A5052330576- SARS-CoV-2 and COVID-19 Research
- Head and Neck Cancer Studies
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Inflammasome and immune disorders
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Oral microbiology and periodontitis research
- Nitric Oxide and Endothelin Effects
- COVID-19 Clinical Research Studies
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Health and Contraception
- Hemoglobinopathies and Related Disorders
- Parathyroid Disorders and Treatments
- Lipid Membrane Structure and Behavior
- Liver Disease and Transplantation
- vaccines and immunoinformatics approaches
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 detection and testing
- Ethnobotanical and Medicinal Plants Studies
- Radiation Therapy and Dosimetry
- Infectious Encephalopathies and Encephalitis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
King George's Medical University
2021-2025
Central Drug Research Institute
2014-2025
Academy of Scientific and Innovative Research
2017-2024
Council of Scientific and Industrial Research
2017-2024
<h2>Abstract</h2> Genome-wide association studies in inflammatory bowel disease have identified risk loci the <i>Orosomucoid like 3</i> (<i>ORMDL3</i>) gene to confer susceptibility ulcerative colitis (UC), but underlying functional relevance remains unexplored. Here, we found that a subpopulation of UC patients who had higher activity shows enhanced expression ORMDL3 compared with lower and non-UC controls. We also showing high <i>ORMDL3</i> mRNA elevated IL-1β cytokine levels indicating...
Background and objective: Asymmetric dimethylarginine (ADMA) exacerbates endothelial dysfunction, which increases the risk of kidney cardiovascular problems. This study aimed to investigate association ADMA levels in patients with type 2 diabetes mellitus (T2DM), including diabetic heart disease (DKD). Materials methods: was a cross-sectional conducted tertiary hospital, 136 participants, categorizing them into four groups aged between 18-65 years: normal healthy controls (n=30), (DM) group...
A BSTRACT Objectives: To study the role of triglyceride glucose (TyG) index as a novel biomarker in patients with type 2 diabetes mellitus (T2DM) developing acute coronary syndrome (ACS). Methods: This was cross-sectional, case–control conducted over 1 year sample size 175 T2DM subjects divided into cases and controls at ratio 2:5 (50 cases: ACS, 125 controls: without ACS). The TyG calculated using formula Ln [fasting triglycerides (mg/dL) × fasting plasma (mg (dL)/2]. Result: In this study,...
Altered mitochondrial function without a well-defined cause has been documented in patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we observed reduced expression of clustered homolog (CLUH) only the active tissues compared unaffected areas from same patient and healthy controls. Stimulation bacterial Toll-like receptor (TLR) ligands similarly CLUH human primary macrophages. Further, negatively regulated secretion proinflammatory cytokines IL-6 TNF-α...
It is well established that obesity a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role regulation of adipokines. The objective the present study was to evaluate methylation status at promoter region leptin gene obese individuals its association with metabolic factors.The included (n=100) non-obese (n=75) aged 25-45 years, measured their physical, biochemical parameters (glucose, insulin, lipid profiles) leptin,...
To test efficacy, safety and tolerability of Umifenovir in non-severe COVID-19 adult patients.We carried out randomized, double-blind, placebo-controlled, multicenter, phase III trials involving (18-75 years), COVID19 patients, randomized 1:1 on placebo or (800 mg BID, maximum 14 days) respectively along with standard-of-care. The primary endpoint for Asymptotic-mild patients was time to nasopharyngeal swab RT-PCR negativity. For Moderate the average change ordinal scale from baseline scores...
IntroductionOral cancer accounts for approximately 2.1% of all cancers worldwide. In India, oral squamous cell carcinoma (OSCC) is the most common with half a million new cases diagnosed every year. More than 50% patients eventually develop local recurrence or metastasis usually within first 2-years following completion treatment. It beneficial to analyze prognostic significance Cyclin D1, p53 and EGFR which are critical mediators in pathogenesis OSCC. The objective this study was assess...
Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding vaccine effectiveness. Asymptomatic breakthrough infections have a major problem in assessing effectiveness populations globally. Serological discrimination infection so far limited Spike protein vaccines since whole virion generate antibodies against all proteins. Here, we show how statistical and machine learning (ML) based approach...
Anatomical variations in head and neck cancer during IMRT leads to volume shrinkage, results dosimetric tumour normal tissue including parotid glands, with a risk of radiation toxicities.30 patients stage II-IV squamous cell carcinoma (HNSCC) were treated definitive IMRT-SIB concomitant chemotherapy. Volumetric evaluated the period by recalculating obtaining dose-volume histograms re-contoured target volumes glands on repeat CT scans taken multiple times treatment (CT1, CT2, CT3 CT4).Result...
Background and objectives Microalbuminuria is an early sign of diabetic nephropathy (DN). However, pathological abnormalities occur before the onset microalbuminuria. Renal impairment progresses in about 50% cases type 2 diabetes mellitus (T2DM) without significant albuminuria. Diabetes (DM) linked with obesity, metabolic syndrome, lifestyle changes, where adipokines play important role. Zinc alpha glycoprotein (ZAGP) adipokine, this study, it was assessed as a potential biomarker for DN...
A high incidence of cardiovascular disease (CVD) events and premature mortality is observed in patients with chronic kidney (CKD). Thus, new biomarkers that may help predict the development CVD early stages CKD are being investigated along other traditional risk factors.To investigate cathepsin S as an biomarker for CKD.A total 64 were included classified into 2 groups: established non-established CVD. All submitted to routine investigations including complete blood count, random sugar,...
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited function pro-bacterial organelle. The...
Hypertension, "The silent killer" is a multifactorial disorder which asymptomatic and if left untreated leads to lethal complications. Nebivolol third generation beta blocker with additional vasodilating property due nitric oxide release.The current study aims assess efficacy safety of compare Atenolol.This was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into as per selection criteria. Patients randomized receive Atenolol 45 in each group...
The accelerated generation of endothelial microparticles (EMPs) and impaired angiogenesis are the markers vascular pathology during various cardiovascular inflammatory conditions including hypertension. Because studies comparing effects antihypertensive agents on these 2 parameters limited, this study was designed to compare 3 agents: aliskiren, nebivolol, olmesartan, EMP angiogenesis. Changes in hemodynamic serum count were determined after weeks drug treatments [aliskiren (30 mg/kg),...
Antimalarial drug combination therapy is now being widely used for the treatment of uncomplicated malaria. The objective present study was to investigate effects coadministration intramuscular α/β-arteether (α/β-AE) and oral sulfadoxine-pyrimethamine (SP) on pharmacokinetic properties each as a drug-drug interaction support development fixed-dose therapy. A single-dose, open-label, crossover clinical trial conducted in healthy adult Indian male volunteers (18 45 years, n = 13) who received...
Background and objectives Pulmonary hypertension (PH) is an independent risk factor for increased mortality, especially in patients undergoing hemodialysis (HD), but the mechanism of its development unknown. This study aimed at evaluating volume overload inflammation as potential variables to cause maintenance hemodialysis. Materials methods was observational cross-sectional conducted on a tertiary hospital northern India. Patients end-stage renal disease, aged 18 years or more, over two...
Hepcidin is being extensively studied for anemia and inflammation in chronic kidney disease (CKD) patients. thought to regulate iron metabolism by blockade through various mechanisms. Patients with CKD have early cardiac mortality due subclinical inflammation; hence, we hepcidin as a biomarker patients stage of relation inflammation. In our cross-sectional study, total 80 were enrolled whom, there 25, 26, 29 stages 1, 2, 3, respectively. divided into normal level (39), functional deficiency...
Objective: Dosimetric sparing of critical swallowing structures like constrictor muscles and larynx can lead to improved functional outcomes in head neck cancer patients treated by chemoradiation. Methods: A total 50 Patients with newly diagnosed, biopsy proven AJCC stage II–IV squamous cell cancers (HNSCC) were prospectively studied. 25 randomized each arm Dysphagia-optimized Intensity Modulated Radiotherapy (Do-IMRT) Standard (SIMRT) arm. Additional dose constraints applied the...
Consap is a locally acting, non-hormonal, herbal spermicidal contraceptive isolated from Sapindus mukorosii . It has been observed to be free systemic side-effects such as nausea, vomiting and irregularities in the menstrual cycle. woman-controlled reversible method which needs used before intercourse. additional antitrichomonas activity more vaginal-friendly. In present study, 521 women volunteers reproductive age group have screened at six centres. Of these, 470 were included trial...
Background and Aims:A febrile response is a common phenomenon in the ICU (Intensive Care Unit), often with complex unknown origins.Fever only one component of may or not be an indication severe infection. Subjects Methods:A caused by infection/s accompanied neutropenia where absolute neutrophil count goes below 500/mm 3 , predicted to go over next 48 hours.Febrile generally for infection requiring commencing empirical antibiotics after taking appropriate cultures.However, infections also...