A5055144387- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Neuroscience and Neural Engineering
- Microfluidic and Capillary Electrophoresis Applications
- Conducting polymers and applications
- Microfluidic and Bio-sensing Technologies
- bioluminescence and chemiluminescence research
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- Advanced Chemical Sensor Technologies
- Bacterial biofilms and quorum sensing
- Electrical and Bioimpedance Tomography
- CRISPR and Genetic Engineering
- Advanced Biosensing Techniques and Applications
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cell Image Analysis Techniques
- Advanced Sensor and Energy Harvesting Materials
- Electrowetting and Microfluidic Technologies
- Gas Sensing Nanomaterials and Sensors
- Molecular Communication and Nanonetworks
- Plant and Biological Electrophysiology Studies
Ben-Gurion University of the Negev
2016-2024
University of Maryland, College Park
2012-2017
Sensors (United States)
2012-2017
Williams (United States)
2015
Integrated Sensors (United States)
2012-2014
Tel Aviv University
2008-2013
Individually, advances in microelectronics and biology transformed the way we live our lives. However, there remain few examples which electronics have been interfaced to create synergistic capabilities. We believe are two major challenges integration of biological components into microelectronic systems: (i) assembly at an electrode address, (ii) communication between assembled underlying electrode. Chitosan possesses a unique combination properties meet these serve as effective bio-device...
Graphical abstractAbstractWe demonstrate a low-cost standalone portable spectrophotometer for fast and reliable measurement execution. The data acquired can be both displayed via dedicated smartphone application or computer interface, allowing users either to gather view on the move set up continuous experiment. All design software files are open-source intended device easily replicable further customizable suit specific applications. assembled measure absorption in wavelength range from 450...
The use of electric fields in combination with small doses antibiotics for enhanced treatment biofilms is termed the 'bioelectric effect' (BE). Different mechanisms action AC and DC have been reported literature over last two decades. In this work, we conduct first study on correlation between electrical energy efficacy bioelectric effect Escherichia coli K-12 W3110 biofilms.A thorough was performed through application alternating (AC), direct (DC) superimposed (SP) potentials different...
Abstract Designing functional materials as electrode coatings to transduce high‐quality information about redox molecules in biofluids is crucial for developing the next‐generation medical devices. Rapidly analyzing neurotransmitter dopamine (DA) urinary levels can enable point‐of‐care testing neuroendocrine tumors. A novel sensing electrodes array modified with biopolymer chitosan and electrocatalytic carbon nanotube films that generate cross‐reactive electrochemical signals from complex...
Here, we integrated two key technologies within a microfluidic system, an electrokinetic preconcentration of analytes by ion Concentration Polarization (CP) and local electrochemical sensors to detect the analytes, which can synergistically act significantly enhance detection signal. This synergistic combination, offering both decoupled coupled operation modes for continuous monitoring, was validated intensified fluorescent intensities CP-preconcentrated associated enhanced response using...
Electrochemical sensors based on antibody-antigen recognition events are commonly used for the rapid, label-free, and sensitive detection of various analytes. However, parameters at bioelectronic interface, i.e., before after probe (such as an antibody) assembly onto electrode, have a dominant influence underlying performance analytes antigen). In this work, we thoroughly investigate dependence interface characteristics that not been investigated in depth: antibody density electrode's...
The field of in-vivo electrochemical sensors is envisioned to greatly transform point-of-care diagnostic devices and bio-chip sensing technology. However, these sensors' sensitivity selectivity suffer from fundamental challenges that deteriorate the output signal underlying information. In analytical chemistry, term 'chemometrics' involves utilizing advanced multivariate models signals; this shifts complexity analysis physical domain digital processing domain. These methods can help...
While clozapine (CLZ) is the most effective antipsychotic drug for schizophrenia treatment, it remains underused. In order to understand barriers of frequent blood draws white cell counts (WBCs) and levels, we developed a psychiatrist survey began an integrative approach designing point-of-care device that could eventually have real-time monitoring with immediate results.We ascertained related CLZ management acceptance possible solutions by sending anonymous physicians in psychiatric...
This work presents a thorough electrochemical and reliability analysis of sensing scheme for the antipsychotic clozapine. We have previously demonstrated novel detection approach this redox-active drug, highly effective in schizophrenia treatment, based on catechol-modified chitosan film. The biomaterial film enables amplification oxidative current generated by clozapine through redox cycling. Here, we study critical material aspects cycling system to overcome barriers point-of-care...
Microfluidics is a highly useful platform for culturing, monitoring, and testing biological cells. The integration of electrodes into microfluidic channels extends the functionality, sensing, capabilities systems. By employing an electrochemical impedance spectroscopy (EIS) technique, non-invasive, label-free detection activities cells in real-time can be achieved. To address movement toward spatially resolving cell culture, we developed sensory system capable electro-addressing location...
Antipsychotic clozapine is the most effective medication currently available for schizophrenia. However, dramatically underutilized due to its harsh side effects that are not effectively monitored. By continuously monitoring blood levels, such as use of an implantable glucometer, which has transformed diabetes management, treatment can be optimized and will minimized. Currently, none methods detection show ability repeatedly measure in whole without pretreatment steps. Here we propose using...
Within the gastrointestinal tract, mucosal layer, which is physical and homeostatic barrier between microbiome host, exhibits redox molecules such as mucin oxidative species generating oxygen gradient. These control structural state affect cross-communication in microbiome. Gut-on-Chip platforms are Organ-on-Chip devices that tend to imitate gut physiology; however, crucial epithelial-microbiome not well represented these platforms. The ability properly mimic gentle communication prokaryotic...
Three fabrication methods for metal-doped laser-induced graphene (LIG) are compared resulting in stable nanoparticles embedded within LIG. Variable nanoparticle size, distribution, antibacterial and electrochemical properties were observed.
Electronic communication in natural systems makes use, inter alia, of molecular transmission, where electron transfer occurs within networks redox reactions, which play a vital role many physiological systems. In view the limited understanding signaling, we developed an approach and electrochemical-optical lab-on-a-chip to observe cellular responses localized environments. The fluidic micro-system uses electrogenetic bacteria response is activated electrically chemically induced...