A5020024865- Genetic factors in colorectal cancer
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Colorectal Cancer Treatments and Studies
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Colorectal Cancer Screening and Detection
- Neuroscience of respiration and sleep
- Digital Imaging for Blood Diseases
- Advanced Proteomics Techniques and Applications
- Cell Image Analysis Techniques
- Bioinformatics and Genomic Networks
- Digital Imaging in Medicine
- Single-cell and spatial transcriptomics
- Olfactory and Sensory Function Studies
- Anatomy and Medical Technology
- Face Recognition and Perception
- Herbal Medicine Research Studies
- Neural dynamics and brain function
- Soil and Land Suitability Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Orthodontics and Dentofacial Orthopedics
- Biological and pharmacological studies of plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
Macquarie University
2013-2021
Rogers State University
2019
KU Leuven
2017-2018
Université de Montréal
2015
Université de Sherbrooke
2007-2008
American Association of Orthodontists
2004
Brooklyn College
1937
Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including periaqueductal gray and rostroventral medulla, also show selective activation when subjects expect relief. These brainstem regions send inhibitory projections spine produce diffuse analgesic responses. Regrettably precise contribution spinal mechanisms predicting strength analgesia is unknown. Here, we that...
The cannabinoid receptor type 1 (CB1 ) has an allosteric binding site. drugs ORG27569 {5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-1H-indole-2-carboxamide} and PSNCBAM-1 {1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea} have been extensively characterized with regard to their effects on signalling of the orthosteric ligand CP55,940 {(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol}, studies suggested that these modulators...
One of the most significant challenges in colorectal cancer (CRC) management is use compliant early stage population-based diagnostic tests as adjuncts to confirmatory colonoscopy. Despite near curative nature clinical surgical resection, mortality remains unacceptably high-as majority patients diagnosed by faecal haemoglobin followed colonoscopy occur at latter stages. Additionally, current screens reliant on fecal occult blood test (FOBT) have low compliance (~ 40%) and suffer...
Objective: In this study, we explored the analgesic and antihyperalgesic properties of a synthetic cannabinoid (nabilone) on experimental heat pain in men women, as well its effects descending inhibitory systems.Research design methods: A double-blind, placebo controlled, crossover study nabilone single doses 0.5 1 mg was conducted. Excitatory systems were elicited using temporal summation test (tonic evoked by Peltier thermode) administered before after activation control (triggered...
Background and purpose. Arachidonic acid (AA) its derivatives are important modulators of cellular signalling. The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a with functions in mediating responses to noxious stimuli inflammation. There limited information about the interactions between AA itself TRPA1, so we investigated effects key ethanolamide amino acid/neurotransmitter on hTRPA1.Experimental approach. HEK 293 cells expressing hTRPA1 were studied by...
N-arachidonyl dopamine (NADA) has been identified as a putative endocannabinoid, but there is little information about which signalling pathways it activates. The purpose of this study was to identify the activated by NADA in vitro.
MicroRNAs (miRNAs) are small non-protein coding RNAs and post-transcriptionally regulate cellular gene expression. In animal development, miRNAs play essential roles such as stem cell maintenance, organogenesis, apoptosis. Using gain-of-function (GOF) screening with 160 miRNA lines in Drosophila melanogaster, we identified a set of which regulates body fat contents named them microCATs (microRNAs Controlling Adipose Tissue). Further examination egg-to-adult developmental kinetics selected...
Nordihydroguaiaretic acid (NDGA) is a major biologically active component of the creosote bush, Larrea tridentate, widely used in unregulated therapies. NDGA lipoxygenase inhibitor while derivative, terameprocol, has been trialed as chemotherapeutic agent. When investigating fatty activation human transient receptor potential cation channel subfamily A, member 1 (hTRPA1), we found that activated channel. Here investigate actions and terameprocol at hTRPA1 consequences this for noxious cold...
A Correction to this paper has been published: https://doi.org/10.1038/s41593-020-00779-0.
Rodents' ability to segregate and recognize objects is still debated today. Our group showed that rats can distinguish figures on a background by focusing luminance-based first-order cues. In follow-up study, we demonstrated then learn differentiate between defined second-order texture-based The aim of this current study was design test novel discrimination task for mice whether they complex motion trajectories based upon 8 separated in two groups performed tasks automated touch screen...
Event Abstract Back to Assessment of second-order shape information in mice primary visual cortex. William J. Redmond1, 2* and Hans Op De Beeck2 1 Macquarie University, Australia 2 KU Leuven, Belgium The investigation high-level properties human cortical vision has long been modelled using mainly nonhuman primates. Yet, at least for transformation-invariant object recognition, rodents’ capabilities have now asserted as a valid tool study some characteristics recognition (1, 2). In this...