A5047848414- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Diabetes and associated disorders
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Blood transfusion and management
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Hematopoietic Stem Cell Transplantation
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Neurology and Historical Studies
- Dialysis and Renal Disease Management
- Influenza Virus Research Studies
- Salivary Gland Disorders and Functions
- Retinal Diseases and Treatments
Royal Children's Hospital
1971-2021
Canberra Hospital
2019
The Royal Melbourne Hospital
1969-2016
Gold Coast Hospital
2008
The Alfred Hospital
2007
Royal Hospital for Children
2006
Queen Mary Hospital
2004
University of Hong Kong
2004
Palo Alto University
2000
Stanford University
2000
A group of 42 renal transplants performed in the presence a T-cell-positive crossmatch were analyzed to determine class and specificity donor-reactive cytotoxic antibodies. Dithiothreitol (DTT) was used reduce IgM antibodies monoclonal antibody directed at monomorphic determinant present on all HLA I antigens (PA2.6) inhibit cytotoxicity anti-HLA Sera from 26 positive crossmatches considered be autoreactive, proved due not each case. One year graft survival 100% 5 living-related 60% 21...
HLA types and blood glucose control were investigated in 127 insulin-dependent diabetics with different grades of severity retinopathy. The means all afternoon clinic levels from the diagnosis diabetes 9.9 ± 2.1 mmol/L for patients no retinopathy, 11.8 background 12.4 proliferative retinopathy (P < 0.0001). HLA-DR4 was present 61 87 (70%) or 21 39 (54%) frequency lowest despite “poor control” (mean ≥ 11.5 mmol/L) highest those who had developed “good control;” frequencies HLA-DR2...
Biopsies from 46 kidneys that were subsequently transplanted examined with monoclonal antibodies and the peroxidase-antiperoxidase technique to localize HLA-ABC OB antigens. There was no variation in expression of which present on all cells renal parenchyma. HLA-DR found consistently endothelium glomeruli in-tertubular capillaries but only weakly expressed, or not expressed at all, large vessels. The mesangium also stained for HLA-DR. But there a striking by proximal tubular kidneys. absent...
Abstract Spontaneous renal allograft rupture occurring within 14 days of transplantation occurred in 15 patients from 791 consecutive transplants. In each eight treated with azathioprine and prednisolone there was pathological evidence rejection only two had thrombosis the vein. Of seven cases triple therapy regimen (low dose cyclosporin, azathioprine), histological present three cases, but vein found all seven. a transplanted kidney, relatively uncommon complication, is more likely to be...
This article describes the production of red cell alloantibodies in 13 150 patients after bone marrow transplantation. New appeared 12 days to 11 months The specificities these antibodies were anti‐N, ‐Jka, ‐E‐like, ‐Kell‐ like, ‐M, ‐Leb, ‐Hl, ‐H and ‐A1. posttransplantation antibody could be due either transfusion mature lymphocytes along with marrow, ability grafted immune system produce alloantibodies, or viable immunocompetent cells remaining despite high‐dose chemotherapy irradation.
The distribution of HLA A, B, C, DR antigens was investigated in a British population with ulcerative colitis. Fifty six patients were typed for HLA, C and 46 additionally DR. No association found between the phenotype presence or absence Serum from 52 tested anticolon antibody. There no relation antibody phenotype. Finally, correlation phenotypes, age onset disease, extent clinical course.
S ummary . Thirty‐eight patients with severe aplastic anaemia or acute leukaemia received HLA‐identical sibling marrow transplants. Seventeen were treated methotrexate and 21 cyclosporin A (CyA) to minimize graft‐versus‐host disease post transplant. Marrow engraftment was more rapid oropharyngeal mucositis less in those receiving CyA. This resulted a shorter period of neutropenia thrombocytopenia, fewer platelet granulocyte transfusions fever. These benefits have be weighed against the...
Abstract One hundred consecutive first (n = 72) and regrafted 28) cadaver renal allograft recipients were immunosuppressed with cyclosporin, azathioprine prednisolone (triple therapy) followed for a median of 17.3 months (range, 7-26 months). Actuarial patient survival at 12 24 was 97.7 per cent. graft 79.5 cent (first 81.3 75 cent). HLA-DR matching significantly improved which 93 1 year in patients given compatible kidneys, compared 83 54 cent, respectively, who received kidneys mismatched...
In a study of 32 patients with bullous pemphigoid (BP), 16 cicatricial (CP) and 10 linear IgA disease (LAD) no significant association was found between these diseases HLA type the A, B, C DR loci. order to determine whether modified clinical expression subepidermal diseases, results were analysed for any mucosal involvement, presence scarring or occurrence circulating anti-basement membrane zone antibody. No associations found.
Salmonella mycotic thoracic aortic aneurysm is a rare but life-threatening condition. We report 59-year-old man with two aneurysms, presented fever and chills associated hoarseness due to left vocal cord palsy (Cardiovocal syndrome). Successful endovascular repair was performed using Talent stent-graft devices deployed separately cover the aneurysms. Subsequent computed tomography at 12 months after operation confirmed exclusion of pseudoaneurysms no endoleak. With potent antibiotics careful...
Abstract. Two cases of autoantibody formation following large volume plasmapheresis for rhesus immunisation during pregnancy are described. In each case the was directed against Rh complex but showed a preference G‐positive cells. It is postulated that repeated in presence persistent antigenic stimulation has removed feedback inhibition immune response. The specificity alloantibody broadened resulting cross‐reactivity self‐antigens. possible implications these relation to autoimmunity discussed.