A5091591750- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Pharmacological Effects of Natural Compounds
- Lignin and Wood Chemistry
- Lipid Membrane Structure and Behavior
- Dyeing and Modifying Textile Fibers
- Advanced Cellulose Research Studies
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Nanoparticle-Based Drug Delivery
Lund University
2020
University of Copenhagen
2013-2017
Cotton production is reaching a global limit, leading to growing demand for bio-based textile fibers produced by other means. Textile based on regenerated cellulose from wood holds great potential, but in order produce fibers, the components need be dissolved suitable solvents. Furthermore, dissolution process of not yet fully understood. In this study, we investigated state microcrystalline aqueous NaOH using primarily scattering methods. Contrary previous findings, study indicated that...
Identification of new vaccine adjuvants with immunopotentiating properties commonly involves in vitro evaluations candidate compounds for their ability to stimulate cells the immune system. Subsequent elaborate experiments are then performed on only positive candidates. Here we show how this strategy may miss good candidates due context-dependent supramolecular characteristics compounds, since both a specific molecular structure and correct presentation parts required successful stimulation...
Proteolytically stable α-peptide/β-peptoid peptidomimetics constitute promising cell-penetrating carrier candidates exhibiting superior cellular uptake as compared to commonly used peptides (CPPs). The aim of the present study was explore potential these for delivery small interfering RNA (siRNA) cytosol by incorporation a palmitoylated peptidomimetic construct into cationic lipid-based nanocarrier system. optimal selected on basis effect palmitoylation and influence length interaction with...
The mycobacterial cell-wall lipid monomycoloyl glycerol (MMG) is a potent immunostimulator, and cationic liposomes composed of shorter synthetic analogue (MMG-1) dimethyldioctadecylammonium (DDA) bromide represent promising adjuvant that induces strong antigen-specific Th1 Th17 responses. In the present study, we investigated supramolecular structure in vivo activity dispersions based on binary mixtures DDA an array MMG-1 analogues (MMG-2/3/5/6) displaying longer (MMG-2) or (MMG-3) alkyl...
Synthetic mycobacterial cord factor analogues, e.g., trehalose 6,6'-dibehenate (TDB), are highly promising adjuvants due to their strong immunopotentiating capabilities, but biophysical properties have remained poorly characterized. Here, we report the synthesis of an array synthetic TDB analogues varying in acyl chain length, degree acylation, and headgroup display, which was subjected characterization neat nondispersed self-assembled nanostructures excess buffer as aqueous dispersions with...
Synthetic analogues of the cell-wall lipid monomycoloyl glycerol (MMG) are promising as next-generation vaccine adjuvants. In present study, thermotropic phase behavior an array synthetic MMG was examined by using simultaneous small- and wide-angle X-ray scattering under excess water conditions. The differed in alkyl chain lengths stereochemistry polar headgroup or tails (native-like versus alternative compounds). All formed poorly hydrated lamellar phases at low temperatures inverse...