluated according method described American Society...
Com o objetivo de avaliar alguns aspectos da doença Chagas na população urbana dos 12 municípios do distrito sanitário Rio Verde, Mato Grosso Sul, em 1998 realizamos a pesquisa IgG anti-T. cruzi pela imunofluorescência indireta amostras sangue obtidas papel filtro 14.709 moradores, com posterior confirmação pelos testes hemaglutinação e ELISA soros. A parasitemia foi avaliada por xenodiagnóstico indireto 134 chagásicos crônicos cardiopatia anamnese, exame físico eletrocardiograma (ECG) 191...
In order to investigate the relationship between T. cruzi specific antibodies (IgG) levels and clinical course of chronic chagasic cardiopathy, authors analyzed sera from 140 non-treated patients with drugs Virgem da Lapa, Minas Gerais, during 10 years. Of these patients, 92 were women 48 men, varying 70 years old (mean = 38 +/-13.5 years). Antibody estimated by mean titers obtained an indirect immunofluorescence test, hemagglutination assay reactivity indexes (OD/cut-off) ELISA tests using...