A5091344592- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Peripheral Nerve Disorders
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- RNA Interference and Gene Delivery
- Orthopedic Infections and Treatments
- Diagnosis and Treatment of Venous Diseases
- Neuroscience and Neural Engineering
- Vascular anomalies and interventions
- Musculoskeletal Disorders and Rehabilitation
- Intraocular Surgery and Lenses
- Anesthesia and Sedative Agents
- Gout, Hyperuricemia, Uric Acid
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Nerve Injury and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
Osaka Metropolitan University
2023-2024
Osaka Ekisaikai Hospital
2022-2023
The University of Kitakyushu
2023
Creative Commons
2023
Osaka City University
2021
Osaka Hospital
2019-2021
Osaka Seikei University
2019
Saiseikai Kumamoto Hospital
2019
Abstract Peripheral nerve regeneration using conduits has been less effective than autogenous grafts. To overcome this hurdle, we developed a tissue-engineered conduit coated with mouse induced pluripotent stem cell (iPSC)-derived neurospheres, for the first time, which accelerated in mice. We previously demonstrated long-term efficacy and safety outcomes of hybrid peripheral regeneration. In study, investigated therapeutic potential human iPSC (hiPSC)-derived neurospheres rat sciatic...
Artificially designed short single-stranded DNA sequences containing unmethylated CG (CpG ODNs) are agonists for toll-like receptor 9 (TLR9); thus, they have great potential as vaccine adjuvants cancer immunotherapy and preventing infectious diseases. To deliver effectively CpG ODNs into cells bearing TLR9, nanoparticle polyion complexes of cationic polymers that able to ingest multiple ODN molecules been developed; however, their structures synthesized polycations hard control...
Postprocedural peroneal nerve palsy after endovenous laser ablation (EVLA) for varicose veins is rare and associated with poor functional recovery. There have been no reports using tibial transfer iatrogenic EVLA. Herein, we present a case injury EVLA, which was successfully treated by partial the first time. A 75-year-old female presented right foot drop immediately EVLA of lesser saphenous vein. The ankle toe dorsiflexion had muscle grade M0 on British Medical Research Council scale,...
Romosozumab is a humanized, anti-sclerostin monoclonal antibody used to treat osteoporosis, which increases bone formation and decreases resorption. It enhances fracture healing systemic romosozumab administration may have therapeutic potentials for accelerating of even nonunion. Herein, 61-year-old heavy smoker male with distal radius nonunion who achieved successful union by combination therapy spanning distraction plate fixation graft substitutes was presented. Through the dorsal...
Since the advent of induced pluripotent stem cells (iPSCs), clinical trials using iPSC-based cell transplantation therapy have been performed in various fields regenerative medicine. We previously demonstrated that mouse iPSC-derived neurospheres containing neural stem/progenitor with bioabsorbable nerve conduits promoted regeneration long term murine sciatic defect models. However, it remains unclear how grafted survived and worked after implantation. In this study, long-term survival...
Abstract Triggering due to de Quervain's disease is exceedingly rare. This the first successfully diagnosed case of snapping phenomenon extensor pollicis brevis (EPB) tendon in evaluated with preoperative dynamic ultrasonography, clearly demonstrated an intraoperative video, and treated decompression EPB subcompartment only under a wide‐awake surgery. Dynamic ultrasonographic images identified caused by unsmooth excursion enlarged separate subcompartment. In disease, evaluations surgery are...
Flexor tendon rupture in the wrist of patients with rheumatoid arthritis is a rare complication, and there no standard treatment for joint. Here, we present case flexor digitorum profundus left index finger owing to wrist. Plain radiography computed tomography showed carpal collapse, especially lunate, arthrosis between capitate lunate. For stability mobility finger, resection lunate radiotriquetral (RT) arthrodesis using distal ulna as bone graft interphalangeal joint were performed. At 2...
Persistent median artery thrombosis mimicking carpal tunnel syndrome is rare. Here, we report the pathological, ultrasonography, and intraoperative findings of a case persistent syndrome. A 34-year-old man reported to our clinic with complaint numbness in his left thumb, index finger, middle which are innervated by nerve. He also that he felt pain wrist distal forearm while working. Although usual provocative tests nerve conduction studies were normal, ultrasonography revealed arterial at...
BACKGROUND: We previously demonstrated that a bioabsorbable nerve conduit coated with mouse induced pluripotent stem cell (iPSC)-derived neurospheres accelerated peripheral regeneration in mice. OBJECTIVE: examined the fate and utility of iPSC-derived transplanted conduits for treatment sciatic gaps METHODS: Complete 5-mm defects were created nerves reconstructed using either uncoated or neurospheres. The survival on was tracked an vivo imaging. localization cells regenerating axons...
Abstract Background While some traumatic closed index extensor tendon ruptures at the musclotendinous junction have been previously reported, pseudorupture due to intertendinous attenuation is exceedingly rare with only one case report of a gymnastics-related sports injury in English literature. Herein, we two non-sports related cases mimicking rupture, including pathological findings and intraoperative video attenuated indicis proprius tendon. Case presentation A 28-year-old man 30-year-old...
Effective treatment and rehabilitation of complex hand injuries are often challenging. Various corrective techniques approaches have been proposed for the first web space contractures based on a classification system, however, consensus regarding optimal management does not exist. In this study, we evaluated twelve consecutive patients with mean age 46.72 years who underwent dilatation using Ilizarov mini fixator from 2009 to 2020. The tip length during radial/palmar abduction angles were...