A5052729820- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Digital Imaging for Blood Diseases
- Intraocular Surgery and Lenses
- Allergic Rhinitis and Sensitization
- Hormonal Regulation and Hypertension
- Dye analysis and toxicity
- Cardiovascular Health and Disease Prevention
- Olfactory and Sensory Function Studies
- Textile materials and evaluations
- Ocular Infections and Treatments
- Apelin-related biomedical research
- Thermoregulation and physiological responses
- Blood Pressure and Hypertension Studies
- Color perception and design
- Ergonomics and Musculoskeletal Disorders
Cardiff University
2016-2025
Retinal and intra-retinal layer thicknesses are routinely generated from optical coherence tomography (OCT) images, but on-board software capabilities image scaling assumptions not consistent across devices. This study evaluates the device-independent Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) automated segmentation three OCT systems. Healthy participants (n = 25) underwent macular volume scans using a Cirrus HD-OCT (Zeiss), 3D-OCT 1000 (Topcon), non-commercial...
Purpose: Choroidal thickness (ChT) and choroidal vascularity index (CVI) represent two important metrics in health-, disease-, myopia-related studies. Wide-field swept-source optical coherence tomography (OCT) provides improved extended imaging extraction of variables. This study characterizes the topography repeatability these parameters healthy eyes. Methods: Swept-source OCT volume scans were obtained on 14 young adult patients three separate days. ChT CVI automatically corrected for...
Backgrounds/Objectives: The aim of this study was to compare differences in the physical characteristics lissamine green (LG) strips and outcomes using different staining techniques. Methods: Two separate complementary investigations were conducted. Physical study: Differences between four LG evaluated terms material, dye concentration, absorption. In vivo Bulbar conjunctival compared for application methods I-DEW presented a randomized order twenty-two participants: (1) single 5 s after...
SIGNIFICANCE When using lissamine green for bulbar conjunctival evaluation, the most staining was observed with two applications of same strip in eye, wetted a drop saline. The first application 5 seconds after wetting strip, and second 1 minute later, followed by immediate viewing. This suggests that should be viewed before lid wiper region. PURPOSE study aimed to optimize assessment conjunctiva investigating technique subsequent observation period. METHODS Twenty-two participants dry eye...
Purpose: To evaluate Pegasus optical coherence tomography (OCT), a clinical decision support software for the identification of features retinal disease from macula OCT scans, across heterogenous populations involving varying patient demographics, device manufacturers, acquisition sites, and operators. Methods: Five thousand five hundred eighty-eight normal anomalous macular volumes (162,721 B-scans), acquired at independent centers in countries, were processed using software. Results...
Refractive errors are associated with a range of pathological conditions, such as myopic maculopathy and glaucoma, highly heritable. Studies missense putative loss function (pLOF) variants identified via whole exome sequencing (WES) offer the prospect directly implicating potentially causative disease genes. We performed genome-wide association study for refractive error in 51 624 unrelated adults, European ancestry, aged 40-69 years from UK genotyped using WES. After testing 29 179 pLOF 495...
Objectives: To investigate the performance of a novel flat pack toric daily disposable contact lens compared with traditionally packaged lenses in randomized, crossover study. Environmental attitudes to wear were also explored. Methods: Habitual wearers recruited hioxifilcon A (Miru 1 day Flat Pack Toric, Menicon, Nagoya, Japan) test and control lens: either nelfilcon (Dailies AquaComfort Plus, Alcon, Geneva, Switzerland) or etafilcon (1-Day Acuvue Moist, Johnson & Johnson, New...
In this paper, we propose a two-step textural feature extraction method, which utilizes the learning ability of Convolutional Neural Networks (CNN) to extract set low level primitive filter kernels, and then generalizes discriminative power by forming histogram based descriptor. The proposed method is applied practical medical diagnosis problem classifying different stages Age-Related Macular Degeneration (AMD) using dataset comprising long-wavelength Optical Coherence Tomography (OCT)...
Purpose: Emmetropization requires coordinated scaling of the major ocular components, corneal curvature and axial length. This coordination is achieved in part through a shared set genetic variants that regulate eye size. Poorly length results refractive error. We tested hypothesis regulating size emmetropic eyes are distinct from those conferring susceptibility to Methods: A genome-wide association study (GWAS) for 22,180 adult individuals was performed as proxy GWAS polygenic score created...
Purpose: To evaluate the performance of Pegasus-OCT (Visulytix Ltd) multiclass automated fluid segmentation algorithms on independent spectral domain optical coherence tomography data sets. Methods: The Pegasus were applied to three sets with edematous pathology, comprising 750, 600, and 110 b-scans, respectively. Intraretinal (IRF), sub-retinal (SRF), pigment epithelial detachment (PED) automatically segmented by for each b-scan where ground truth from set owners was available. Detection...
The ovarian hormones, oestrogen and progesterone, have vaso- neuroprotective effects, likely due to interactions with the cerebrovascular system. This study investigates their neuroendocrine influence on a range of cerebral retinal vascular functions across healthy menstrual cycle. Twenty-six healthy, menstruating females completed imaging sessions assessment circulating hormone levels during early follicular, late mid-luteal phase (1-4, 10-12 20-22 days after menses onset). Cerebral blood...
<h3>Introduction</h3> Oestrogen has a protective effect against neurodegenerative conditions, including glaucoma and dementia. Animal models suggest that oestrogen vasodilatory effect, which is possible mechanism for this. However, the full influence of on specific cerebrovascular functions unclear. <h3>Aims</h3> This study aims to investigate hormonal fluctuations across healthy menstrual cycle measures retinal cortical vascular functioning. <h3>Methods</h3> 27 menstruating participants...