A5051714061- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Animal Virus Infections Studies
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
- Cannabis and Cannabinoid Research
- Salmonella and Campylobacter epidemiology
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Clinical Nutrition and Gastroenterology
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Salivary Gland Disorders and Functions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Drug Transport and Resistance Mechanisms
- Bacterial Genetics and Biotechnology
University of Massachusetts Chan Medical School
2021-2023
Center for Research and Advanced Studies of the National Polytechnic Institute
2016-2022
Institute for Biomedicine
2019-2020
Instituto Politécnico Nacional
2016-2020
University of Virginia
2017
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting symptoms (long COVID). Long COVID is thought to be linked immune dysregulation due harmful inflammation, with exact causes being unknown. Given role of microbiome in mediating we aimed examine relationship between oral and duration long symptoms. Tongue swabs were collected from patients presenting Confirmed infections followed until resolution all Bacterial composition was...
Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect developing countries. Children who contract rarely screened to identify the etiologic agent due time cost considerations associated with pathogen-specific screening hence pathogen-directed therapy is uncommon. The development biomarkers rapidly underlying pathogens could improve treatment options clinical outcomes childhood diseases. Here, we perform RNA sequencing on blood samples...
Preventing aberrant inflammation is essential to maintaining homeostasis in the mammalian intestine. Although P-glycoprotein (P-gp) expression intestine critical for protecting intestinal epithelium from toxins and damage due neutrophil infiltration, its regulation poorly understood.
The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella Shigella Yersinia Citrobacter and pathogenic E. coli strains. We have previously reported broad effects the ANR members on AraC/XylS family. Here, we interrogate possible broader bacterial transcriptome. Our studies focused Aar (AggR-activated regulator), an archetype in enteroaggregative (EAEC) isolate...
Diarrheagenic E. coli can be separated into six distinct pathotypes, with enteroaggregative (EAEC) and diffusely-adherent (DAEC) among the least characterized. To gain additional insights these two pathotypes we performed whole genome sequencing of ten DAEC, nine EAEC strains, isolated from Mexican children diarrhea, one plus commensal strains an adult diarrhea a healthy child, respectively. These sequences were compared to 85 genomes available in public databases. The DAEC segregated...
Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of pathogenesis is this organism invades the colonic epithelia from basolateral pole. Therefore, it has evolved ability to disrupt intestinal epithelial barrier reach surface. We have shown previously secreted serine protease A (SepA), which belongs family autotransporters Enterobacteriaceae, responsible for initial destabilization facilitates invasion. However,...
Introduction. Cytolethal distending toxins (CDTs), encoded by cdt genes, have DNase activity leading to cellular and nuclear distension, resulting in irreversible cell cycle arrest apoptosis of target cells. cdt-positive Escherichia coli strains been isolated from children with diarrhoea. There is, however, scant information on the prevalence clinical presentation diarrhoeal disease caused these strains. Furthermore, toxin production is rarely confirmed. We report five young diarrhoea...
Typical enteroaggregative Escherichia coli (tEAEC) is a diarrheagenic E. pathotype associated with pediatric and traveler's diarrhea. Even without diarrhea, EAEC infections in children also lead to increased gut inflammation growth shortfalls. strain's defining phenotype the aggregative adherence pattern on epithelial cells attributable fimbriae (AAF). only causes diarrhea humans; therefore, not much known of exact intestinal region infection damage or its interactions enterocytes vivo situ....
Escherichia albertii is an emerging human enteropathogen. We report the draft genome sequence of E. strain Mex-12/320a, isolated from infant with diarrhea. The presence pathogenic island O122/IE6 and nleA gene, previously found in diarrheagenic enteropathogenic coli strains, suggests that may cause acute
Dysregulation of gut homeostasis may drive a variety pathological conditions like inflammatory bowel disease (IBD). One the first events associated with induction proinflammatory state is recruitment neutrophils to intestinal lumen. Neutrophils play critical role in maintenance by eliminating pathogens and contributing mucosal healing for resolution inflammation. However, an excessive accumulation activated intestine under conditions, such as IBD, injury. While basolateral release...
Los patotipos de Escherichia coli enterotoxigénica (ETEC) y enteroagregativa (EAEC) son importantes agentes etiológicos causantes diarrea en niños menores cinco años México países desarrollo, quienes causan numerosas muertes.Ambos se han asociado con retraso el crecimiento infantil los principales causales la "diarrea del viajero".La patogénesis ambas bacterias inicia cuando estas adhieren al epitelio intestinal mediante fimbrias, denominadas factores colonización las cepas ETEC aisladas...