A5017080068- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Quinazolinone synthesis and applications
- Biochemical and Molecular Research
- Diagnosis and treatment of tuberculosis
- Pharmacological Effects of Natural Compounds
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
- Global Maternal and Child Health
- RNA and protein synthesis mechanisms
Instituto Politécnico Nacional
2013-2024
Instituto Nacional de Perinatología
2019-2021
Ghent University
2016-2018
The perinatal consequences of SARS-CoV-2 infection are still largely unknown. This study aimed to describe the features and outcomes pregnant women with or without after universal screening was established in a large tertiary care center admitting only obstetric related conditions severe COVID-19 Mexico City. retrospective case-control integrates data between April 22 May 25, 2020, during active community transmission Mexico, one highest test positivity percentages worldwide. Only neonates...
Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could a potential agent treat nontuberculous mycobacterial (NTM) infection. The objective this study was evaluate vitro activity against rapidly growing mycobacteria by assessing minimal inhibitory concentration (MIC) and bactericidal (MBC) 18 NTM strains. For MIC determination we performed resazurin microtitre assay broth dilution, for MBC c.f.u. determined....
Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide. Lipids are abundant molecules during cycle of Mycobacterium tuberculosis (Mtb) and studies better mimicking its actual metabolic state pathogenesis needed. Though most have focused on mycobacterial lipid metabolism under standard culture conditions, little known about transcriptome Mtb in a environment. Here we determined H37Rv lipid-rich environment (cholesterol fatty acid) aerobic hypoxic using...
Abstract Background Nontuberculous mycobacteria (NTM) are environmental opportunistic pathogens found in natural and human-engineered waters, including drinking water distribution systems household plumbing. This pilot study examined the frequency of occurrence NTM potable samples Mexico City. Potable were collected from “main house faucet” kitchen faucet. The presence aerobic-mesophilic bacteria (AMB), total coliforms (TC), fecal (FC) species determined. Mycobacteria identified by PCR...
Bedaquiline (BDQ) is a recently approved antibiotic for the treatment of multidrug-resistant tuberculosis, but its potential against slow-growing mycobacteria (SGM) still unknown. The objective this study was to determine in vitro activity BDQ on SGM by assessing their MIC and minimal bactericidal concentration (MBC). 17 clinical isolates including Mycobacterium avium , intracellulare chimaera kansasii simiae species determined resazurin microtitre assay MBC c.f.u. determination 7H10 agar...
Although tuberculosis treatment is dependent on drug-susceptibility testing (DST) and molecular drug-resistance detection, failure relapse remain a challenge. This could be partially due to the emergence of antibiotic-tolerant dormant mycobacteria, where host lipids have been shown play an important role. study evaluated susceptibility Mycobacterium two antibiotic combinations – rifampicin, moxifloxacin, amikacin metronidazole (RIF-MXF-AMK-MTZ), pretomanid (RIF-MXF-AMK-PA) in lipid-rich...
The general features of the shift to a dormant state in mycobacterial species include several phenotypic changes, reduced metabolic activities, and increased resistance host environmental stress conditions. In this study, we aimed provide novel insights into viability morphological changes M. smegmatis that contribute its long-term survival under starvation or hypoxia. To end, conducted assays evaluate cell viability, gene expression. During starvation, exhibited reduction length, presence...
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