A5079752474- Immune Cell Function and Interaction
- Complement system in diseases
- Inflammation biomarkers and pathways
The University of Texas Southwestern Medical Center
2022-2023
Peristaltic movement of the intestine propels food down length gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and enteric nervous system regulate motility, yet we have an incomplete understanding molecular mediators this crosstalk. Here, identify complement component 1q (C1q) as a macrophage product that regulates gut motility. Macrophages were predominant source C1q in mouse most extraintestinal tissues. Although mediates...
ABSTRACT Peristaltic movement of the intestine propels food down length gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and enteric nervous system regulate motility, yet we have an incomplete understanding molecular mediators this crosstalk. Here identify complement component 1q (C1q) as a macrophage product that regulates gut motility. Macrophages were predominant source C1q in mouse most extraintestinal tissues. Although mediates...