Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher mechanism of action. We found miR-96/miR-182 downregulate Palladin protein levels, thereby reducing cell migration invasion. A common SNP, rs1071738, at miR-96/miR-182-binding site within 3'-UTR abolishes miRNA:mRNA binding, thus...

Significance The integration of biomaterials science, innovative imaging, and cancer biology now enables the design smart responsive material platforms for theranostics. We show herein that our developed nanovehicle is able to sense silence a multidrug resistance gene based on its expression in tumor microenvironment, followed by local chemotherapeutic drug release, with significant regression not achieved otherwise. This ON/OFF molecular nanoswitch approach can be used reverse many other...

Of all the much hyped and pricy cancer drugs, benefits from promising siRNA small molecule drugs are limited. Lack of efficient delivery vehicles that would release drug locally, protect it degradation, ensure high transfection efficiency, precludes fulfilling its full potential. This work presents a novel platform for local sustained with efficiencies both in vitro vivo breast mice model. protection efficiency enabled by their encapsulation oligopeptide‐terminated poly(β‐aminoester) (pBAE)...

A "one material fits all" mindset ignores profound differences in target tissues that affect their responses and reactivity. Yet little attention has been paid to the role of diseased tissue on performance, biocompatibility, healing capacity. We assessed material-tissue interactions with a prototypical adhesive based dendrimer/dextran colon as model platform. Adhesive materials have high sensitivity changes environment can be exploited probe quantify influence even subtle modifications...

Abstract Triple negative breast cancer patients remain with chemotherapy as their only viable therapeutic option. However, the toxicity of available anticancer drugs and inefficient delivery have limited development effective administration protocols combination therapies. Drug devices that can properly target to right cells efficient cancer‐cell killing may play a vital role in eliminating triple‐negative cancer. While systemic results low drug accumulation at tumor site for short period...

Abstract Biomaterial scaffolds that are designed to incorporate dynamic, spatiotemporal information have the potential interface with cells and tissues direct behavior. Here, a bioinspired, programmable nanotechnology‐based platform is described harnesses cellular traction forces activate growth factors, eliminating need for exogenous triggers (e.g., light), spatially diffuse enzymes, pH changes), or passive activation hydrolysis). Flexible aptamer technology used create modular, synthetic...

Machine Learning (ML) algorithms are ideal in silico tools to find patterns of cellular internalisation pBAE polyplexes various cell types, using chemical and biophysical material properties gene expression as model inputs.

We designed and optimized tissue-responsive adhesive materials by matching material tissue properties. A two-component based on dextran aldehyde dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking an interface created aldehyde-selective reaction with amines. By altering chemistry, we examined how variations in surfaces (serosal density the duodenum, jejunum, ileum) affect interactions of varied compositions (aldehyde content). Interestingly, same formulation reacts...

Impaired cutaneous healing leading to chronic wounds affects between 2 and 6% of the total population in most developed countries it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings mechanical debridement are often not effective, causing severe pain, emotional distress, social isolation patients for years or even decades, ultimately resulting limb amputation. Alternatively, gene therapy (such as mRNA therapies) has emerged viable option...

The complex and dynamic tissue microenvironment requires therapeutic biomaterials to be built from versatile building blocks that can meet variations in physiology are further altered local pathology, enhance the clinical outcomes. On page 1584 N. Artzi team show how advances material design characterization techniques now allow substantially more sophisticated tuning of biomaterial properties include exciting multi-functionalities including sensing, targeting, delivery. (Cover design: Joao Conde.)

In article number 1806380, Benjamin D. Almquist and co-workers describe a bioinspired nanotechnology platform that uses the cellular traction force as trigger for controlling release of growth factors. This method is straightforward to integrate with diverse biomaterial scaffolds, substrates, fabrication methods, enables novel capabilities like selective activation factors by different cell types.

In article number 1901101 by Natalie Artzi and co-workers, dual-sensitive nanogels rapidly dislodge the chemotherapy drug inside cancer cells through pH redox sensitivities, enabling efficient cancer-cell killing. Their incorporation into an injectable hydrogel, delivered to tumor-adjacent areas, enables prolonged release of nanogels, with instantaneous action once taken up cells, resulting in increased therapeutic efficacy.