Combining a sequential, one-pot RAFT polymerization with the polymerization-induced self-assembly process results in versatile oxidation-responsive carrier system.

Upon extending a hydrophobic polymer chain from the end of preceding hydrophilic in aqueous solutions, resultant block copolymers may eventually undergo self-assembly.

Reactive polymersomes represent a versatile artificial cargo carrier system that can facilitate an immediate release in response to specific stimulus. The herein presented oxidation-sensitive feature time-delayed mechanism oxidative environment, which be precisely adjusted by either tuning the membrane thickness or partial pre-oxidation. These polymeric vesicles are conveniently prepared PISA allowing straightforward and effective situ encapsulation of molecules, as shown for dyes enzymes....

This study investigates the correlation between photocytotoxicity and prolonged excited-state lifetimes exhibited by certain Ru(II) polypyridyl photosensitizers comprised of π-expansive ligands. The eight metal complexes selected for this differ markedly in their triplet state configurations lifetimes. Human melanoma SKMEL28 human leukemia HL60 cells were used as vitro models to test induced compounds when activated either broadband visible or monochromatic red light. photocytotoxicities...

Responsive polymers, which become protonated at decreasing pH, are considered a milestone in the development of synthetic cell entry vectors. Exact correlations between their properties and ability to escape endosome, however, often remain elusive due hydrophobic interactions or limitations design water-soluble materials with suitable basicity. Here, we present series well-defined, hydrophilic polypiperazines, where systematic variation amino moiety facilitates an unprecedented fine-tuning...

Adaptation of solution morphologies for the same block copolymer by variation conditions during aqueous RAFT dispersion polymerization <italic>N</italic>-acryloylthiomorpholine.

Abstract We report a switchable, templated polymerization system where the strength of templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through dendritic polyamidoamine‐based template which charge density depends on pH. dendrimers act as for an oppositely charged monomer, namely sodium styrene sulfonate. show that rate and maximum achievable monomer conversion are directly related template, hence environmental could...

Inflammatory bowel disease (IBD) has become a globally prevalent chronic with no causal therapeutic options. Targeted drug delivery systems selectivity for inflamed areas in the gastrointestinal tract promise to reduce severe drug-related side effects. By creating three distinct nanostructures (vesicles, spherical, and wormlike micelles) from same amphiphilic block copolymer poly(butyl acrylate)-block-poly(ethylene oxide) (PBA-b-PEO), effect of nanoparticle shape on human mucosal penetration...

Polymer–metal hybrids are interesting materials in general and serve as precursors for a wide range of possible applications. Herein, we present the controlled radical polymerization 2-acrylamidoglycolic acid (AGA), polyelectrolyte capable chelating various metals, using reversible addition–fragmentation chain transfer (RAFT) polymerization. Polymerization kinetics behavior aqueous solution were investigated PAGA homopolymers, further show that double hydrophilic...

Block copolymer micelles have received increasing attention in the last decades, particular for their appealing properties nanomedicine. However, systematic investigations of interaction between polymeric and immune cells are still rare. Therefore, broader studies comparing structural effects remain inevitable a comprehensive understanding response design efficient, nonimmunogenic delivery systems. Here, we present novel block with same hydrophobic core, based on BA VDM, various hydrophilic...

Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas the gastrointestinal tract and circulating immune cells, providing novel opportunities for targeted drug delivery. In recent experiments, oxidation-responsive polymeric nanostructures selectively degrade presence H2 O2 . Based on these results, it hypothesized that such degradation process can be triggered a similar way incubation with stimulated monocytes isolated from...

Despite their promising potential in gene transfection, the toxicity and limited efficiency of cationic polymers as nonviral vectors are major obstacles for broader application. The large amount charges, example, poly(ethylene imine) (PEI) is known to be advantageous terms transfection but goes hand-in-hand with a high toxicity. Consequently, an efficient shielding charges required minimize toxic effects. In this study, we use simple mixed-micelle approach optimize charge density DNA complex...

Polymeric micelles with a hydrophobic core represent versatile nanostructures for encapsulation and delivery of water-insoluble drugs. Here, beclometasone dipropionate (BDP) which is potent anti-inflammatory therapeutic agent but limited to topical applications so far, encapsulated. Therefore, this work used an amphiphilic block copolymer self-assembling into flexible polymeric filomicelles, have recently proven selectively target inflamed areas in patients inflammatory bowel disease (IBD)....

Depending on the conditions, nearly monodisperse spherical micelles or complex morphologies are formed during a polymerization induced self-assembly (PISA) process based water-soluble monomer <italic>N</italic>-acryloylthiomorpholine.

Cationic pH-responsive polymers promise to overcome critical challenges in cellular delivery. Ideally, the become selectively charged along endosomal pathway disturbing only local membrane and avoiding unintended interactions or cytotoxic side effects at physiological conditions. Polypiperazines represent a novel, hydrophilic class of whose response can be tuned within relevant pH range (5-7.4). The authors discovered that polypiperazines are effectively binding plasmid DNA (pDNA)...

Front Cover: Polypiperazines are hydrophilic pH-sensitive polymers reaching high transfection efficiency and guaranteeing good biocompatibility. They almost charge-neutral under physiological conditions avoiding unintended side effects, while the isopropyl-modified polypiperazine outperforms commercial linear PEI at low N/P ratios. qPCR revealed that pDNA can still be amplified complexed with piperazine-based polymers, providing a promising platform for effective polymeric gene delivery...

Synthesis of well-defined poly(urea)-poly(2-ethyl-2-oxazoline) gradient copolymers.

Smart nano-carriers such as micelles, vesicles or nanoparticles constructed from amphiphilic polymers promise a new generation of drug delivery systems featuring localized and controlled release.

Wormlike Polymer Micelles In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co-workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa without affecting healthy tissue. Entering the lamina propria, further passively target only immune cells of biopsy, which is key for effective treatment IBD elimination drug-related side effects.

Abstract We report a switchable, templated polymerization system where the strength of templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through dendritic polyamidoamine‐based template which charge density depends on pH. dendrimers act as for an oppositely charged monomer, namely sodium styrene sulfonate. show that rate and maximum achievable monomer conversion are directly related template, hence environmental could...

Abstract Over the 21st century, inflammatory bowel disease (IBD) has become a global with no causal therapeutic options. Selective targeting of inflamed areas in gastrointestinal tract could be an effective treatment circumventing severe side effects for healthy tissue. Our study demonstrates that shape polymeric nanostructures represents so far rarely addressed key to required tissue selectivity intestine. Ex vivo experiments on human colonic biopsies revealed crosslinked wormlike micelles...

Inside Front Cover: In article number 2100482, Johannes C. Brendel, Andreas Stallmach, and co-workers describe the selective degradation of oxidation sensitive polymer micelles loaded with Nile red as sensor compound in primary human monocytes isolated from patients inflammatory bowel disease (IBD). No additional stimulation is required to induce a sufficient release reactive oxygen species which results comparison healthy donors.

Schaltbare templatierte Polymerisationen werden von Bas G. P. van Ravensteijn, Ilja K. Voets et al. in ihrem Forschungsartikel vorgestellt (e202206780). Die grünen und grauen Abschnitte im Titelbild stellen die hohen (grün) niedrigen (grau) pH-Bedingungen dar, unter denen das Templat aus- bzw. eingeschaltet ist. Im AUS-Zustand Monomere wachsende Polymere nicht vom angezogen, was eine Monomerumwandlung verhindert. EIN-Zustand wodurch ihre Polymerisation erleichtert wird. entstehenden Template...