A5000776327- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- DNA and Nucleic Acid Chemistry
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Palliative Care and End-of-Life Issues
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Cell Adhesion Molecules Research
- Cancer survivorship and care
- Cancer Research and Treatments
- Chemical Reactions and Isotopes
- Metal complexes synthesis and properties
- Inflammatory mediators and NSAID effects
- DNA Repair Mechanisms
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Cancer therapeutics and mechanisms
Vaasa Central Hospital
2015-2025
University of Turku
2015-2025
Turku University Hospital
2000-2023
University of Helsinki
2000-2022
University of Vaasa
2014-2017
Vanha Vaasa hospital
2015
Finnish Dental Association
2015
Satakunta Central Hospital
2015
Helsinki University Hospital
1994-2010
Helsinki Institute of Physics
1996
Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice.A prospective Finnish nationwide study enrolled treatable metastatic CRC patients. The intervention was the assessment resectability upfront and twice during first-line therapy by multidisciplinary team (MDT) at Helsinki tertiary referral centre. primary outcome resection rates survival.In 2012-2018, 1086 patients were included. Median follow-up 58 months. Multiple sites...
AimThe aim of the study was to assess patient preference for fixed-dose combination pertuzumab and trastuzumab subcutaneous injection (PH FDC SC) in patients with HER2-positive early breast cancer PHranceSCa (NCT03674112).Materials methodsPatients who completed neoadjuvant P + H chemotherapy surgery were randomised 1:1 three intravenous (IV) cycles followed by PH SC or vice versa (crossover) then chose (SC) IV infusion continue up 18 (continuation). Assessments via healthcare professional...
Abstract Introduction As the global burden of chronic cancer increases, its correlation to lifestyle, socioeconomic status (SES) and health equity becomes more important. The aim present study was provide a snapshot lifestyle patterns for different types in patients at Nordic tertiary clinic. Materials methods In descriptive observational study, questionnaires addressed highest-attained educational level, occupational economy, relationship status, exposures, habits. questionnaire distributed...
Background and purpose: Health literacy is defined as the ability to find, understand use health information for informed decision. The role of in treatment decisions outcome remains largely unexplored. This study sought out assess effect individual on overall survival (OS) cancer patients Ostrobothnia. Material methods: present a follow-up cross-sectional survey performed during December 2021 March 2022. assessed socioeconomic factors, lifestyle factors self-reported literacy. included data...
Tumour angiogenesis is essential for tumour growth and metastasis. Several lines of evidence indicate that vascular endothelial factor (VEGF) a major regulator both physiological pathological angiogenesis. In this study we assessed the blood vessel density VEGF expression 94 melanoma metastases 70 patients by immunohistochemistry, utilizing antibodies against human platelet cell adhesion molecule-1 (PECAM-1, CD31) VEGF. The number vessels ranged from 4 to 131 vessels/high power field (HPF),...
Background: The Nordic countries are similar in terms of demographics and health care organization. Yet there marked differences lung cancer mortality, for which Denmark historically has had the poorest outcome. One several possible reasons these could have to do with how is diagnosed treated different countries. However, among four most populous countries: Sweden, Denmark, Norway Finland, a paucity knowledge about similarities recommendations national guidelines non-small cell (NSCLC)...
Several susceptibility genes have been established for female breast cancer, of which mutations in BRCA1 and especially BRCA2 are also known risk factors male cancer (MBC). The role other MBC is less well understood.In this study, we genotyped 68 patients the or ovarian associated Finnish population CHEK2, PALB2, RAD51C, RAD51D, FANCM genes.CHEK2 c.1100delC mutation was found 4 (5.9%), significantly more frequent than control (OR: 4.47, 95% CI 1.51-13.18, p = 0.019). Four CHEK2 I157T...
Study Design. A prospective, randomized double-blind comparative trial. Objectives. To evaluate the efficacy and tolerability of nimesulide, a cyclooxygenase (COX)-2–selective anti-inflammatory agent versus ibuprofen in patients with acute lumbosacral back pain. Summary Background Data. Nonsteroidal drugs (NSAIDs) have been more effective than placebo uncomplicated low pain previous controlled trials. The new COX-2–selective drug not yet established. Methods. One hundred four aged 18–65...
The genetic changes underlying the development of resistance to platinum-containing drugs are poorly defined. We analyzed six resistant cell lines using comparative genomic hybridization (CGH) in order screen and identify possible common. compared parental 2008 A2780 human ovarian cancer cells sublines selected for cisplatin (DDP) (2008/C8, 2008/C13*5.25, 2008/A, A2780/CP); we also antimonite (2008/H) arsenite (2008/I) which demonstrated cross-resistance DDP. DNA samples from were hybridized...
We have previously shown that forskolin and 3-isobutyl-1-methylxanthine (IBMX) increased accumulation of cisplatin (DDP) in DDP-sensitive 2008 human ovarian carcinoma cells proportion to their ability increase cAMP. Since the major function cAMP is activate protein kinase A, it was conjectured stimulation DDP mediated by a A substrate. now show exposure resulted phosphorylation prominent 52-kD membrane protein. Microsequencing band demonstrated be beta-tubulin. Similarly, pretreatment with...
Abstract Purpose: To determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics of tasidotin (ILX651), a dolastatin-15 analogue, when administered on days 1, 3, 5 every 3 weeks in patients with advanced solid tumors. Patients Methods: Thirty-two were treated 92 courses through seven levels determined by modified Fibonacci scheme ranging from 3.9 to 45.7 mg/m2. Pharmacokinetic samples collected during first course. Results: Neutropenia was principal DLT at...
Abstract Purpose: To determine the maximum tolerated dose, dose-limiting toxicity, and pharmacokinetics of dolastatin-15 analogue, tasidotin (ILX651), when administered i.v. daily for 5 days every 3 weeks. Experimental Design: Thirty-six patients with advanced solid tumors received a total 114 courses through eight dose levels ranging from 2.3 to 36.3 mg/m2. Pharmacokinetic samples were collected in cycle 1. Results: Neutropenia was principal toxicity at mg/m2/d along grade ileus elevated...
Abstract Background Prostate cancer is the most common among men, and its diagnosis treatment are improving. Our study evaluated how PSMA-PET/CT prior to planning might improve optimal management of prostate radiotherapy. Methods This retrospective pilot included 43 (PCa) patients referred our radiation oncologist department, from urology for therapy. 18F-PSMA-PET/CT was ordered by oncologists mainly due lack resent image staging. The were divided into three different groups according their...
Many attempts to define a good death have been recorded in the academic literature. In most of these attempts, methods used surveys, interviews, and focus groups. These yielded important information, but they failed provide an opportunity for public deliberation, whereby people engage collectively with issue, consider it from all sides, struggle understand it. We believe that well-orchestrated deliberation could contribute defining death. gathered data four deliberative forums implemented...
Two hundred thirty-seven patients with small cell lung cancer (SCLC), who had responded to induction chemotherapy and radiotherapy, were randomly assigned receive low-dose natural interferon-α (nIFNα) for 6 months; or cycles of maintenance (CAP); no therapy (control group). Although there was difference in median survival between the groups, a significant (p = 0.04) long-term limited disease, favour nIFNα therapy. This finding is now confirmed by further analysis most recent data. Ten...