A5050905833- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Microplastics and Plastic Pollution
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Chemical Safety and Risk Management
- Pharmacogenetics and Drug Metabolism
- Pesticide and Herbicide Environmental Studies
- Drug-Induced Hepatotoxicity and Protection
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Environmental Chemistry and Analysis
- Antimicrobial agents and applications
- Recycling and Waste Management Techniques
- Chemistry and Chemical Engineering
- Alcohol Consumption and Health Effects
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Toxic Organic Pollutants Impact
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
- Cardiovascular and exercise physiology
University of Lausanne
2014-2024
Swiss Centre for Applied Human Toxicology
2023-2024
Centre universitaire de médecine générale et santé publique, Lausanne
2020-2024
Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat human health. Inhalation toxicological studies crucial for assessing the effects MPs and exposure-reduction measures. This communication paper addresses important health concerns related MPs, taking into consideration three levels complexity, i.e., themselves, additives present plastics, exogenous substances adsorbed...
Population studies reveal widespread exposure to phthalates. Understanding their absorption, distribution, metabolism, and excretion is vital reduce exposure. However, data on skin absorption remain limited. We thus aim characterize the permeation of three phthalates in a mixture, neat or emulsion; di(2-ethylhexyl) phthalate (d4-DEHP), dibutyl (d4-DBP), diethyl (d4-DEP), by comparing vitro human (800 µm) (24 hours) results using flow-through diffusion cells with urine obtained from...
Chemicals are not required to be tested systematically for their neurotoxic potency, although they may contribute the development of several neurological diseases. The absence systematic testing partially explained by current Organisation Economic Co-operation and Development (OECD) Test Guidelines, which rely on animal experiments that expensive, laborious, ethically debatable. Therefore, it is important understand risks exposed workers general population domestic products. In this study,...
The susceptibility profile of <italic>P. aeruginosa</italic> exposed to constant sub-inhibitory 3 concentrations quaternary ammonium compounds was characterized as well the 4 nanomechanical membrane properties.
Among pollutants released into the environment by human activities, residues of pharmaceuticals are an increasing matter concern because their potential impact on ecosystems. The aim this study was to analyze differences protein expression resulting from acute (2 days) and middle-term (7 exposure aquatic microcrustacean Daphnia pulex anticancer drug tamoxifen. Using a liquid chromatography-mass spectrometry shotgun approach, about 4000 proteins could be identified, providing largest...
Glycol ethers, such as propylene glycol monomethyl ether (PGME) and monobuthyl (PGBE) are solvents found in many professional domestic products. In biomonitoring studies, the type of materials used to collect, store, transport these samples can greatly influence analytical results because adsorb analyte. Plastic tubes generally have a hydrophobic internal surface that reduce concentration certain chemicals result an underestimation workers' exposures. The aim this study was assess whether...
Glycol ethers are organic solvents present in countless products for professional and domestic use. The main toxicological concerns hematotoxicity, respiratory reproductive toxicity. general population can be exposed when using containing one or several glycol that evaporate if sprayed, generate aerosols inhaled. rate at which enters blood following inhalation exposure unknown humans, chemical risk assessors only rely on animal vitro toxicity studies. Propylene monomethyl ether (PGME)...
Glycol ethers are solvents used in a plethora of occupational and household products exposing the users to potential toxic effects. Several glycol derived from ethylene induce hematological toxicity, such as anemia workers. The exposure effects on blood cells propylene unknown humans. aim our study was evaluate parameters indicative red cell (RBC) hemolysis oxidative stress participants exposed (propylene monobutyl ether (PGBE) monomethyl (PGME)), two extensively derivatives worldwide....
Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air aerosols and deposit on particulate matter during use by dispersion, evaporation, or abrasion. Phthalates are of growing concern due to their endocrine-disrupting effects. Human data absorption, distribution, metabolism, excretion (ADME) these upon inhalation almost nonexistent.The goal this study is develop a method for...
Introduction Daily exposition to ether glycols is common. Caretakers using cleaning products are critically exposed by combining physical activity with highly concentrated products. Previous animal studies showed hemato-, respiratory and autonomic nervous system toxicity amongst others. Yet, no controlled study explored the combination of an glycol ethers in humans. Methods 30 young healthy participants were a control condition (ambient air) one three vaporized ethers: propylene n-propyl...
Propylene glycol ethers (PGEs) are organic solvents commonly found as technical grade on the commercial market, mixtures of secondary (α-isomer) and primary (β-isomer, generally < 5%) alcohols. After handling products containing PGEs, they readily enter human body where metabolized. The minor β-isomer is oxidized by alcohol dehydrogenase (ADH) followed aldehyde (ALDH) to a potentially harmful metabolite. Although enzymatic rate needed estimate both parent metabolite internal exposures,...
<sec> <title>BACKGROUND</title> Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air aerosols and deposit on particulate matter during use by dispersion, evaporation, or abrasion. Phthalates are of growing concern due to their endocrine-disrupting effects. Human data absorption, distribution, metabolism, excretion (ADME) these upon inhalation almost nonexistent. </sec>...
<sec> <title>BACKGROUND</title> Chemicals are not required to be tested systematically for their neurotoxic potency, although they may contribute the development of several neurological diseases. The absence systematic testing partially explained by current Organisation Economic Co-operation and Development (OECD) Test Guidelines, which rely on animal experiments that expensive, laborious, ethically debatable. Therefore, it is important understand risks exposed workers general population...