A5016585522- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Lipid Membrane Structure and Behavior
- vaccines and immunoinformatics approaches
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Natural Products and Biological Research
- Infectious Encephalopathies and Encephalitis
- Pharmacological Effects of Natural Compounds
- Salmonella and Campylobacter epidemiology
- Vaccine Coverage and Hesitancy
- Heme Oxygenase-1 and Carbon Monoxide
- Diet and metabolism studies
- Diverse Scientific Research Studies
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Influenza Virus Research Studies
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Ferroptosis and cancer prognosis
Central Drug Research Institute
2019-2024
Academy of Scientific and Innovative Research
2019-2024
Advanced Materials and Processes Research Institute
2022
Mahatma Gandhi Medical College and Research Institute
2020
Sri Balaji Vidyapeeth University
2020
<h2>Abstract</h2> Genome-wide association studies in inflammatory bowel disease have identified risk loci the <i>Orosomucoid like 3</i> (<i>ORMDL3</i>) gene to confer susceptibility ulcerative colitis (UC), but underlying functional relevance remains unexplored. Here, we found that a subpopulation of UC patients who had higher activity shows enhanced expression ORMDL3 compared with lower and non-UC controls. We also showing high <i>ORMDL3</i> mRNA elevated IL-1β cytokine levels indicating...
Altered mitochondrial function without a well-defined cause has been documented in patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we observed reduced expression of clustered homolog (CLUH) only the active tissues compared unaffected areas from same patient and healthy controls. Stimulation bacterial Toll-like receptor (TLR) ligands similarly CLUH human primary macrophages. Further, negatively regulated secretion proinflammatory cytokines IL-6 TNF-α...
Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding vaccine effectiveness. Asymptomatic breakthrough infections have a major problem in assessing effectiveness populations globally. Serological discrimination infection so far limited Spike protein vaccines since whole virion generate antibodies against all proteins. Here, we show how statistical and machine learning (ML) based approach...
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited function pro-bacterial organelle. The...
Antiviral resistance has emerged as a major global health challenge, undermining the efficacy of conventional antiviral drugs. This led researchers to explore alternative therapeutic agents, with flavonoids gaining attention due their potent properties. Derived from natural sources such fruits, vegetables, and herbs, have demonstrated broad-spectrum activities across various viral infections, including respiratory, gastrointestinal, exanthematous, hepatic, cutaneous, hemorrhagic,...
Abstract Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called -containing vacuoles (SCVs) avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how lysosomal can be transported SCV. We demonstrate here peroxisomes recruited SCVs human macrophages, epithelial cells functions as pro-bacterial organelles. Further, this interaction is assisted by SseI,...
Coronavirus are goes under an expansive group of infection that can cause respiratory sicknesses, for example, the normal chilly, as per Centres Disease Control and Prevention (CDC).They in various types creatures, including camels bats.Surprisingly, these crown infections develop taint people afterward spread between people.Ongoing instances this incorporate SARS-COV MERS-COV.2019 Novel Corona (2019-nCoV) is recognized reason a flare-up ailment initially identified Wuhan, China.This causes...
Abstract Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding effectiveness interventions. Asymptomatic breakthrough infections have a major problem during ongoing surge Delta variant globally. Serological discrimination vaccine infection so far limited Spike protein vaccines used in higher-income regions. Here, we show for first time how statistical and machine learning (ML) approaches...