A5080941345- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Bone Metabolism and Diseases
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Medical Imaging and Pathology Studies
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Bone fractures and treatments
- Cancer Cells and Metastasis
- Macrophage Migration Inhibitory Factor
- Prostate Cancer Treatment and Research
- Bone health and treatments
Science for Life Laboratory
2013-2018
Stockholm University
2016-2018
Uppsala University Hospital
2012-2016
Uppsala University
2011-2016
Liquid biopsies can be used in castration-resistant prostate cancer (CRPC) to detect androgen receptor splice variant 7 (AR-V7), a splicing product of the receptor. Patients with AR-V7-positive circulating tumor cells (CTCs) have greater benefit taxane chemotherapy compared novel hormonal therapies, indicating treatment-selection biomarker. Likewise, those pancreatic (PaCa),
MicroRNAs (miRNAs) are important post-transcriptional regulators that have recently introduced an additional level of intricacy to our understanding gene regulation. The aim this study was investigate miRNA–mRNA interactions may be relevant for bone metabolism by assessing correlations and interindividual variability in miRNA levels as well global between mRNA a large cohort primary human osteoblasts (HOBs) obtained during orthopedic surgery otherwise healthy individuals. We identified...
MicroRNAs (miRNAs) are a family of small, non-coding RNAs (17–24 nucleotides), which regulate gene expression either by the degradation target mRNAs or inhibiting translation genes. Recent studies have indicated that miRNA plays an important role in regulating osteoblast differentiation. In this study, we identified miR-203 and miR-320b as miRNAs modulating We Dlx5 potential common prediction algorithms confirmed knock-down over assessing at mRNA protein levels specificity was verified...
The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify sequence variants that able to account for disease association, we resequenced IFIH1. Eighty-six single-nucleotide (SNVs) potentially functional effect or differences in allele frequencies between patients controls determined by sequencing were further genotyped 1140 SLE 2060 controls. In addition, 108 imputed included association analysis. Ten SNVs three SLE....
Osteogenesis imperfecta, also known as "brittle bone disease", is a heterogeneous disorder of connective tissue generally caused by dominant mutations in the genes COL1A1 and COL1A2, encoding α1 α2 chains type I (pro)collagen.Symptomatic patients are usually prescribed bisphosphonates, but this treatment neither curative nor sufficient.A promising field gene silencing through RNA interference.In study small interfering RNAs (siRNAs) were designed to target each allele 3'UTR...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)