Objective: To examine adherence to adalimumab (ADA) and etanercept (ETA) health care costs in rheumatoid arthritis (RA) patients, explore the association between adherence, utilization costs.Research design methods: Using administrative claims data from a large managed plan, RA patients treated with or during period 01/01/2005 through 12/31/2005 were identified. The first dispensing date was defined as index date. Patient assessed 1 year post-index period.Main outcome measures: Nonadherence...

Treatment effectiveness depends upon administering medications as prescribed, and adherence is critical for Alzheimer's disease (AD) patients to receive optimal benefit from therapy. The objective of this study was investigate factors associated with AD oral medications.This retrospective claims analysis identified who initiated therapy (rivastigmine, donepezil, galantamine, or memantine) between January 1, 2006 December 31, 2007 a large US health plan. Patient baseline characteristics were...

AbstractObjective:This study explored physicians' perceptions of patient adherence to medications compared with derived by administrative data in the treatment osteoporosis.Research design and methods:A involving written questionnaires from prescribers treating patients postmenopausal osteoporosis (PMO) questionnaire responses pharmacy claims these prescribers' patients' refill patterns. Approximately 2000 physicians a large US health plan were faxed or mailed survey. Data physician survey...

To assess 12-month healthcare resource utilization and costs associated with upper gastrointestinal (UGI) bleeding events.Patients hospitalized a UGI event were identified in US national health-plan claims data (1999-2003) propensity matched to control patients without the same health plan. Matching criteria included age, gender, index date, Charlson Comorbidity Index score, geographic region, prior medical utilization.A total of 9,033 UGI-bleed 579,018 met inclusion criteria, yielding 4,651...

Abstract Background To study the prevalence of chronic kidney disease (CKD) and its impact on allopurinol dosing uric acid control among patients with gout. Methods This was a retrospective using data from large US health plan. Claims laboratory were analyzed for enrollees plan database January 2002 through December 2005. Patients gout identified pharmacy medical claims based presence codes medication or diagnosis. Severity CKD determined estimated glomerular filtration rate (eGFR)....

This study summarizes the literature on prevalence, incidence, and proportion of patients receiving treatment for male hypogonadism a systematic search was performed articles published in last 20 years. Of 97 studies identified, 96 examined 2 4 males with treatment. Based conducted Europe USA, prevalence general population ranged from 2.1% to 12.8% middle-aged older men, an estimated incidence 12 new cases per 1,000 person-years. Prevalence higher among comorbid conditions, such as type...

Objective:Medication adherence is an important component of effective secondary stroke prevention. The objectives this study were to examine the impact persistence with two prescription antiplatelet therapies on outcome recurrent hospitalized stroke, and identify predictors nonpersistence these therapies.Research design methods:Administrative claims from a large, geographically diverse US health plan used evaluate acetylsalicylic acid / extended-release dipyridamole (ASA/ERDP) treated...

The objective of this study was to measure the steady-state cerebrospinal fluid (CSF) concentration LY450108 and LY451395 (positive modulators AMPA receptors) in healthy subjects after administration 1 mg 5 mg. Secondary objectives included evaluation safety, pharmacokinetics, ratio plasma:CSF concentrations multiple dosing. This an open-label, oral dose evaluating 12 (3 per dosing group) subjects, aged 18 49 years. Twelve male completed study. were quantifiable CSF 1-mg 5-mg multiple-dose...

To evaluate real-world pharmacologic treatment of mixed dyslipidemia in patients with diabetes mellitus (DM). All commercial health plan members a large US managed care database complete lipid panel results (HDL-C, LDL-C, TG) between 1/1/2006 and 12/31/2006 were identified (N = 529,236). DM 53,679) defined as having any 2 suboptimal parameters 28,728). Lipid status 6 months pre- post-index date was determined using pharmacy claims for therapy. Post-index, 41.1% abnormal 45.1% 3 did not...

Patient flow between primary care physicians and gastroenterologists in the continuum of gastroesophageal reflux disease (GERD) is poorly understood. Using administrative claims data from a large US health plan linked with abstracted medical records, we examined: resource utilization for GERD subjects treated by (PCPs) (GEs), determinants subject transfer these physician types, reasons therapy change. Within sample 169,884 patients, 211,043 PCP-based episodes 40,304 GE-based were developed....

The objective of this study was to compare the pharmacokinetics insulin detemir in three ascending doses healthy Japanese and Caucasian subjects. This an open-label, single-center, parallel-group design evaluating 30 subjects (15 15 Caucasians). Subjects received a total subcutaneous injections (one injection per visit) (0.19, 0.38, 0.75 U/kg [1 U = 24 nmol]) order. Following drug administration, intravenous glucose 0.5-mg/kg/min increments every minutes, followed by constant rate 2.0...

Objective To report a case of delayed-onset dystonic reactions, oculogyric crisis (OGC), and torticollis after treatment with intramuscular haloperidol lactate injection. Case Summary A 22-year-old Mexican American woman received 7.5 mg followed 4 hours later by 10 mg. Twenty-six the first injection, patient reported that she was unable to lower her gaze neck stiff. She immediately given benztropine 2 mg; there nearly complete remission symptoms within 15 minutes treatment. An objective...