A5063939653- Surfactants and Colloidal Systems
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Electrostatics and Colloid Interactions
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Spectroscopy and Quantum Chemical Studies
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Molecular Sensors and Ion Detection
- Porphyrin and Phthalocyanine Chemistry
- Field-Flow Fractionation Techniques
- Natural Compound Pharmacology Studies
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Material Dynamics and Properties
- Occupational exposure and asthma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related Molecular Pathways
- Graphene and Nanomaterials Applications
- Surface Modification and Superhydrophobicity
University of Massachusetts Amherst
2015-2025
Kobe University
2025
The University of Kitakyushu
2014-2024
Setsunan University
2024
Fukuoka University
2018-2020
Meijo University
2020
The University of Tokyo
1998-2019
Sojo University
2017
Kyushu University
2013-2015
Graduate School USA
2015
Manipulating phase separation structures of thermoresponsive polymers will enhance the usefulness structure-controllable materials in fields such as drug delivery and tissue engineering. However, behaviors upper critical solution temperature (UCST) have been less investigated so far, despite importance UCST. Here, we examined two citrulline-based polypeptides, poly(d-ornithine-co-d-citrulline) (PdOC) poly(dl-ornithine-co-dl-citrulline) (PdlOC), to investigate how stereoregularity...
Upon extending a hydrophobic polymer chain from the end of preceding hydrophilic in aqueous solutions, resultant block copolymers may eventually undergo self-assembly.
Biocompatible polymers possessing antifouling properties for biomolecules are necessary to be combined with nanoparticles cancer chemotherapy improve their retention in blood and subsequent tumor accumulation. However, these simultaneously lead poor affinity cells, low tissue permeability subsequently, which is one of the major barriers achieving efficient anticancer efficacy. To address this, we try elucidate using molecular bottlebrushes (MBs) as model polymeric composed various...
Abstract The concept of micelles was first proposed in 1913 by McBain and has rationalized numerous experimental results the self-aggregation surfactants. It is generally agreed that aggregation number ( N agg ) for spherical no exact value a certain distribution. However, our studies calix[4]arene surfactants showed they were monodisperse with defined whose values are chosen from 6, 8, 12, 20, 32. Interestingly, some these numbers coincide face Platonic solids, thus we named them “Platonic...
Cancer vaccine has the ability to directly eradicate tumor cells by creating and activating cytotoxic T lymphocytes (CTLs). To achieve efficient CTL activity induce Th1 responses, it is essential administer an appropriate adjuvant as well antigen. CpG-ODN known a ligand of Toll-like receptor 9 (TLR9) strongly induces responses. In our previous study, we developed delivery system use formation complexes between ODN β-glucan SPG, denoted CpG/SPG, demonstrated that CpG/SPG high this created...
Nanostructures of drug carriers play a crucial role in nanomedicine due to their ability influence delivery. There is yet no clear consensus regarding the optimal size and shape (e.g., aspect ratio) nanoparticles for minimizing macrophage uptake, given difficulties controlling while maintaining identical surface properties. Here, we employed graft copolymer self-assembly prepare polymer micelles with ratios ranging from 1.0 (spherical) 10.8 (cylindrical) closely matched interfacial Notably,...
A series of cationic calix[4]arene-based lipids with alkyl chains varying length were newly synthesized, and the ones propyl hexyl tails, denoted by CaL[4]C3 C6, respectively, found to form spherical micelles at low pH (protonated state amine headgroup). Upon deprotonation increasing pH, showed a sphere-to-cylinder transition, while CaL[4]C6 changed from sphere, cylinder, monolayer vesicle. Synchrotron small-angle X-ray scattering (SAXS) patterns both cylindrical exhibited sharp intensity...
An amphiphilic polymer bearing glutamic acid in the side chain was used as a surface modifier to produce an amino acid-based zwitterionic with pH-responsive and selective protein properties.
In cancer chemotherapy, core-cross-linked particles (CCPs) are a promising drug carrier due to their high structural stability in an vivo environment, resulting improved tumor delivery. A biocompatible polymer of polyethylene glycol (PEG) is often utilized coat the surface CCPs avoid nonspecific adsorption proteins vivo. The PEG density and conformation on particle important factors that determine fate such PEGylated nanoparticles, including pharmacokinetics pharmacodynamics. However,...
Abstract Background Some organic chemicals are known to cause allergic disorders such as bronchial asthma and hypersensitivity pneumonitis, it has been considered that they do not irreversible pulmonary fibrosis. It recently reported, however, cross-linked acrylic acid-based polymer, an chemical, might serious interstitial lung diseases, including We investigated whether or intratracheal instillation exposure polyacrylic acid (CL-PAA) can disorder in rats. Methods Male F344 rats were...
Artificially designed short single-stranded DNA sequences containing unmethylated CG (CpG ODNs) are agonists for toll-like receptor 9 (TLR9); thus, they have great potential as vaccine adjuvants cancer immunotherapy and preventing infectious diseases. To deliver effectively CpG ODNs into cells bearing TLR9, nanoparticle polyion complexes of cationic polymers that able to ingest multiple ODN molecules been developed; however, their structures synthesized polycations hard control...
We synthesized new calix[4]arene-based lipids, denoted by CPCaLn, bearing the choline phosphate (CP) group which is an inverse phosphoryl (PC) structure. Small-angle X-ray scattering and multi-angle light coupled with field flow fractionation showed that these lipids form monodisperse micelles a fixed aggregation number diameters of 1.9 2.6 nm for C3 C6 alkyl tails, respectively. Furthermore, when CPCaLn was mixed fluorescein isothiocyanate (FITC)-bearing added to cells, strong fluorescence...
Controlling the particle structure of tumor-targeting nanomedicines in vivo remains challenging but must be achieved to control their fate and functions. Molecular bottlebrushes (MBs), where brush side chains are densely grafted from a main chain, have recently received attention as building blocks polymer-based prodrugs because rigid would expected demonstrate high structural stability vivo. Here, we synthesized poly(methacryloyloxyethyl phosphorylcholine) (pMPC)-grafted molecular...
We report that the polymerization of cyclodextrin (CD) with epichlorohydrin (ECH) dramatically increases binding constant CD to vanillin, from 55 8.4 × 103 M-1, by approximately 100 times, as determined diffusion ordered spectroscopy (DOSY)-1H NMR. The increased an increase ECH content polymer, although polymers without CDs showed no affinity at all, suggesting hydrophobicity network outside helps enhance binding. This allows CD-ECH drug loading ratio, which may be one most critical issues...
Zwitterionic amino acid polymers (ZAPs) exhibit biocompatibility and recognition capability for transporters (AATs) overexpressed on cancer cells. They are potential cancer-targeting ligands in nanoparticle-based nanomedicines utilized chemotherapy. Here, a poly(glutamine methacrylate) (pGlnMA)-grafted core-crosslinked particle (pGlnMA-CCP) is prepared through the formation of nanoemulsions stabilized using amphiphilic block copolymers comprising pGlnMA as hydrophilic block. The chain...
A novel calix[4]arene amphiphilic molecule, denoted by CCaL3, was synthesized and found to form a spherical micelle consisting of 12 molecules at low pH in aqueous solution. Furthermore, uniform Au nanoparticles with 2.0 nm diameter were solution on the template four cysteines upper rim CCaL3. Asymmetric field flow fractionation coupled light scattering showed that there no dispersity CCaL3 micellar aggregation number. When AuCl4– ions added into solution, induced circular dichroism (ICD)...
The aggregation number of classical micelles exhibits a certain distribution, which is recognizable feature conventional micelles. However, we recently identified perfectly monodisperse calix[4]arene-based whose numbers agree with the vertex regular polyhedra, that is, Platonic solids, and thus they are named "Platonic micelles". Regarding our hypothesis formation mechanism micelles, both repulsive interactions including steric hindrance electrostatic repulsions among headgroups important...
A new cationic-lipid/siRNA particle that was designed to deliver siRNA investigated by the combination of small-angle X-ray scattering (SAXS), asymmetric field flow fractionation coupled with multiangle light scattering, and cryotransmission electron microscopy (cryo-TEM). The prepared through two-step mixing using a microfluidic technique. In first step, premixed cationic lipid in an EtOH-rich solution. second solution mixed other lipids, followed solvent exchange water. SAXS showed...
We conducted intratracheal instillations of polyacrylic acid (PAA) with crosslinking and non-crosslinking into rats in order to examine what kinds physicochemical characteristics acrylic-acid-based polymers affect responses the lung. F344 were intratracheally exposed similar molecular weights crosslinked PAA (CL-PAA) (degree crosslinking: ~0.1%) non-crosslinked (Non-CL-PAA) at low high doses. Rats sacrificed 3 days, 1 week, month, months, 6 months post-exposure. Both PAAs caused increases...