A5012667942- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Radical Photochemical Reactions
- Electron Spin Resonance Studies
- Sulfur-Based Synthesis Techniques
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- RNA Interference and Gene Delivery
- Multicomponent Synthesis of Heterocycles
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Organoselenium and organotellurium chemistry
- Nanoparticle-Based Drug Delivery
- Metalloenzymes and iron-sulfur proteins
- Cancer therapeutics and mechanisms
- Hormonal Regulation and Hypertension
- Analytical Chemistry and Sensors
- Computational Drug Discovery Methods
- Redox biology and oxidative stress
- Advanced MRI Techniques and Applications
- Advanced Polymer Synthesis and Characterization
Latvijas Organiskās Sintēzes Institūts
2019-2025
Riga Stradiņš University
2019-2021
Abstract Mitochondria play critical roles in regulating cell fate, with dysfunction correlating the development of multiple diseases, emphasizing need for engineered nanomedicines that cross biological barriers. Said often target fluctuating mitochondrial properties and/or present inefficient/insufficient cytosolic delivery (resulting poor overall activity), while many require complex synthetic procedures involving targeting residues (hindering clinical translation). The...
Cardiolipin (CL) is a signature phospholipid of mitochondria that maintains the integrity mitochondrial membrane and supports proper function. Alterations in CL level composition can impair or, conversely, improve function bioenergetics, both which are critical for cancer metabolism. However, conflicting reports on levels across different types limited research using human patient samples limit our understanding its diagnostic potential. This cross-sectional study explores concentrations...
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number position were selected study their self-assembling properties, evaluation cytotoxicity vitro toxicity on microorganisms, characterisation interaction with phospholipids. These...
Proposing 3,5-dicyanopyridine motifs for the design of electroactive materials optoelectronic devices, three electron-transporting semiconductors are synthesised. The best performance was observed OLED containing FPDD as a host (EQE = 21.9%).
This study was designed to develop a fast and convenient methodology for the preparation of 10-nonyl acridine orange (NAO) its silyl analogues improve their photo-physical properties detection quantification cardiolipin (CL).
Abstract The development of targeted drugs for the treatment cancer remains an unmet medical need. This study was designed to investigate mechanism underlying breast cell growth suppression caused by fused isoselenazolium salts. ability suppress proliferation malignant and normal cells in vitro as well effect on NAD homeostasis (NAD + , NADH, NMN levels), NAMPT inhibition mitochondrial functionality were studied. interactions positively charged salts with negatively membrane model assessed....
Abstract A straightforward and atom‐economic method for the functionalization of short selenocystine‐containing peptides is presented. This shown to be tolerant unprotected peptides. The detailed protocol based on generation a selenium radical via visible light‐initiated reaction in presence transition metal‐free photocatalyst. further oxidized an electrophile trapped by N ‐heterocycles. mechanism confirmed NMR, HRMS, UV, EPR cyclic voltammetry (CV) experiments photocatalyst emission...
A mild and efficient method for preparation of 3-sulfenyl 3-selenyl coumarins quinolinones mediated by artificial light or sunlight is presented. The elaborated protocol highlights the use nonyl acridine orange as a photocatalyst to generate sulfenyl radical from thiols that further trapped heterocycle. utility justified diverse scope thiols, including short cysteine-containing peptides. same reaction conditions can be applied quinolinones. Various protected unprotected...
This study was focused on the estimation of targeted modification 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties (C12, C14 and C16); (2) N-substituent position 1 (N-H or N-CH3); (3) substituents pyridinium positions 2 6 (H, 4-CN 3-Ph); (4) substituent 4 (phenyl napthyl) physicochemical properties entire molecules characteristics obtained magnetoliposomes formed by them. It shown that thermal behavior tested amphiphiles related to chains length, elongation which...
The restoration of the efficacy antitumor medicines is a cornerstone in combat with multidrug resistant (MDR) cancers. overexpression ABCB1 transporter major obstacle to conventional doxorubicin therapy. synergy suppression and PARP1 activity inhibition that hampers malignant cell DNA repair could be powerful tool anticancer Herein, we report design synthesis three novel olaparib conjugates selenophenoquinolinones, their ability reverse resistance uterus sarcoma cells as well mechanism...
Abstract A visible light‐initiated method has been developed for preparation of Se−S bond‐containing peptides. The is based on generation sulfur‐centered radical employing organic dye. protocol tolerant to unprotected peptides with “sensitive” amino acids. stability bond evaluated in buffers at different pH (3.0–10.0) and also the presence oxidants reducing agents. Additionally, ability serve as an oxidation sensitive linker biocompatible materials confirmed. magnified image
The pyridine-3,5-dicarbonitrile moiety has gained significant attention in the field of materials chemistry, particularly development heavy-metal-free pure organic light-emitting diodes (OLEDs). Extensive research on compounds exhibiting thermally activated delayed fluorescence (TADF) led to numerous patents and articles. This study focuses synthesis investigation semiconducting properties polyaromatic π-systems containing two three fragments pyridine-2,6-dicarbazolyl-3,5-dicarbonitrile. are...
Selenophenoquinolinone is a prospective scaffold for the development of ABCB1 inhibitors treatment MDR cancers.
We report the design and synthesis of 7 novel benzoselenophenes, their ER-α binding activity cytotoxicity. Compound 21b is a considerably more effective binder (IC 50 = 0.44 nM) than widely known SERM drug raloxifene 1.78 nM).