A5084985431- Peroxisome Proliferator-Activated Receptors
- Inflammasome and immune disorders
- Lipid Membrane Structure and Behavior
- Salmonella and Campylobacter epidemiology
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Biomarkers in Disease Mechanisms
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Ferroptosis and cancer prognosis
Central Drug Research Institute
1971-2024
Academy of Scientific and Innovative Research
2023-2024
<h2>Abstract</h2> Genome-wide association studies in inflammatory bowel disease have identified risk loci the <i>Orosomucoid like 3</i> (<i>ORMDL3</i>) gene to confer susceptibility ulcerative colitis (UC), but underlying functional relevance remains unexplored. Here, we found that a subpopulation of UC patients who had higher activity shows enhanced expression ORMDL3 compared with lower and non-UC controls. We also showing high <i>ORMDL3</i> mRNA elevated IL-1β cytokine levels indicating...
Altered mitochondrial function without a well-defined cause has been documented in patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we observed reduced expression of clustered homolog (CLUH) only the active tissues compared unaffected areas from same patient and healthy controls. Stimulation bacterial Toll-like receptor (TLR) ligands similarly CLUH human primary macrophages. Further, negatively regulated secretion proinflammatory cytokines IL-6 TNF-α...
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited function pro-bacterial organelle. The...
Tremorine has been widely used for the evaluation of antiparkinsonian drugs since its introduction by Everett (1). Jacobi (2) and Achari Sinha (3) found propranolol effective against tremorine-induced tremors in mice. Vas (4) Marsden Owen (5) reported beneficial effects Parkinsonian tremors. It was, therefore, decided to see if other β-adrenergic blocking agents also shared this activity. Some α-adrenergic were employed elucidate mechanism antagonism.
Abstract Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called -containing vacuoles (SCVs) avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how lysosomal can be transported SCV. We demonstrate here peroxisomes recruited SCVs human macrophages, epithelial cells functions as pro-bacterial organelles. Further, this interaction is assisted by SseI,...