Background Osteonecrosis of the femoral head (ONFH) is one major side effects corticosteroid therapy. Because corticosteroids are metabolized by hepatic cytochrome P450 (CYP) 3A, a low endogenous activity this enzyme may contribute to pathogenesis ONFH. The purpose study was examine possible association CYP3A and susceptibility ONFH in patients treated with corticosteroids. Methods In prospective controlled we measured clearance intravenous midazolam (0.25 mg/kg) estimate steroid-induced (n...

Abstract Low hepatic cytochrome P4503A (CYP3A) activities might play an important role for inducing osteonecrosis of the femoral head (ONFH) by corticosteroids. However, relationship between CYP3A activity and steroid‐induced ONFH is unknown. We have examined inducibility in a rabbit model. Sixty rabbits were divided into three groups. Hepatic inducer (phenobarbital, group P; n = 15), inhibitor (itraconazole, I; or saline (group C, 30) was administrated 3 weeks before intramuscular...

Background: Multiple treatment protocols have been described in literature for the of terrible triad injury (TTI) elbow. We believe that repair medial collateral ligament (MCL) should be performed preference to a small coronoid fracture if elbow is unstable after fixation/replacement radial head and lateral (LCL). The aim this study report outcomes surgical patients with TTI associated whom was not addressed. Methods: This retrospective case series 12 consecutive who underwent surgery acute...

A chronic traumatic hyperextension of the proximal interphalangeal (PIP) joint can result from volar plate (VP) disruption. For treatment this disorder, reconstruction procedures have been traditionally recommended, because condition VP was not considered susceptible to repair due retraction or attenuation. The purpose paper is present operative technique and report clinical results late repair. Late performed for chronic, post-traumatic deformity PIP little finger resulting disruption in...

Juxta-articular myxoma (JAM) is a rare soft tissue tumour predominantly composed of mucinous and usually found around large joints. We report 73-year-old woman with 5-year history mass in the thenar eminence right wrist who presented to our department. An initial diagnosis ganglion cyst was made using magnetic resonance imaging (MRI) jellied content by aspiration. Two years after presentation, surgical treatment resection carpal tunnel release via radial approach performed because symptoms...

Patients with pediatric trigger thumb present fixed contracture of the interphalangeal joint (IPJ) or snapping thumb. We applied a hand-based dynamic splint using coils at IPJ. The aim this study was to report clinical outcomes therapy versus observation. One hundred twenty-nine thumbs (112 patients and 57 boys) were examined retrospectively. At initial presentation, parents selected treatment after explanation pathology consents obtained. Treatment concluded when full extension resolution...

Volar locking plate (VLP) fixation for distal radius fractures (DRF) is a technically demanding procedure, where accurate placement of the screws subchondral articular support essential. The purpose this retrospective, case-control study was to compare computed tomography (CT) navigation system VLP intra-articular DRF with conventional freehand fluoroscopy guided surgery. Twelve consecutive patients DRF, AO type C3.1, underwent using intraoperative CT (navigated group) and 16 had surgery...

The medial epicondyle nonunion becomes symptomatic valgus instability with elbow pain and joint due to dysfunction of the collateral ligament (MCL), thus requiring surgical treatment. purpose present study is report clinical result fragment excision reconstruction by free tendon graft in treatment nonunion.A retrospective five consecutive patients was performed. All had signs symptoms elbow. mean period 25 years, their injuries progressed asymptomatically until developed adulthood after a...

Intra-articular osteoid osteoma (OO) of the elbow is rare. We report a 26-year-old man who presented with pain, swelling, and limited range motion. Plain computed tomography (CT) showed radiolucent round lesion at distal humerus reactive bone in olecranon fossa. Conservative treatment salicylate failed under suspicion OO. During arthroscopy, red solitary was noted after resection white fossa excised en bloc using bony chisel. Histological examination The patient’s symptoms resolved day...

Background: Carpal tunnel syndrome is a compression neuropathy of the median nerve at wrist; its symptoms include neuropathic pain and sensory motor disturbance distributed by nerve. hypercholesterolemia have similar backgrounds, but effect these similarities on postoperative outcomes has not been reported. Using multivariate analysis, authors analyzed relationship between prognostic factors, including presence hypercholesterolemia, subjective patients with idiopathic carpal syndrome....

For open reduction and internal fixation of the displaced avulsion fractures base proximal phalanx fingers, volar A1 pulley approach was introduced instead dorsal approach. Although this procedure is quite useful, plate need to be divided. As a less invasive alternative, authors developed sparing technique treated six patients with median follow-up period 14 months. All healed without displacement, all regained full range motion any evidence instability. The minimally provides good...

We describe a patient with incomplete high median nerve palsy after surgical treatment of pediatric supracondylar humeral fracture (SCHF). Preoperative images 11 months the SCHF showed rotational deformity and an isolated entrapped between proximal humerus anteriorly callus posteriorly in bony tunnel distal humerus. Two years neurolysis, he clinical recovery. Four cases similar to our case were reported previously.Common fractures may cause unusual neuropathy. Rotational might be important...

The forearm connects the wrist and elbow joints, its stability depends on two articulations, proximal distal radioulnar interosseous membrane complex. aim of this case report is to present an acute longitudinal dissociation with humeral capitellum fracture.

Atraumatic subcutaneous rupture of the finger flexor tendon hand and forearm is rare. Most sites closed ruptures are tendon-bone insertion musculotendinous junction, an intratendinous lesion unusual. We report case a 76-year-old female who presented to our department with one-month history soft tissue mass limited flexion left middle without trauma. Preoperative magnetic resonance imaging revealed that caused flexion. Intraoperative findings showed digitorum profundus at phalanx; was...

Flexor tendon rupture in the wrist of patients with rheumatoid arthritis is a rare complication, and there no standard treatment for joint. Here, we present case flexor digitorum profundus left index finger owing to wrist. Plain radiography computed tomography showed carpal collapse, especially lunate, arthrosis between capitate lunate. For stability mobility finger, resection lunate radiotriquetral (RT) arthrodesis using distal ulna as bone graft interphalangeal joint were performed. At 2...