A5086362765- Microtubule and mitosis dynamics
- Influenza Virus Research Studies
- interferon and immune responses
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Treatment of Major Depression
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Stress Responses and Cortisol
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- 14-3-3 protein interactions
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Virus-based gene therapy research
- Protein Structure and Dynamics
- Nanoparticles: synthesis and applications
- Photosynthetic Processes and Mechanisms
- Extracellular vesicles in disease
University of Montana
2023-2024
University of Colorado Anschutz Medical Campus
2019-2024
The Ohio State University
2024
University of Colorado System
2018
University of Colorado Boulder
2018
Center for Neurosciences
2016
In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting several approved drugs multiple promising candidates clinical trials. Regulatory agencies such as the Food Drug Administration European Medicines Agency released important guidance documents facilitating nanoparticle-based drug product development, particularly context of liposomes lipid-based carriers. Even with achieved, it is clear that many barriers must still be overcome...
Recent interest in the antidepressant and anti-stress effects of subanesthetic doses ketamine, an NMDA receptor antagonist, has identified mechanisms whereby ketamine reverses effect stress, but little is known regarding prophylactic might have on future stressors. Here we investigate against neurochemical behavioral changes that follow inescapable, uncontrollable tail shocks (ISs) Sprague Dawley rats. IS induces increased anxiety, which dependent activation serotonergic (5-HT) dorsal raphe...
Abstract Stress is a potent etiological factor in the onset of major depressive disorder and posttraumatic stress (PTSD). Therefore, significant efforts have been made to identify factors that produce resilience outcomes later stressor, hopes preventing untoward clinical outcomes. The NMDA receptor antagonist ketamine has recently emerged as prophylactic capable neurochemical behavioral future stressor. Despite promising results preclinical studies performed male rats, effects proactive...
Tenofovir monoester is a relatively lipophilic intermediate formed during the hydrolysis of tenofovir disoproxil to tenofovir. Its clinical pharmacokinetic profile and influence on cellular pharmacology diphosphate have not been reported.Plasma, PBMC dried blood spots (DBS) were obtained from HIV-uninfected adults participating in randomized, cross-over bioequivalence study single-dose fumarate (TDF)/emtricitabine unencapsulated or encapsulated with Proteus® ingestible sensor. Plasma...
<title>Abstract</title> Immune reactions to nanomedicines can be detrimental the patient and compromise efficacy. However, our recent study characterizing effects of a type III interferon (IFN-λ) response lipid nanoparticles complexed with nucleic acids (lipoplexes) suggests that an IFN-λ pretreatment increase efficacy chemotherapeutic nanomedicines. In this we sought clarify which cell type(s) are capable producing in lipoplexes how propagated. Additionally, demonstrate is also altering...