A5074753560- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Particle Accelerators and Free-Electron Lasers
- Radiopharmaceutical Chemistry and Applications
- Particle accelerators and beam dynamics
- Radiation Dose and Imaging
- Ear and Head Tumors
- Management of metastatic bone disease
- Advanced MRI Techniques and Applications
- Radiation Effects and Dosimetry
- Nuclear Physics and Applications
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Multiple and Secondary Primary Cancers
- Molecular Communication and Nanonetworks
- Ocular Oncology and Treatments
- Boron Compounds in Chemistry
- Laser-induced spectroscopy and plasma
- Effects of Radiation Exposure
- Lung Cancer Diagnosis and Treatment
University of Southern California
2022-2024
USC Norris Comprehensive Cancer Center
2024
Keck Hospital of USC
2023-2024
University of California, Los Angeles
2015-2022
The Ohio State University Wexner Medical Center
2020
UCLA Health
2015-2016
RadiaBeam Technologies (United States)
2013-2015
Willis-Knighton Cancer Center
2015
Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation (IMRT), and volumetric-modulated arc (VMAT) represent the most advanced treatment methods based on heavy ion X-rays, respectively. Here we compare their performance for prostate cancer treatment. Ten patients were planned using IMPT with robustness optimization, VMAT, to an initial dose of 54 Gy a clinical target volume (CTV) that encompassed seminal vesicles, then boost prescription 25.2 total 79.2 Gy....
PurposeThe 4π static noncoplanar radiation therapy delivery technique has demonstrated better normal tissue sparing and dose conformity than the clinically used volumetric modulated arc (VMAT). It is unclear whether this a fundamental limitation of VMAT or coplanar nature its typical clinical plans. The dosimetry limits toxicity constrained escalation VMAT, are quantified in study.Methods materialsClinical stereotactic body plans for 20 liver patients receiving 30 to 60 Gy using (cVMAT) were...
It is useful to predict planned dosimetry and determine the eligibility of a liver cancer patient for SBRT treatment using knowledge based planning (KBP). We compare predictive accuracy overlap volume histogram (OVH) statistical voxel dose learning (SVDL) KBP prediction models coplanar VMAT non-coplanar 4π radiotherapy plans.In this study, 21 cases were selected, which initially treated plans. They then re-planned IMRT plans with 20 inversely optimized beams. OVH was calculated by expanding...
This study evaluates the potential for tumor dose escalation in recurrent head and neck cancer (rHNC) patients with automated non-coplanar volumetric modulated arc therapy (VMAT) stereotactic body radiation (SBRT) planning (HyperArc). Twenty rHNC are planned conventional VMAT SBRT to 40 Gy while minimizing organ-at-risk (OAR) doses. They then re-planned HyperArc technique match these minimal OAR doses escalating target as high possible. Then, we compare dosimetry, control probability (TCP),...
This study reports the initial results for first 15 patients on a prospective phase II clinical trial exploring safety, feasibility, and efficacy of HyperArc technique recurrent head neck cancer treatment. Eligible were simulated planned with both conventional VMAT techniques plan superior dosimetry was selected Dosimetry, delivery feasibility treatment-related toxicity, patient-reported quality life (QOL) all evaluated. chosen over enabled statistically significant increases in dose...
Purpose: To deliver high quality intensity modulated radiotherapy (IMRT) using a novel generalized sparse orthogonal collimators (SOCs), the authors introduce direct aperture optimization (DAO) approach based on discrete rectangular representation. Methods: A total of seven patients—two glioblastoma multiforme, three head & neck (including one with prescription doses), and two lung—were included. 20 noncoplanar beams were selected column generation pricing method. The SOC is conventional...
Purpose A dose‐modulation device for small animal radiotherapy is required to use clinically analogous treatment techniques, which will likely increase the translatability of preclinical research results. Because used multileaf collimator (MLC) impractical miniaturization, we have developed a simpler, better‐suited sparse orthogonal (SOC) delivering intensity‐modulated radiation therapy (IMRT) using rectangular aperture optimization (RAO) planning system. Methods The SOC system was modeled...
Abstract Purpose The purpose of this study is to characterize the dosimetric properties a commercial brass GRID collimator for high energy photon beams including 15 and 10 MV. Then, difference in parameters among different energies linacs was evaluated. Method A water tank scanning system used acquire parameters, percentage depth dose (PDD), beam profiles, peak valley ratios (PVDRs), output factors (OFs). profiles at various depths were measured 100 cm source surface distance (SSD), field...
Purpose: To investigate the feasibility of using intermediate energy 2 MV x‐rays for extracranial robotic intensity modulated radiation therapy. Methods: Two megavolts flattening filter free were simulated Monte Carlo code MCNP (v4c). A convolution/superposition dose calculation program was tuned to match calculation. The modeled and actual 6 flattened from existing Varian Linacs used in integrated beam orientation fluence optimization a head neck, liver, lung, partial breast treatment....
: High doses of radiation to the hippocampus have been correlated with increased cognitive decline following therapy for brain metastases. To mitigate these effects, a variety hippocampal sparing techniques implemented both whole (WBRT) and stereotactic radiosurgery (SRS). The goal this review article is provide practical resource clinical implementation hippocampal-sparing therapy, starting brief background on function delineation structure, as well effects most widely recommended dose...
Purpose To achieve more translatable preclinical research results, small animal irradiation needs to closely simulate human radiotherapy. Although the clinical gold standard is intensity‐modulated radiation therapy (IMRT), direct translation of this method for animals impractical. In study we describe treatment planning system a novel dose modulation device address challenge. Methods Using delineated target and avoidance structures, rectangular aperture optimization (RAO) problem was...
We present the design and demonstration of a unique novel detector for electron microscopy based on microelectromechanical systems (MEMS) technology. The is optimized transmission backscatter diffraction, or more specifically Kikuchi will allow this new analytic tool to realize its full potential. In addition, single capable simultaneous acquisition bright field dark images in scanning may replace number single-purpose detectors presently used these devices.
Purpose: To develop a robust and efficient platform for the optimization robotic delivery of highly noncoplanar intensity modulated radiotherapy, which enables significant reduction normal tissue toxicity escalation tumor dose. Methods: An innovative high‐output compact 3 MV linac was designed mounting onto commercial system in order to access entire 4π beam solution space without moving patient couch. The use intermediate energy X‐rays radiotherapy evaluated comparison clinical plans...
Surgical placement of eye plaque brachytherapy (EPB) is the standard care for treatment uveal melanomas, including iris/iridociliary melanomas. However, unique challenges exist in anterior EPB placement. Here, we describe a surgical technique when requires positioning onto cornea. Blunt conjunctival peritomy exposes sclera overlying tumor. A “dummy” placed, with confirmed by direct visualization. The amniotic membrane draped across cornea and anchored eyelet sutures, placed membrane,...