A5036108474- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Food Chemistry and Fat Analysis
- Nanoparticle-Based Drug Delivery
- Proteins in Food Systems
- Advancements in Transdermal Drug Delivery
- Liquid Crystal Research Advancements
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Microfluidic and Capillary Electrophoresis Applications
- Antimicrobial Peptides and Activities
- Fatty Acid Research and Health
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Pickering emulsions and particle stabilization
- Spectroscopy and Quantum Chemical Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lipid metabolism and biosynthesis
- Protein Interaction Studies and Fluorescence Analysis
- Complement system in diseases
- Block Copolymer Self-Assembly
- Bacterial biofilms and quorum sensing
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
University of Copenhagen
2016-2025
Oslo University Hospital
2019
De Montfort University
2019
Newcastle University
2019
University of Colorado Anschutz Medical Campus
2019
Kobe Pharmaceutical University
2014
University of Graz
2004-2012
Austrian Academy of Sciences
2007-2009
Nestlé (Switzerland)
2001-2006
University of Lausanne
2006
Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance antimicrobial agents immune system. Thus, viable options eradicate embedded on medical implants are surgical operations long-term repeated antibiotic courses. Recent years have witnessed growing interest in development robust reliable strategies for prevention treatment IAIs. In particular, it seems promising develop materials with...
Self-assembled nanostructures, such as inverted type mesophases of the cubic or hexagonal geometry reverse microemulsion phases, can be dispersed using a polymeric stabilizer, PEO-PPO-PEO triblock copolymer Pluronic F127. The particles, which are described in present study, based on monolinolein (MLO)-water mixtures. When adding tetradecane (TC) to MLO-water-F127 system at constant temperature, internal nanostructure kinetically stabilized particles transforms from Pn3m (cubosomes) H2...
Aqueous submicron-sized dispersions of the binary monolinolein/water system, which are stabilized by means a polymer, internally possess distinct nanostructure. Taking this as our starting point, we were able to demonstrate for first time that internal structure dispersed particles can be tuned temperature in reversible way. Upon increasing temperature, undergoes transition from cubic via hexagonal fluid isotropic, so-called L2 phase, and vice versa. Intriguingly, addition structural changes...
Microemulsions based on five-component mixtures for food applications and improved oil solubilization have been studied. The compositions included water, phase [such as R(+)-limonene medium-chain triglycerides (MCT)], short-chain alcohols (such ethanol), polyols (propylene glycol glycerol), several surfactants their corresponding (nonionic, such ethoxylated sorbitan esters, polyglycerol sugar ester, anionic, phosphatidylcholine). behavior of these systems is discussed with respect to the...
In our recent work, we reported on the effect of varying temperature and solubilizing tetradecane (TC) structural transitions observed in dispersed particles based monolinolein (MLO)-water-TC system. At a given temperature, addition TC induces transition internal structure from bicontinuous cubic phase, Pn3m, to reversed hexagonal, H2, isotropic liquid phase (water-in-oil (W/O) microemulsions). Our present study focuses discovery Fd3m (reversed discontinuous micellar cubic), which is formed...
Water-dilutable food-grade microemulsions consisting of ethoxylated sorbitan esters, and in some cases blended with other emulsifiers, water, (R)-(+)-limonene, ethanol, propylene glycol, have been prepared. These are growing interest to the food industry as vehicles for delivering enhancing solubilization natural supplements nutritional health benefits. Lycopene, an active lipophilic antioxidant from tomato, has solubilized water-in-oil, bicontinuous, oil-in-water types up 10 times oil...
Summary Low molecular weight surfactants, for example monoglycerides and phospholipids, form a multitude of self‐assembled structures, such as inverted cubic or hexagonal mesophases, if brought into contact with water/oil. These mesophases can be dispersed in water using adequate surface‐active materials low surfactants surface active polymers. In order to use mesophase particles incorporating drugs aromas, it is essential determine their internal crystallographic structure understand...
This work describes the effect of two different surfactants on internal nanostructure kinetically stabilized isasomes (internally self-assembled particles or "somes"), which are a new family colloidal (cubosomes, hexosomes, micellar cubosomes, and emulsified microemulsions, EME). The stabilization these systems is performed by using polymeric stabilizer F127. We demonstrate that structure oil-free oil-loaded dispersed can be modulated varying lipid composition. To achieve this goal, we...
This study reports the effect of loading four different charged designer lipid-like short anionic and cationic peptide surfactants on fully hydrated monoolein (MO)-based Pn3m phase (Q(224)). The studied comprise seven amino acid residues, namely A(6)D, DA(6), A(6)K, KA(6). D (aspartic acid) bears two negative charges, K (lysine) one positive charge, A (alanine) constitutes hydrophobic tail. To elucidate impact these surfactants, ternary MO/peptide/water system has been investigated using...
This report details the structural characterization and in vitro drug-release properties of different local anesthetic bupivacaine (BUP)-loaded inverted-type liquid crystalline phases microemulsions. The effects variations lipid composition and/or BUP concentration on self-assembled nanostructures were investigated presence commercial distilled glycerol monooleate Myverol 18–99K (GMO) medium-chain triglycerides (MCT). Synchrotron small-angle X-ray scattering (SAXS) rotating dialysis cell...
Stimuli-responsive nanocarriers based on lipid self-assemblies have the potential to provide targeted delivery of antimicrobial peptides, limiting their side effects while protecting them from degradation in biological environments. In present study, we design and characterize a simple pH-responsive nanomaterial, formed through self-assembly oleic acid (OA) with human cathelicidin LL-37 as model for an amphiphilic peptide. Colloidal transformations core–shell cylindrical micelles...