A5103093041- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
University of Virginia
2016-2017
AraC Negative Regulators (ANR) suppress virulence genes by directly down-regulating AraC/XylS members in Gram-negative bacteria. In this study, we sought to investigate the distribution and molecular mechanisms of regulatory function for ANRs among different bacterial pathogens. We identified more than 200 distributed diverse clinically important gram negative pathogens, including Vibrio spp., Salmonella Shigella Yersinia Citrobacter enterotoxigenic (ETEC) enteroaggregative E. coli (EAEC),...
The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella Shigella Yersinia Citrobacter and pathogenic E. coli strains. We have previously reported broad effects the ANR members on AraC/XylS family. Here, we interrogate possible broader bacterial transcriptome. Our studies focused Aar (AggR-activated regulator), an archetype in enteroaggregative (EAEC) isolate...