A5030520379- Fungal and yeast genetics research
- Cholinesterase and Neurodegenerative Diseases
- Platelet Disorders and Treatments
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Fungal Biology and Applications
- Helicobacter pylori-related gastroenterology studies
- Aluminum toxicity and tolerance in plants and animals
- Pancreatitis Pathology and Treatment
- Alzheimer's disease research and treatments
- Microbial Metabolic Engineering and Bioproduction
- Blood groups and transfusion
- Bioinformatics and Genomic Networks
- Erythrocyte Function and Pathophysiology
Universitat Pompeu Fabra
2017-2023
Banc de Sang i Teixits
2006
DRK-Blutspendedienst Baden-Württemberg - Hessen
2006
Abstract Upon environmental changes, proliferating cells delay cell cycle to prevent further damage accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function regulation of are still poorly understood. Here we report that expression co-regulated by cell-cycle-mediated factor Mcm1 stress-mediated factors Msn2/4. Overexpression arrests through inhibition Cdk1–G1 cyclin complexes at G1 stage stress-activated protein kinase-dependent T65, T69, T73 phosphorylation may...
BACKGROUND: The D category VI (DVI) is one of the clinically most important partial D. Three different molecular structures causing DVI phenotype have been described. STUDY DESIGN AND METHODS: To determine basis in Spanish population, 20 samples, previously detected serologic screening, were examined by polymerase chain reaction with RHD exon–specific primers. Unexpected findings further pursued cDNA nucleotide sequencing. RESULTS: A novel pattern exon amplification was detected, which did...
Yeast cells respond to hyperosmotic stress by activating the high‐osmolarity glycerol ( HOG ) pathway, which consists of two branches, Hkr1/Msb2‐Sho1 and Sln1, trigger phosphorylation nuclear internalization Hog1 mitogen‐activated protein kinase. In nucleus, regulates gene transcription cell cycle progression, allows adapt conditions. This study demonstrates that uncoupling known sensors both branches pathway at level Ssk1 Ste11 impairs growth in medium. However, under these conditions, was...
Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led treatments prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide screen Saccharomyces cerevisiae, using library of 5154 gene knock-out strains expressing Aβ1-42. We identified 81 mammalian orthologue genes that enhance Aβ1-42 while 157 were protective. Next, performed interactome and text-mining studies increase the number...