A5028531139- Catalytic Alkyne Reactions
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Synthesis and Characterization of Pyrroles
- Catalysis and Hydrodesulfurization Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Phytochemical compounds biological activities
- Adipose Tissue and Metabolism
- Information Technology Governance and Strategy
- Ionic liquids properties and applications
- Regulation of Appetite and Obesity
- Sulfur-Based Synthesis Techniques
- Helicobacter pylori-related gastroenterology studies
- Landfill Environmental Impact Studies
- Grouting, Rheology, and Soil Mechanics
- Soil and Unsaturated Flow
Central Drug Research Institute
2020-2025
Academy of Scientific and Innovative Research
2020-2025
Medicina
2025
Ramakrishna Mission Vidyamandira
2022
Indian Institute of Engineering Science and Technology, Shibpur
2021
Centre National de la Recherche Scientifique
2016-2020
University of Lucknow
2020
Laboratoire d'Innovation Thérapeutique
2019-2020
Université de Strasbourg
2016-2020
University of Hyderabad
2010-2017
A general atom-economical approach for the synthesis of α-acyloxy methyl ketone is demonstrated through regioselective hydration a wide range propargyl acetates. Readily available catalyst comprising 1% Ph(3)PAuCl and AgSbF(6) in dioxane-H(2)O efficiently hydrolyzes terminal alkynes acetate absence acid promoters at ambient temperature within short time. Effective facilitated by neighboring carbonyl group as (18)O-labeling study. Compatibility functional moieties tolerance to various...
Hydrate your chemistry! Hydrative cyclization of 5-yne-ynamides in the presence Echavarren's catalyst and p-toluenesulphonic acid (PTSA)⋅H2O at room temperature affords an array 1,6-dihydropyridin-2(3H)one derivatives. Isomerization, epoxidation, hydrogenation double bond insertion extended π-conjugate system into pyridinone skeleton have been successfully accomplished (see scheme; Ts=tosyl). As a service to our authors readers, this journal provides supporting information supplied by...
Stable ynamides are used for the development of novel synthetic transformations and construction unusual carbo/heterocycles. The intramolecular cyclization π-tethered alkene/alkyne/allene-ynamides is studied extensively fabrication a wide range molecular scaffolds various applications. ketene-acetal/aminal generated in situ from participates cyclization/cycloisomerization processes to yield N-bearing fused heterocycles. This account summarizes scientific merits advances made...
A base promoted reaction between N-protected propargyl amines and 3-bromopropiolate readily provides an array of novel stable alkyne-tethered ketene N,N-acetals in good yields. wide range structurally complex cyclobutene-fused azepine heterocycles are synthesized through the gold-catalyzed intramolecular cycloisomerization for first time. plausible pathway is deduced on basis 1H NMR studies.
Pyrroles are frequently encountered in natural products, bioactive molecules and functional materials. Herein, a straightforward one pot zinc‐ copper‐catalyzed protocol, converting isoxazoles into pyrroles upon reaction with bis(ynamides) via skeletal editing has been developed. Notably, various substituted well tolerated, offering densely functionalized moderate to good yields.
Herein, we report for the first time a transition-metal-free and mild protocol that requires inexpensive K2CO3 silica gel direct access to polysubstituted indenes from readily obtainable starting precursors. Notably, sequential Michael addition, intramolecular cyclization, gel-promoted nucleophilic substitution reactions afford desired products. A broad range of indoles other aromatic nucleophiles are well-tolerated, affording in moderate good yields. Gratifyingly, indene could be easily...
The reaction of trimesic acid (H3TMA) with 2,6-bis(4-pyridylmethylene)cyclohexanone (1) in MeOH and phenol resulted a co-crystal H3TMA·1 (1 : 1). crystal structure this was found to contain triply interpenetrated (6,3) hydrogen bonded network. repeat without PhOH crystals an ionic compound which also contains both the components 1 ratio. solid exhibits doubly three-dimensional
A novel synthetic route to benzo[f]dihydroisoquinolone through a p-TsOH promoted cascade cyclization of easily accessible diyne-tethered ynamides in the presence Au(I)-catalyst is described. This reaction unveils broad substrate scope, constructing wide range benzo[f]dihydroisoquinolones good yields. The are synthesized from inexpensive o-iodoaniline Sonogashira couplings and Cu-mediated C-N bond formation. role examined, pathway also deduced. benzo[f]isoquinoline scaffold constructed...
Regioselective hydration of the terminal halo-substituted propargyl carboxylate by gold(I) catalyst is reported. The mild catalytic conditions tolerate common acid-labile protecting groups, and a wide variety α-acyloxy α′-halo ketones are efficiently synthesized within short reaction time. used for synthesis 2-aminothiazoles.
To test efficacy, safety and tolerability of Umifenovir in non-severe COVID-19 adult patients.We carried out randomized, double-blind, placebo-controlled, multicenter, phase III trials involving (18-75 years), COVID19 patients, randomized 1:1 on placebo or (800 mg BID, maximum 14 days) respectively along with standard-of-care. The primary endpoint for Asymptotic-mild patients was time to nasopharyngeal swab RT-PCR negativity. For Moderate the average change ordinal scale from baseline scores...
Scaffolds having a 1H-pyrrolo[3,2-c]pyridine core show significant biological activity. Herein, we report synergetic copper/zinc-catalyzed one-step annulation reaction of 2-amino (hetero)arylnitriles with ynamide-derived buta-1,3-diynes to deliver 1H-pyrrolo[3,2-c]quinoline-2,4-diamine derivatives in moderate good yields. The follows double cyclization pathway. gram-scale synthesis proves the practicality this protocol.
We report herein the synthesis of complex molecules containing furopyran cores through a gold(I)-catalyzed hetero-Diels–Alder cascade reaction. During this process, diene and dienophile are produced concomitantly by action single catalyst from starting material. Moreover, six bonds, four heterocycles, controlled stereogenic centers formed in one-step operation. DFT calculations provide mechanistic basis unprecedented
Abstract This manuscript reports on a suitable method for the synthesis of paracyclophane type, ferrocene‐bridged chiral phosphoric acids, which bear silyl‐substituents their frameworks. These acids have been obtained easily in enantiomerically pure form, by taking advantage ( S )‐(1‐phenyl‐2‐cyanoethyl)phosphorodiamidite as phosphorylating agent. They used then catalysts aza‐Friedel‐Crafts reactions between indoles and imines, giving high catalytic activity up to 98% enantiomeric excess....
Herein, a catalytic synthetic transformation offering series of -NH2 group-bearing aminoisoquinolines with moderate to good yields has been showcased. Interestingly, the nitrogen atom isoquinoline ring is coming from reaction medium upon metal-assisted C≡N bond cleavage. Moreover, this (5+1) annulation shows broad substrate variation. Furthermore, derivatization core via functional group interconversions and mechanistic studies identify intermediate have carried out successfully.
5,10-Dihydroindeno[1,2-
We report an efficient synthesis of furopyrans through a gold(I)-catalyzed domino reaction. By starting from the same source and changing solvent reaction, two classes are accessible. During this one-step process, which takes place in DMF, bonds heterocycles formed. DFT calculations furnish mechanistic understanding transformation. The sequence includes 5-endo-dig cyclization, regioselective 8-endo-dig retro 8π 6π electrocyclization.
A general strategy for the synthesis of 2,5-diamido-substituted N -arylpyrroles and structurally unique heterocycle-fused 1,3-diazepines using a Cu( ii ) catalyst has been showcased.
Silver-catalyzed cyclization and cycloisomerization of ketene N,N-acetals at room temperature has been developed to access a variety highly substituted cyclobutene-fused azepine 1,2-dihydropyridine derivatives. This cost-effective method is reliably implemented for the gram-scale synthesis dihydropyridine The iodo group in periphery motif can be functionalized with both Suzuki Sonogashira reactions.
A single-step protocol for the synthesis of 3,6-disubstituted 4-hydroxy 2<italic>H</italic>-pyrones under goldcatalyzed conditions is developed from alkynyl acids. The total pseudopyronine achieved with an overall 24% yield.
The syntheses of new scaffolds containing small strained rings are described via an original domino reaction. process works efficiently and selectively 4-<i>exo</i>-dig/5- or 6-<i>exo</i>-trig/3-<i>exo</i>-trig cyclocarbopalladations followed by a β-hydride elimination. During this cascade, the palladium moves several times along carbon structure for creation three C–C bonds rings.
Abstract Substituted pyrroles are prevalent aromatic ring systems encountered in numerous natural products and bioactive molecules. Herein, a novel ynamide scaffold has been designed, synthesized subsequently applied to an unprecedented gold‐catalyzed para ‐toluenesulfonic acid (PTSA)‐assisted cascade cycloisomerization reaction for the synthesis of β‐pyrrole substituted α,β‐unsaturated ketones. Notably, is stereoselective, offering E ‐isomer as major product with low moderate yield.
Cascade or domino reactions serve as a powerful technique for the synthesis of complex organic scaffolds in one pot. Herein, Cu(II)-catalyzed and silica gel-assisted multicomponent reaction (MCR) between bromoalkyne-tethered cyclohexadienones, amides, water construction hexahydrobenzofuran-3-carboxamide is developed. The proceeds via C–N coupling followed by hydrative cyclization ynamide intermediates. Notably, good to excellent diastereoselectivity complementary this reaction.
Herein, a one-pot desulfonylative protocol enabled by copper(II)/zinc(II) salts to access pyrrolo[2,3-b]quinolines in good excellent yields from 2-carbonylanilines and ynamide-derived buta-1,3-diynes has been reported. Significantly, various carrying reactive functional groups are well tolerated. Moreover, gram-scale synthesis synthetic application highlight the practical utility of current protocol. Notably, fluorescence properties have recorded, their potential use as fluorescent probe...